Today, we had the pleasure of welcoming Dr. Jakub Abramson from the Weizmann Institute of Science, as part of the 2025 CIML seminar series. Jakub gave a great seminar: “From Thymic Mysteries to Sex hormones - HECking the sexual dimorphism of the immune response” Thanks Jakub for your visit!
Today, we celebrate International Women’s Day in Science. To honor this day, we've created seven portraits of ♀️ scientists at CIML. Each portrait reflects their unique journey and contributions. Stay tuned for their inspiring stories. #WomenInScience @inserm.fr @cnrs.bsky.social @univ-amu.fr
Having a great time with the team !
#immunology #CIML
Thanks to @agencerecherche.bsky.social (ANRRANKLThym), Bristol-Myers Squibb Foundation and Fondation ARC for supporting our project !
We provide the proof-of-concept that RANKL stimulates human endothelial and epithelial cells using thymic organo-cultures, providing an exciting new therapeutic approach in the arsenal of regenerative medicine to rejuvenate the immune system.
This increased production leads to peripheral T-cell renewal and improves T-cell-mediated anti-tumor and vaccine responses in aged mice.
RANKL treatment in aged mice restores thymic architecture as well as cellularity and functional properties of endothelial and epithelial cells. This boosted T-cell production in the aged thymus.
The RANK-RANKL axis in the thymus is altered during aging. In addition to thymic epithelial cells, endothelial cells depend on RANK signaling for their cellularity and functional maturation.
Excited to share our 1st post ! Thrilled to share our latest research in Science Translational Medicine ! @science.org
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation
