ISI - ICMUB's department of chemistry for health

The DNA damaging properties of the experimental G-quadruplex (G4) drug QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC https://www.biorxiv.org/content/10.64898/2026.02.06.704351v1

The molecular helicase PhpC developed by ISI's researchers to unfold G-quadruplex #G4 DNA and RNA is now commercially available at Idylle @idylle-labs.bsky.social
👉 shorturl.at/efE5l
Its ability to unfold G4s in human cells was just thoroughly described in this preprint
👉 doi.org/10.64898/202...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: HV-OCTAMamba: A high-order vision Mamba network for robust retinal vasculature segmentation in OCTA images
@elsevierconnect.bsky.social
100% ICMUB! @cnrs.fr
👉 doi.org/10.1016/j.bs...

Hybrid Operative Room for Vascular Neurosurgery: Applications, Limits, and Perspectives Hybrid operating rooms (HORs) combine a conventional state-of-the-art microsurgical theater and advanced imaging technologies, usually an intraoperative digital subtraction angiography (DSA) system. I...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Hybrid Operative Room for Vascular Neurosurgery: Applications, Limits, and Perspectives
In Advances and Technical Standards in Neurosurgery @springernature.com
@cnrs.fr
👉 link.springer.com/chapter/10.1...

Embolization of the middle meningeal artery for chronic subdural hematoma: The OTEMACS multicenter, randomized, clinical trial protocol - Sam Ng, Imad Derraz, Gaultier Marnat, Vincent Jecko, Jean Papa... Background The role of middle meningeal artery (MMA) embolization as an adjunct to standard treatment in chronic subdural hematoma (CSDH) is debated. Further ra...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Embolization of the middle meningeal artery for chronic subdural hematoma: The OTEMACS multicenter, randomized, clinical trial protocol
In Interv. Neuroradiol. @journals.sagepub.com
@cnrs.fr @inserm.fr
w/ @umontpellier.bsky.social
👉 doi.org/10.1177/1591...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Feasibility and safety of electrocorticography monitoring after acute brain injury to detect cortical spreading depolarisation, a prospective observational study in a neurological intensive care unit
In Anaesth Crit Care Pain Med
w/ @bihatcharite.bsky.social
👉 doi.org/10.1016/j.ac...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Postnatally overfed mice display cardiac function alteration following myocardial infarction
In Biochim. Biophys. Acta (BBA) @elsevierconnect.bsky.social l
@cnrs.fr @inserm.fr
👉 doi.org/10.1016/j.bb...

In-depth understanding of the multimodal deformable image registration tool of a 0.35 T MR-linac Linear accelerators (linac) with embedded magnetic resonance (MR) imaging involves a specific workflow that includes systematically a deformable image registration (DIR) with computed tomography image...

𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: In-depth understanding of the multimodal deformable image registration tool of a 0.35 T MR-linac
In Medical Dosimetry @elsevierconnect.bsky.social
@cnrs.fr @inserm.fr
👉 www.meddos.org/article/S095...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: CD40 Agonist on Patient-Derived Xenograft Mice for the Treatment of B-Cell Acute Lymphoblastic Leukemia
In Clin. Cancer Res.
@cnrs.fr @inserm.fr
👉 doi.org/10.1158/1078...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Alignment Between Treatment Decision and Treatment Administration for Squamous Cell Carcinoma of the Upper Aerodigestive Tract Before, During, and After the COVID-19 Pandemic: A Retrospective Analysis
In J. Clin. Med. @mdpiopenaccess.bsky.social
👉 doi.org/10.3390/jcm1...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Recurrence of Head and Neck Squamous Cell Carcinoma: Did the COVID-19 Pandemic Have an Impact on Therapeutic Management?
In the Journal of Clinical Medicine @mdpiopenaccess.bsky.social
👉 doi.org/10.3390/jcm1...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Audiometric results of tympanoplasty with stapedectomy and synthetic total ossicular replacement prosthesis: A STROBE analysis
In @sciencedirect.bsky.social
👉 doi.org/10.1016/j.an...

Is 2D-augmented reality precise enough for middle ear endoscopic surgery? - European Archives of Oto-Rhino-Laryngology Augmented reality in the operating room enhances surgical precision. Merging information from preoperative 3D imaging into the real-time video during surgery allows for better visualization of critica...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Is 2D-augmented reality precise enough for middle ear endoscopic surgery?
In @springernature.com
👉 doi.org/10.1007/s004...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Deciphering the intermolecular interactions between G-quadruplex (G4)-forming sequences
In @narjournal.bsky.social
With Nanjing Univ. and @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1093/nar/...

@ICMUB attended the G4 Days in Paris, organized by members of @polytechniqueparis.bsky.social and it was fantastic!

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Convergent Synthesis of Template-Assembled Synthetic G-Quartets (TASQs) Used as Biomimetic and Multivalent G-Quadruplex (G4) Ligands
100% ICMUB!
@cnrs.fr
👉 doi.org/10.1002/chem...

Deep learning-driven false-lumen volumes predict adverse remodeling better than diameter in patients with residual aortic dissection on CT - European Radiology Objectives 1. To develop a deep-learning segmentation model for automated measurement of maximal aortic diameter (Dmax) and volumes of aortic dissection components: true-lumen (TL), circulating false-...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Deep learning-driven false-lumen volumes predict adverse remodeling better than diameter in patients with residual aortic dissection on CT
With the CRMBM & @aphm-chu-marseille.bsky.social , Marseille, FR
@cnrs.fr
👉 doi.org/10.1007/s003...

Convolutional Autoencoder Effect on Parallel Magnetic Resonance Imaging Parallel magnetic resonance imaging (pMRI) reduces MRI acquisition time, with Sensitivity Encoding (SENSE) being a widely used method that exploits coil sensitivity maps for efficient image reconstru...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Convolutional Autoencoder Effect on Parallel Magnetic Resonance Imaging
With the Laboratory of Biomedical Engineering, Tlemcen DZ
@cnrs.fr
dx.doi.org/10.1002/ima....

Designing an ecofriendly catalyst for a sustainable use of water resources Abstract. The printing and dyeing industry is one of the most polluting (ca. 20% of global clean water pollution), water-consuming and energy-wasting secto

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Designing an ecofriendly catalyst for a sustainable use of water resources
In @oxfordacademic.bsky.social
With Nanjing Univ. and @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1093/nsr/...

Photoactivatable, Biomimetic Ligand photoMultiTASQ Traps DNA/RNA G-Quadruplexes and Their Protein Binding Partners The biological role of DNA and RNA G-quadruplexes (G4s) is relayed to the cellular circuitry by a plethora of proteins known as G4-binding proteins (G4PBs). It is thus critical to decipher the formation of the G4/G4BP complexes to accurately understand their involvement in G4-mediated regulatory mechanisms. While hundreds of G4-interacting compounds (G4 ligands) have been used to uncover G4 biology in a rather indirect manner, only a handful of multivalent ligands allowing for identifying associated proteins have been designed, mostly relying on the covalent capture of G4BPs upon photoactivation. We report herein on such a multivalent ligand named photoMultiTASQ, which belongs to a family of biomimetic and smart G4 ligands known as template-assembled synthetic G-quartets (TASQs). We show how photoMultiTASQ interacts with and photo-cross-links both DNA/RNA G4s and related G4BPs, and develop a new mass spectrometry (MS)-based technique to characterize the covalent adducts. Collectively, these results make photoMultiTASQ a new molecular tool in the arsenal of chemical cross-linking and isolation by pull-down (Chem-CLIP) technologies that uniquely identify targets and validate target engagement in cells.

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Photoactivatable, Biomimetic Ligand photoMultiTASQ Traps DNA/RNA G-Quadruplexes and Their Protein Binding Partners
In @pubs.acs.org
With Weizmann Institute of Science (WIS) and @iphc-strasbourg.bsky.social
@cnrs.fr
doi.org/10.1021/acsb...

A Chimeric Photo-Controllable CRISPR/Cas12a System for Universal and Fast Diagnostics The potential of clustered regularly interspaced short palindromic repeats (CRISPR) and corresponding CRISPR-associated (Cas) protein systems (CRISPR/Cas) systems for biomedical applications is tremendous; however, precise control of their activity is essential to better harness this potential and, beyond this, to develop reliable diagnostic reagents. Herein, we report on such a strategy by controlling the CRISPR/Cas12a activity using a photo-controllable CRISPR RNA (crRNA). To this end, the 3′ end of crRNA was conjugated to a G-quadruplex (G4) block through a photocleavable linker: upon photo irradiation, the G4 trigger is removed, thus allowing for the DNA target to access and hybridize with the crRNA, and thus be processed by the CRISPR/Cas12a system. The efficiency of this approach was demonstrated by the detection of human papillomavirus 16 DNA in 50 clinical samples: our one-pot strategy was found to be as efficient as the routinely implemented method (qPCR), with 95.7% sensitivity and 100% specificity, in addition to be faster (25 versus 60 min) and both simpler and less expensive (being implementable as lateral flow test strips). Collectively, this new and fully controllable CRISPR/Cas system holds great potential for next-generation clinical diagnostics.

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: A Chimeric Photo-Controllable CRISPR/Cas12a System for Universal and Fast Diagnostics
In @pubs.acs.org
With Nanjing Univ. and @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1021/acs....

Versatile Bifunctional PYTA Derivatives for 225Ac Radiolabeling: A Comparison to Gold Standards We report the synthesis and evaluation of the first 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane-3,6,10,13-tetraacetic acid (PYTA) bifunctional chelators (BFCs) for 225Ac coordination. Me...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲:Versatile Bifunctional PYTA Derivatives for 225Ac Radiolabeling: A Comparison to Gold Standards
In @journalofnucmed.bsky.social
doi.org/10.2967/jnum...
With www.chematech-mdt.com
@cnrs.fr

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Dense Calcification of the Common Femoral Artery Is Protective Against In-Stent Restenosis
In J. Clin. Med. @mdpiopenaccess.bsky.social
With @ap-hp.bsky.social
doi.org/10.3390/jcm1...
@cnrs.fr

Supramolecular Chemistry Enables Radiolabeling of Proteins under Mild Conditions Monoclonal antibodies have proven to be highly effective for in vivo targeting in nuclear medicine applications. However, typical radiolabeling methods, for PET/SPECT imaging and targeted radionuclide...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Supramolecular Chemistry Enables Radiolabeling of Proteins under Mild Conditions
In Molecular Pharmaceuticals @acs.org
With @radboudumc.bsky.social
@cnrs.fr
doi.org/10.1021/acs....

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Selecting the Right AI Algorithm for the Job: A Guide for Navigating the AI Jungle in Ophthalmology
With CHU Dijon (FR)
@cnrs.fr
👉 tvst.arvojournals.org/article.aspx...

One-year outcomes of glue prostate-artery-embolization for symptomatic benign prostatic hyperplasia: a single-center retrospective cohort study - European Radiology Objectives To assess 12-month outcomes of prostate artery embolization (PAE) using N-butyl cyanoacrylate (NBCA) glue in patients with incapacitating lower-urinary-tract symptoms (LUTS) due to benign p...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: One-year outcomes of glue prostate-artery-embolization for symptomatic benign prostatic hyperplasia: a single-center retrospective cohort study
With CHU Dijon (FR)
@cnrs.fr
👉 doi.org/10.1007/s003...

A Selective and Sensitive Method for Colistin Detection by G-Quadruplex Ligand Competition Colistin (COL) is a widely used antibiotic and is quite often used as a last-resort treatment option for treating multidrug-resistant Gram-negative bacterial infections. Due to its widespread use, COL...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: A Selective and Sensitive Method for Colistin Detection by G-Quadruplex Ligand Competition

In @pubs.acs.org
With Nanjing U (CN) & @polytechniqueparis.bsky.social

@cnrs.fr @inserm.fr
doi.org/10.1021/acs....

Pharmacomodulation of G-quadruplexes in long non-coding RNAs dysregulated in colorectal cancer - BMC Biology Background Non-coding RNAs (ncRNAs) in human cells constitute a substantial portion of the transcriptome but do not lead to protein synthesis. Among them, long non-coding RNAs (lncRNAs, > 200 nucleoti...

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Pharmacomodulation of G-quadruplexes in long non-coding RNAs dysregulated in colorectal cancer
Thanks to @embo.org
With IITGN India
@cnrs.fr
👉 doi.org/10.1186/s129...

Near-infrared emitting aza-BODIPY fluorophores, impact of N,N-dialkylamino groups on the photophysical properties: synthesis, characterization, and computational studies The development of new fluorophores emitting in the near-infrared (NIR-I and/or NIR-II) region is currently a major focus of research in fields such a…

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Near-infrared emitting aza-BODIPY fluorophores, impact of N,N-dialkylamino groups on the photophysical properties: synthesis, characterization, and computational studies
With @ensdelyon.bsky.social, @ugrenoblealpes.bsky.social, @rennesuniv.bsky.social & @univ-nantes.fr

Bioorthogonal click chemistry-mediated conjugation of an anti-DR4 antibody to gold nanorods enhances its pro-apoptotic activity under near infra-red-light stimulation Pro-apoptotic receptor activators (PARAs), including second-generation agonist antibodies and ligands targeting the TNF receptor superfamily such as T…

𝐈𝐒𝐈 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲: Bioorthogonal click chemistry-mediated conjugation of an anti-DR4 antibody to gold nanorods enhances its pro-apoptotic activity under near infra-red-light stimulation
With ICB & @ctm-inserm-dijon.bsky.social
@cnrs.fr @inserm.fr
👉 www.sciencedirect.com/science/arti...