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Skyler Lentz

@skylerlentz

Critical Care and Emergency Physician, passionate about understanding and explaining abnormal physiology

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03.12.2023
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Latest posts by Skyler Lentz @skylerlentz

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23.02.2026 15:42 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Identifying optimal positive end-expiratory pressure by body mass index does not account for natural physiologic variability in pleural pressure Mechanical ventilation and selecting optimal positive end-expiratory pressure (PEEP) in patients across a wide range of body mass indexes (BMI) is cha…

What’s optimal PEEP for your patients with an increased BMI?

Our study showed a simple equation you can use:

PEEP = BMI/3

There’s variability, but BMI/3 approximates the mean optimal PEEP (by esophageal manometry) from BMI 25 to > 40

#EMIMCC #medsky

www.sciencedirect.com/science/arti...

23.02.2026 15:42 πŸ‘ 7 πŸ” 0 πŸ’¬ 2 πŸ“Œ 1

Yes, it will get you closer to the LV than guideline recommended hand

What remains unknown (for now) is would it take away from other important elements of the resuscitation (eg longer pauses) and would localization and hand placement over LV improve rate of ROSC or other outcomes

03.02.2026 02:01 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Transthoracic Echocardiography is Superior to AHA Guidelines Location in Identifying the Left Ventricle for Chest Compressions Standard CPR guidelines recommend chest compressions over the lower half of the sternum; however, this often results in compressions over the left ven…

What’s the best site for chest compressions?

Probably mid-LV

Guideline recommended location overlies the LV in the minority of cases

TTE may be a good tool to better localize mid LV and thus optimal compression location (esp if TEE unavailable)

#foamcc

www.sciencedirect.com/science/arti...

03.02.2026 00:43 πŸ‘ 3 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

Can you allow a MAP of < 65 in your patients with septic shock?

Yes! Maybe as low as MAP of 50

But you must examine to make sure they are perfused
-capillary refill < 3 seconds, warm extremities without mottling
-adequate urine output
-clearing lactate

#EMIMCC

journals.lww.com/ccmjournal/a...

02.01.2026 18:47 πŸ‘ 11 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Yes, I think I see this in the post op cardiovascular surgery population with Nicardipine

Unimpressive atelectasis with out of proportion hypoxemia

Interesting to think is there a titratable infusion that doesn’t cause it?

16.11.2025 20:44 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

#emimcc

13.11.2025 23:07 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Setting PEEP by BMI/3 might be a good starting point in patients with an elevated BMI

Understanding it may lead to over or under PEEP for about 2/3 of patients based on our OR population with variable BMIs

13.11.2025 19:41 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Adjustment of positive end‐expiratory pressure based on body mass index during general anaesthesia: a randomised controlled trial* Lung‐protective ventilation is essential for preventing postoperative pulmonary complications. While maintaining a low driving pressure and optimising PEEP is of importance, the ideal strategy remains contentious. This study evaluated whether ...

Other recent work in this area

pmc.ncbi.nlm.nih.gov/articles/PMC...

13.11.2025 19:41 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

The mean of esophageal pressure estimates of optimal PEEP surprisingly approximated the mean of BMI/3 in our >100 patients with BMI <25 to >45

BUT

BMI/3 would only capture about 1/3 of patients esophageal pressure base transpulmonary pressure optimal PEEP (tPP of 0 +\-2)

13.11.2025 19:41 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Identifying Optimal Positive End-Expiratory Pressure by Body Mass Index Does Not Account for Natural Physiologic Variability in Pleural Pressure Mechanical ventilation and selecting optimal positive end-expiratory pressure (PEEP) in patients across a wide range of body mass indexes (BMI) is cha…

Individualized PEEP:

Can you estimate optimal PEEP in any BMI with the simple equation of BMI/3?

Maybe!

Our new paper comparing esophageal pressure base transpulmonary pressure estimates of optimal PEEP (tPP of 0 +\-2) vs BMI/3 in OR patients

www.sciencedirect.com/science/arti...

13.11.2025 19:41 πŸ‘ 9 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Evaluation of Hydrocortisone Discontinuation Strategies in... : Critical Care Explorations ility differ among patients with septic shock undergoing abrupt hydrocortisone discontinuation compared with gradual tapering. DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort study conduc...

How do you stop hydrocortisone once septic shock has resolved?

I tend to be an abrupt discontinuation kind of person, stop as soon as the pressors are off rather than taper (unless it’s been a prolonged course)

Restrospective evidence πŸ‘‡

journals.lww.com/ccejournal/f...

18.08.2025 19:22 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Continuum of Preshock to Classic Cardiogenic Shock in the Critical Care Cardiology Trials Network Registry:

Answer: #2 normotensive cardiogenic shock

It’s sneaky, easy to miss but important to identify, diagnose cause, manage and admit to ICUβ€”not the floor tele unit

Occurs in about 12% of CS patients

Mortality 17%

www.jacc.org/doi/10.1016/...

10.08.2025 19:49 πŸ‘ 2 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Which has a higher mortality?

1. Patient with EF 30% BP 80/56 with lactic acid 1.8, normal LFTs, and warm extremities

OR

2. Patient with EF 30% BP 100/70 with lactic acid 3.8, elevated LFTs and cool distal extremities

10.08.2025 19:49 πŸ‘ 5 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

Excited to share our updated review of ECMO for the emergency clinician! Grateful for my excellent co-authors who shared their extensive expertise & time: @skylerlentz.bsky.social, Cameron Upchurch, Jenelle Badulak, Brit Long, and @mgottliebmd.bsky.social

authors.elsevier.com/a/1lFOI2dHVQ...

11.06.2025 18:54 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

β€œthe PaO2/FiO2 ratio was significantly lower in the group treated with lower tidal volumes on days 1 and 3” (ARDSnet)

But as we know 28 day mortality was eventually higher in the larger tidal volume group

I wonder what we’re doing now in medicine that is similar?

05.06.2025 01:38 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

What in critical care medicine do you think makes the patient look better in the short term but is actually worse in the longer term?

25 yrs ago we might have said look my patient with ARDS and 12 ml/kg tidal volume is oxygenating better, so it must be superior to 6 ml/kg

05.06.2025 01:38 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Post image

Intensivists and Respiratory Therapists: 🫁

What’s your go to tidal volume for the patient without ARDS and why?

6 ml/kg PBW
8 ml/kg PBW
10 ml/kg PBW
Something else?

10.05.2025 19:03 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Effect of Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in COPD This randomized clinical trial compares the effect of high-intensity noninvasive positive pressure ventilation (NPPV) vs low-intensity NPPV on the need for endotracheal intubation in patients with an ...

What’s the highest IPAP you’ll use with NIV in a patient with COPD and respiratory failure?

Before this trial I’d stop at ~ 20 cmH20, and think about intubating if not improving

After this trial:

Now up to 30 cmH20 may safely avoid intubation

jamanetwork.com/journals/jam...

30.03.2025 02:17 πŸ‘ 5 πŸ” 3 πŸ’¬ 1 πŸ“Œ 1
The Osmolal Gap: A Valuable Test for Identifying Toxic Alcohol-Induced Anion Gap Metabolic Acidosis Emergency physicians frequently encounter patients with undifferentiated anion gap metabolic acidosis, some of whom have been exposed to toxic alcohols. In 2022, according to the National Poison Data ...

The pro argument

www.annemergmed.com/article/S019...

09.02.2025 17:59 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The Osmolal Gap Has a Limited Role in the Evaluation of Possible Toxic Alcohol Poisoning

What’s the role of the osm gap in identifying toxic alcohol poisoning?

The con: We say it’s limited and all about the history and clinical course

www.sciencedirect.com/science/arti...

09.02.2025 17:59 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

What’s the highest temperature you’ve seen in clinical practice and what was the cause?

11.12.2024 01:33 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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a fire with the words way to add fuel written below it ALT: a fire with the words way to add fuel written below it

πŸ«€What happens when epinephrine is given before defibrillation in VT/VF arrest

journals.lww.com/ccmjournal/a...

09.11.2024 19:08 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Failed extubation?

I like to think of it as an intubation vacation

21.12.2023 12:51 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0