Charlotte Fare

Organization of core mitochondrial replication components into multiphasic condensates www.biorxiv.org/content/10.6...

Computationally Designed RNA Aptamers Enable Selective Detection of FUS Pathology in ALS www.researchsquare.com/article/rs-8...

Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine - Nature Chemical Biology Mast cells are immune cells that release membraneless mast cell extracellular granules (MCEGs) in response to allergic inflammation and pathogen infection. MCEGs are found to be condensates formed thr...

Mast cell extracellular granules are found to be condensates formed through sugar-metabolite interactions with elevated pH and higher metal concentration that enrich and enhance the activity of immune modulators, such as cytokines and proteases

www.nature.com/articles/s41...

Nuclear speckles enable processing of RNA from GC-rich isochores Nuclear speckles are key subnuclear structures that regulate gene expression in GC-rich regions. This work shows that the evolution and expansion of core speckle proteins were crucial for the increase...

The function of nuclear speckles is revealed! This is an incredibly important paper with absolutely beautiful data! Wow! www.cell.com/cell/fulltex...

Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease - Nature Mapping of neurogenesis in human hippocampi across ages and different cognitive abilities using multiomic single-cell sequencing reveals distinct signatures between cognitive preservation and decline.

Nature research paper: Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease

go.nature.com/4uat5v4

An Antibody–Oligonucleotide Conjugate for Myotonic Dystrophy Type 1 | NEJM Myotonic dystrophy type 1 is a rare, dominantly inherited, progressive, disabling, neuromuscular disease that leads to decreased life expectancy and has no approved therapies. The disease is caused...

An Antibody–Oligonucleotide Conjugate for Myotonic Dystrophy Type 1 www.nejm.org/doi/abs/10.1...

Organyl 5′‑Phosphates in siRNA Guide Strands: Structure–Function Relationships Governing Anchoring in Argonaute 2 and Metabolic Stability www.biorxiv.org/content/10.6...

High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging www.biorxiv.org/content/10.6...

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/...

C9orf72 hexanucleotide repeat RNA drives transcriptional dysregulation through genome-wide DNA:RNA hybrid G-quadruplexes Liu et al. demonstrate that expanded C9orf72 G4C2 repeat RNAs bind gene promoters across the genome and form HQ structures with DNA. These structures obstruct key transcription machinery, repress gene...

C9orf72 hexanucleotide repeat RNA drives transcriptional dysregulation through genome-wide DNA:RNA hybrid G-quadruplexes www.cell.com/neuron/fullt...

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease INTRODUCTION The PSEN1E280A mutation causes autosomal dominant Alzheimer's disease (ADAD) with predictable onset, enabling presymptomatic studies. Extracellular vesicles (EVs) are emerging biomarker...

Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Frontiers | ATP-Sensitive Peptide-Based Coacervates for Intracellular Delivery of Therapeutic Oligonucleotides Despite advances in the fields of lipoplexes, metal nanoparticles, and other nucleic acid carriers, intracellular delivery of DNA/RNA therapeutics remains a ...

ATP-Sensitive Peptide-Based Coacervates for Intracellular Delivery of Therapeutic Oligonucleotides www.frontiersin.org/journals/mol...

Immune cells from the gut drive development of Parkinson’s disease in the brain In ‘body-first’ Parkinson’s disease, misfolded proteins propagate from the gut’s nervous system to the brain. Immune-cell activity seems to play a key part in this spread.

Parkinson’s disease has the fastest-growing prevalence of any neurodegenerative disorder worldwide

go.nature.com/4r0xZsk

Design, validation and functional impact of oligonucleotides for multigene silencing in Alzheimer’s Disease This work establishes multigene RNA silencing as a viable therapeutic approach for Alzheimer’s disease. Bispecific antisense oligonucleotides produced strong, selective knockdown across multiple patho...

Design, validation and functional impact of oligonucleotides for multigene silencing in Alzheimer’s Disease www.cell.com/molecular-th...

Pathological TDP-43 filaments accumulate at synapses and cause synaptic dysfunction www.biorxiv.org/content/10.6...

Dynamic conformational ensembles of soluble Tau encode neuronal toxicity prior to aggregation https://www.biorxiv.org/content/10.64898/2026.01.26.701882v1

Is SORL1 a common genetic target across neurodegenerative diseases?: A multi-ancestry biobank scale assessment SORL1, the gene encoding the SORLA protein, has arisen as a potential therapeutic target for Alzheimer′s disease (AD). Studies suggest that restoring SORLA function or its trafficking pathways, partic...

Is SORL1 a common genetic target across neurodegenerative diseases?: A multi-ancestry biobank scale assessment www.medrxiv.org/content/10.6...

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases - Nature Immunology Nature Immunology - Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases www.nature.com/articles/s41...

Molecular features of human pathological tau distinguish tauopathy-associated dementias The FLEXITau platform provides detailed, quantitative, peptide-resolved molecular maps of tau for six tauopathies, as well as symptomatic and asymptomatic controls. The data identify disease-specific ...

Molecular features of human pathological tau distinguish tauopathy-associated dementias www.cell.com/cell/fulltex...

The sequence context of RG/RGG motifs determines condensate formation, transportin-1 binding and chaperoning www.biorxiv.org/content/10.6...

Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology Neuronal cytoplasmic aggregation and nuclear depletion of the TAR DNA-binding protein 43 (TDP-43) is the most characteristic pathology of amyotrophic …

Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology

www.sciencedirect.com/science/arti...

Flexible use of a multi-purpose tool by a cow Osuna-Mascaró and Auersperg report flexible, multipurpose tool use in a cow, expanding the known range of mammalian tool users and underscoring overlooked cognitive capacities in livestock.

Flexible use of a multi-purpose tool by a cow: Current Biology www.cell.com/current-biol...

The role of the nuclear pore complex in the stability of disease-related short tandem DNA repeats https://www.biorxiv.org/content/10.64898/2026.01.15.699629v1

The Structured RNA-binding Domains and Condensation Capacity of FUS Shape its RNA-binding Landscape and Function. https://www.biorxiv.org/content/10.64898/2026.01.12.699057v1

VAPB Confers Selective Neuroprotection by Driving Autophagic Degradation of Pathogenic Aggregates in ALS www.researchsquare.com/article/rs-8...

📣 New preprint 📣

Excited to share our latest work, which I helped lead, identifying a new class of TDP-43 dependent cryptic gene-TE spliced transcripts (crypTEs) in induced neurons and ALS patients.

🔍 Actively searching for postdoc & industry research roles.

doi.org/10.64898/2026.01.09.698641

Acute neuronal inhibition response caused by phosphorothioate antisense oligonucleotides following local delivery to the central nervous system Abstract. Antisense oligonucleotides (ASOs) are an important therapeutic modality for neurological diseases. Some ASOs cause transient neurobehavioral resp

Acute neuronal inhibition response caused by phosphorothioate antisense oligonucleotides following local delivery to the central nervous system academic.oup.com/nar/article/...

Prion-like MAVS fibrils stitch mitochondria to promote a rapid antiviral response - Cellular & Molecular Immunology Cellular & Molecular Immunology - Prion-like MAVS fibrils stitch mitochondria to promote a rapid antiviral response

How do cells trigger an antiviral response so quickly? 🤔 Our new paper proposes an "Intermitochondrial Activation" model. By visualizing MAVS with Cryo-ET, we saw that activated mitochondria use MAVS fibrils to "fish" for dormant mitochondria, spreading the alarm signal fast. doi.org/10.1038/s414...

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains Guo et al. elucidate short RNA chaperones that prevent and reverse toxic cytoplasmic aggregation of the prion-like, ALS/FTD-linked proteins FUS and TDP-43. By restoring the nuclear localization of FUS...

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains www.cell.com/molecular-ce...

TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia Recent work has shown that TDP-43 loss in frontotemporal dementia (FTD) induces changes in alternative polyadenylation, but the functional consequences of this are unclear. This study reports that 3′U...

TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia dx.plos.org/10.1371/jour...