Roel De Maeyer

Menopause reshapes women’s immune systems, leaving them vulnerable to infection. A new study has shown that HRT may help reverse these changes and boost immune health. https://www.ndorms.ox.ac.uk/news/hormone-therapy-may-help-restore-immunity-in-menopausal-women

It's #MenopauseAwarenessDay! Our new study exploring why women’s immune defences weaken after menopause offers some hope - suggesting that hormone replacement therapy (HRT) not only relieves symptoms, but those taking it had healthier immune systems in later life. https://f.mtr.cool/abqkylmndg

Hormone replacement therapy helps restore immune function in menopausal women, reducing inflammaging and preserving monocyte function. open-access
onlinelibrary.wiley.com/doi/10.1111/...

Extends what I previously summarized from immune system clocks
erictopol.substack.com/p/new-anti-a...

Such an overlooked area that needs much more attention. Major kudos and thanks to @emmaschambers.bsky.social for driving this work and here's to more exciting stuff in future!

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace...

New paper alert #immunosky 🚨
What happens to our immune systems as we get older? What happens after the menopause? Turns out monocytes are actually quite important in their own right!

Check out our paper in Aging Cell now:
onlinelibrary.wiley.com/doi/10.1111/...

Age-associated inflammatory monocytes are increased in menopausal females and reversed by Hormone Replacement Therapy Biological sex is a crucial, but poorly understood variable in age-related susceptibility to infections and chronic inflammation, inflammageing. Monocytes are important immune cells responsible for in...

If you have wondered how age, sex and even the menopause influences monocyte phenotype and function. Then our new preprint is for you www.biorxiv.org/content/10.1...

Enhancing immunity during ageing by targeting interactions within the tissue environment - Nature Reviews Drug Discovery Immune dysfunction increases with age owing to cellular senescence and low-grade inflammation, processes that drive each other during ageing. This Review discusses the potential of therapeutic approac...

First Bluesky post, and it's a good one!
Check out a brand new review in @naturerevdrugdisc.bsky.social on targeting tissue immune interactions to improve age-related immunity:
www.nature.com/articles/s41...