MetaStem

Metabolic costs and trade-offs of hypermetabolism in human motor neurons with ATP synthase deficiency - Communications Biology Hypermetabolism results in the redistribution of acetyl-CoA usage, reduced histone acetylation, and potential vulnerabilities of motor neurons via altered maintenance of acetylcholine

News from our CoE by @htyynismaa.bsky.social and Ruben Torregrosa Munumer labs. Mitochondrial ATP synthase deficiency results in Metabolic trade-offs and vulnerabilities in stem cell derived motor neurons www.nature.com/articles/s42... @helsinki.fi @stemmprogram.bsky.social

Next MetaStem PhD defense in two days, go Hien! 🎩

Still time today to sign up and submit an abstract for this excellent symposium

Next MetaStem PhD defense coming up on Tuesday, go Simon 👏@simonsterson.bsky.social

Tomorrow, welcome!

Stem Cell Metabolism, MetaStem Symposium Nov 12th 2025 | Centre of Excellence in Stem Cell Metabolism | University of Helsinki The symposium is organized by the Centre of Excellence in Stem Cell Metabolism, MetaStem on November 12th 2025 in Biomedicum Helsinki. The symposium is open and free of charge. Registration and poster...

Check out our website for more info and updates www.helsinki.fi/en/researchg...

Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social

Welcome to the Stem Cell Seminar next week Friday Oct 3rd at 9-11, ☕️🍪 at 8:30. Exciting science on embryo development, ECM, cancer and stem cells by Juha Kere and @johannaienglund.bsky.social labs. See you there! @hilife-helsinki.bsky.social @helsinki-biotech.bsky.social @stemmprogram.bsky.social

#CFM_MolCellAging: The third session will deal with the regulation of aging processes, with talks by
@pekka-katajisto.bsky.social  @metastem.bsky.social  @helsinki.fi and Salvador Aznar @irbbarcelona.org

  Registration: http://bit.ly/4kOyYch  

🤝With support of @caixaresearch.bsky.social

Welcome to the Metabolism seminar tomorrow in Viikki. Excited to have @nunuping.bsky.social and @sirakarvinen.bsky.social groups present their research

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

News from our CoE by @katajistolab.bsky.social @simonsterson.bsky.social found that intestinal stem cells with old mitochondria make Paneth cells faster due to higher aKG levels and aKG improves regeneration in old animals by renewal of Paneth cells. www.nature.com/articles/s42... @helsinki.fi

Stem-cell-derived beta cells mature metabolically upon murine engraftment - Diabetologia Aims/hypothesis The use of stem-cell-derived islets (SC-islets) as a source for cell-based therapy of type 1 diabetes shows great potential. However, SC-islets have a metabolically immature phenotype ...

News from our CoE by @otonkoskit.bsky.social lab, Eliisa Vähäkangas et al show that upon engraftment into mice stem cell derived pancreatic islets become insensitive to pyruvate, correlating with down regulation of the pyruvate/lactate transporter MCT1. link.springer.com/article/10.1... @helsinki.fi

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

Dose-dependent CHCHD10 dysregulation dictates motor neuron disease severity and alters creatine metabolism - Acta Neuropathologica Communications Dominant defects in CHCHD10, a mitochondrial intermembrane space protein, lead to a range of neurological and muscle disease phenotypes including amyotrophic lateral sclerosis. Many patients present w...

News from our CoE by @htyynismaa.bsky.social group characterize the role of mitochondrial intermembrane space protein CHCHD10 in metabolism and spinal muscular atrophy Jokela type (SMAJ) actaneurocomms.biomedcentral.com/articles/10.... Congratulations Sandra! @helsinki.fi @stemmprogram.bsky.social

Hien’s peroxisome story is out! Amazing effort starting from description of a new phenomenon, building in vivo tools, and describing how sub-cellular localization of metabolic activities can guide stem cell fate. Congrats Hien and thank you to the great collaborators!

Last Friday Pooja Manjunath successfully defended her thesis on Mitochondrial proteostasis and structure. Well done Dr Pooja 🎩👏 @htyynismaa.bsky.social @stemmprogram.bsky.social

Organelle age guides tissue renewal through subcellular compartmentalization of metabolism | Faculty of Biological and Environmental Sciences | University of Helsinki A new study sheds light on the mechanisms that regulate how our tissues develop and are constantly renewed to keep up their function. In the future, these results might contribute to the understanding...

A new study from our CoE finds that stem cells can control whether they self-renew or differentiate by localizing certain metabolic reactions differently www.helsinki.fi/en/faculty-b... @helsinki.fi @helsinki-biotech.bsky.social #stemcell #metabolism #peroxisome

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

News for our CoE by @katajistolab.bsky.social show how tissue stem cells can metabolically regulate tissue renewal and differentiation by providing daughter cells with peroxisomes of different age and metabolic properties nature.com/articles/s41... @helsinki.fi @helsinki-biotech.bsky.social

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9

Glad to be highlighted as FutureLeaders in Cancer research by Cancer Grand Challenges @cancergrand.bsky.social. Thank you! @fimm-uh.bsky.social, @helsinki-biotech.bsky.social, @metastem.bsky.social, @cruk-si.bsky.social.

features.cancerresearchuk.org/cancergrandc...

Tomorrow, welcome!

MetaStem PhD defence 🎩 April 25th at 12 Pooja Manjunath from @htyynismaa.bsky.social lab will defend her thesis Preserving Mitochondrial Proteostasis and Structure-The Roles of Mitochondrial Co-Chaperones GRPEL1, GRPEL2, and Small Protein NERCLIN in Porthania PIII. Opponent Prof Kostas Tokatlidis 👏

Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social

Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social

The @katajistolab.bsky.social modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a mediator of fetal-like reprogramming.

Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn
Listen to the conversation: bit.ly/4kTt36a

Tomorrow, welcome! 👇

Welcome to the next Metabolism seminar, March 18th at 9-11 am in Meilahti. Excellent speaker lineup with Kirsi Pietiläinen and Robin Cristofari groups presenting about #obesity #adiposetissue #diet #aging in humans and penguins @helsinki.fi @stemmprogram.bsky.social @helsinki-biotech.bsky.social

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

News from our CoE by @katajistolab.bsky.social @sharifiqbal.bsky.social shed light on how the intestinal epithelium is repaired after injury, with implications for aging and chemotherapy-induced damage www.sciencedirect.com/science/arti... @helsinki.fi @helsinki-biotech.bsky.social Congratulations 🎉

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

Congratulations Dr Hossam Montaser! 🎩 Great discussion with Professor Evans-Molina yesterday @stemmprogram.bsky.social @otonkoskit.bsky.social