Structural basis for domain coupling in heteromeric glycine receptors revealed by an atypical allosteric agonist Counteracting ligands stabilize glycine receptor states revealing mechanisms of pentameric ligand-gated channel allostery.

Check out our latest paper on the glycine receptor with
@chakrapanilab.bsky.social

where we show the interplay between the orthosteric and allosteric binding sites.

www.science.org/doi/10.1126/...

Sudha (@chakrapanilab.bsky.social) and Julio (@cvlab.bsky.social) are organizing the 2026 Ion Channel Gordon Research Conference: Ion Channels Across Scales — Bridging Molecular Events to Physiological Outcomes, to be held at Mount Holyoke College, July 12–17, 2026.

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Fabulous science at #BPS2025!
I owe a BIG debt of gratitude to @cyclocrossguy.bsky.social and to @chakrapanilab.bsky.social!

One more time,
Thank you Sudha and Chris for an inspiring, energising, and productive #BPS2025!
I am already looking forward to #BPS2026 in SF.
@biophysicalsoc.bsky.social @chakrapanilab.bsky.social @cyclocrossguy.bsky.social

Wonderful New and Notable Symposium this morning @biophysicalsoc.bsky.social #BPS2025 - wonderful talks from @ibudin.bsky.social , Jia Zhou #UCSD, @lmkdassama.bsky.social , Anne Houdusse - shout out to my co-chair this am @chakrapanilab.bsky.social

Gabriela, THANK YOU for your leadership of the BPS!!! It was an honor to co-chair the program with Chris! @biophysicalsoc.bsky.social @popstarlab.bsky.social.

2025 BPS Program Chairs Highlight Exciting Offerings YouTube video by WebsEdge Science

Joining us to highlight some of the exciting offerings at the #bps2025 Annual Meeting in LA are 2025 Program Committee Co-Chairs Dr. Chrisopher Yip & Dr Sudha Chakrapani! @biophysicalsoc.bsky.social @uoftengdean.bsky.social @cyclocrossguy.bsky.social @chakrapanilab.bsky.social youtu.be/iXBQOEOfGDA

Almost a wrap here @biophysicalsoc.bsky.social #BPS2025 - thank you @popstarlab.bsky.social for your leadership and support, and Sudha Chakrapani for being an amazing co-chair. What a ton of fun and yes I am indeed “inspired and tired”😃

Thanks, Cornelius! Excited to be here.

Mechanisms underlying modulation of human GlyRα3 receptors by Zn2+ and pH - PubMed Glycine receptors (GlyRs) regulate motor control and pain processing in the central nervous system through inhibitory synaptic signaling. The subtype GlyRα3 expressed in nociceptive sensory neurons of...

A real pleasure to be part of this work with
@chakrapanilab.bsky.social where we looked at zinc and pH modulation in glycine receptors. Some critical insight into the underling mechanism - pubmed.ncbi.nlm.nih.gov/39693447/