#SingleCell preprints

A novel subset of hepatocytes is simultaneously gluconeogenic and de novo lipogenic in the fed state and is naturally insulin resistant #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.09.710526v1

A context dependent hierarchy of APOBEC3A and APOBEC3B mutators in lung adenocarcinoma #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.09.710641v1

Myeloid HIF-1α Sustains Hypoxic Fibrotic Fronts and Drives Pulmonary Fibrosis #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.09.710578v1

Shared and organ-specific gene expression programs of fibrotic diseases #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.09.709232v1

scDEcrypter: Uncertainty-aware differential expression analysis for viral infection in scRNA-seq #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.09.710583v1

Cross-Species Transfer Learning for Electrophysiology-to-Transcriptomics Mapping in Cortical GABAergic Interneurons #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2603.11000

Theory of Cell Body Lensing and Phototaxis Sign Reversal in "Eyeless" Mutants of $Chlamydomonas$ #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2603.10986

Discovery of a Hematopoietic Manifold in scGPT Yields a Method for Extracting Performant Algorithms from Biological Foundation Model Internals #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2603.10261

Single-cell directional sensing at ultra-low chemoattractant concentrations from extreme first-passage events #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2603.10207

MESSI: Multimodal Experiments with SyStematic Interrogation using nextflow #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.09.710452v1

Cell DiffErential Expression by Pooling (CellDEEP) highlights issues in differential gene expression in scRNA-seq #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.09.710522v1

Reprogramming of neuronal genome function and phenotype by astrocytes #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.07.710282v1

Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.09.710505v1

Decoupling Lineage and Intrinsic Information in Single-Cell Lineage Tracing Data with Deep Disentangled Representation Learning #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.10.710716v1

LACC1 attenuates LPS-induced acute lung injury by inhibiting inflammatory response in alveolar macrophage through LPAR3/PI3K/AKT/mTOR signaling pathway #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8929971/latest

Lamotrigine Modulates Peripheral dual positive Th2/Th17 cells in Bipolar Disorder: A Role Beyond the Brain #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8917613/latest

Diagnostic and Prognostic Significance of Fallopian Tube Ciliated Epithelial Cell Markers in Serous Ovarian Cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8695930/latest

Mechanistic deconvolution of tuberculosis treatment failure using multiomic and causal network approaches #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8820174/latest

Decoding melanoma-immune cell communication through spatially resolved ligand-receptor interaction analyses #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-9075388/latest

Construction of a Diagnostic Model for Nasopharyngeal Carcinoma Using a Consensus Machine Learning Approach and Study of Immune Infiltration Characteristics #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8765619/latest

Role of myeloid cells and leukotriene signalling in Uveal Melanoma progression #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8735458/latest

Immune dysregulation caused by novel gain-of-function UNC93B1 variant with enhanced antigen presentation #SingleCell 🧪🧬🖥️
https://www.medrxiv.org/content/10.64898/2026.03.03.26347379v1

NOX4 contributes to the initiation and progression of AAA in a cell type-specific manner #SingleCell 🧪🧬🖥️
https://www.medrxiv.org/content/10.64898/2026.03.04.26347161v1

Inferring large networks with matrix factorisation to capture non-linear dependencies among genes using sparse single-cell profiles #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.08.710347v1

Scn4b Modulates Huntington's Disease Phenotype Severity in vivo #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.03.08.708251v1

The mechanism of atorvastatin-induced sarcopenia elucidated based on network toxicology, single-cell RNA sequencing, and bulk transcriptomics data #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-9058922/latest

Characterizing Nonlinear Dynamics via Smooth Prototype Equivalences #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2503.10336

Retrieval-Augmented Generation for Predicting Cellular Responses to Gene Perturbation #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2603.07233

HarmonyCell: Automating Single-Cell Perturbation Modeling under Semantic and Distribution Shifts #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2603.01396

Partial domain adaptation enables cross domain cell type annotation between scRNA-seq and snRNA-seq #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2511.08996