Isaac Jensen

Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites Human memory T cells persist in tissues as circulating and tissue-resident populations. Lam et al. reveal asynchronous aging of T cells across sites and subsets. Splenic memory T cells are longer-lived compared with mucosal sites and blood. Tissue-resident T cells demonstrate stable persistence, avoiding the acquisition of immunosenescent features seen in circulating subsets.

Online now: Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites

NK cells share a universal signature of memory with B and T cells. Come to my presentation at AAI to find out more.

Sunday April 4th 9:30am Room 316C
#AAI2025 #NKcells #ImmuneMemory

NIH freezes all research grants to Columbia University Amid negotiations with Trump, the university could risk losing nearly $700 million

Exclusive: Weeks after President Donald Trump’s administration ordered NIH to pull $250 million in biomedical research grants to Columbia University, the agency is freezing all remaining grant money owed to the university until further notice. scim.ag/4if5Rg1

The myth that the childhood vaccine against measles, mumps, and rubella (MMR) causes autism is based on a discredited study falsely linking the vaccine to autism. Find out more: ow.ly/EqeC50VlKva.

#ImmunologyExplained #Measles #MedSky #MMR

We strongly oppose the recent decision by NIH, under Acting Director Dr. Matthew Memoli, to reduce the reimbursement rate for "indirect costs" to 15% for all research institutions. Read our statement in full: ow.ly/JQig50UY71T

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO

Maintenance and functional regulation of immune memory to COVID-19 vaccines in tissues While vaccine-induced immunity circulates through blood, Davis-Porada et al. reveal that T and B cell memory generated by COVID-19 mRNA vaccines is stably maintained across lymphoid and mucosal tissues. Functionally, spike-reactive T cells exhibit heterogeneous effector and regulatory profiles compartmentalized in blood and tissues, respectively, for protection and tissue homeostasis.

Our collaborators chart the regulation of #immune memory to #covid19 in #lung and #lymphoid tissues. Authors include Peter Sims, Donna Farber, Alba Grifoni, Daniela Weiskopf and Alessandro Sette.
www.cell.com/immunity/ful...

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span Human tissue γδ T cells are diverse and functionally heterogeneous in early life and differentiate into disseminated effectors in adults.

ICYMI: earlier this year in #Science #Immunology, Josh Gray, Donna Farber & al. analyzed the phenotype, transcriptome, function, & repertoire of #gdTcells in mucosal & lymphoid tissues & blood from 176 #human donors across the life span! Subjects ranged in age from just a few days to over 80 years!