Anand Vaidya

🧠 Dr. Vaidya’s @anandvaidya17.bsky.social
practical approach to primary aldo, distilled into one clean, clinic-ready infographic:

This is high-yield, no-fluff, practice-changing stuff.

www.youtube.com/watch?v=mqpl...

Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism AbstractBackground. Normal-appearing adrenal glands on cross-sectional imaging may still be the source of aldosterone production in primary aldosteronism (

#ThrowbackThursday

Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism

academic.oup.com/ajh/article/...

#EditorsChoice from 2022 #OpenAccess #Free

Yes. This is a game changer. Beyond being able to replace AVS, it allows one to “see” the underlying pathological contributors to a large proportion of “idiopathic” hypertension. This is another piece of evidence that should make clinicians rethink the pathogenesis and treatment of hypertension

Podcast Episode: Primary Aldosteronism | HBP Guideline | JACC JACC’s November 4 issue features the High Blood Pressure Guideline surrounded by a series of expert commentaries. In this video interview, JACC Deputy Editor Erica S. Spatz, MD, FACC, speaks with author Anand Vaidya, MD MMSc. Listen in for an insider view of the evolving understanding of primary aldosteronism in light of the 2025 high blood pressure guidelines. Dr. Vaidya emphasizes that primary aldosteronism may be a common, modifiable contributor to hypertension—potentially affecting up to 25% of patients—and advocates for simplified diagnostic approaches and broader use of mineralocorticoid receptor antagonists to improve outcomes.

Podcast to accompany this editorial on primary aldosteronism: www.jacc.org/do/10.1016/0...

Is It Time to Retire Aldosterone Suppression Testing? Abstract. Primary aldosteronism (PA) is the most common endocrine hypertension. For decades, PA diagnosis has required proving nonsuppressibility of aldost

#WeekendReads from the Advance Articles section

Time to retire Aldosterone Suppression Testing?

academic.oup.com/ajh/advance-...

Is it time to retire confirmatory testing for primary aldosteronism? Abstract. Primary aldosteronism(PA) is the most common endocrine hypertension. For decades, PA diagnosis has required proving non-suppressibility of aldost

academic.oup.com/ajh/advance-...

Discordance and shortcomings of aldosterone suppression tests in primary aldosteronism AbstractBackground. The saline suppression test (SST) and the captopril challenge test (CCT) have traditionally been used to confirm or exclude primary ald

Confirmatory testing (aldosterone suppression testing) for primary aldosteronism: not reliable, or reproducible, for diagnosis or predicting lateralization. Sensitivity at the expense of specificity, and vice-versa. Time to simplify the process

academic.oup.com/ejendo/artic...

To accompany the new ACC/AHA BP guidelines, a practical guide on how to test for Primary Aldosteronism: now recommended for most people with hypertension.

www.jacc.org/doi/10.1016/...

An illustration from JAMA's review on adrenal insufficiency, dated June 16, 2025, showing normal and impaired hypothalamic-pituitary-adrenal axis physiology with mechanisms leading to adrenal insufficiency.

Adrenal insufficiency is a syndrome of cortisol deficiency.

This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis.

ja.ma/3HKk9Jr

Yes!

Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas Pheochromocytomas and paragangliomas (PPGLs) are rare chromaffin cell-derived neuroendocrine tumors of sympathetic (catecholamine-producing) or parasympathetic (nonsecretory) origin, frequently driven...

Don't miss the preprint from:
@alice.soragnilab.com
@michaelyehmd.bsky.social
@anandvaidya17.bsky.social
@nicolebechmann.bsky.social

🏥
@uthealthsa.bsky.social
@dgsomucla.bsky.social
@harvardmed.bsky.social
@mdanderson.bsky.social
@tudresden.bsky.social

www.biorxiv.org/content/10.1...

🩺 In NEJM, our interactive case on a common CC - evaluation of a patient with new pulmonary symptoms www.nejm.org/doi/full/10....

Congrats to star fellow Dr Joanne I. Hsu for leading & wonderful to learn from expert multi-D colleagues @anandvaidya17.bsky.social @harvardmed.bsky.social @nejm.org

Interactive Medical Case A Case of Crackles An illustration of the patient coughing in bed and her husband caring for her

A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. The night before presentation, she began to have chills and night sweats. Learn more and test your skills: nej.md/4mcUHuL

#ENDO2026 Welcomes Your Ideas | Our annual meeting will take place in Chicago, IL, June 13–16, and I’m inviting YOU to shape the program💡Submit your symposium proposal or session suggestion by Tuesday, September 2: bit.ly/4flCMjl
#endocrinology @TheEndoSociety

1/ Even outside of AVS the intra-individual variability of plasma aldo is important. Another study with the same message. www.ahajournals.org/doi/10.1161/...

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Variability of Aldosterone concentration while performing AVS

academic.oup.com/ajh/article/...

#Free #EditorsCHoice

Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study | Circulation BACKGROUND: Primary aldosteronism (PA), an overt form of renin-independent aldosterone production, leads to a disproportionately high rate of major adverse cardiovascular events (MACEs). Mounting evid...

Subclinical Primary Aldosteronism and MACE

www.ahajournals.org/doi/10.1161/...

You were right the first time!

www.acpjournals.org/doi/10.7326/... Confirmatory Testing for Primary Aldosteronism: A Study of Diagnostic Test Accuracy: Annals of Internal Medicine: Vol 178, No 7

New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic
academic.oup.com/jcem/advance...

The Impact of Modern Industrialized Dietary Sodium Intake on the Plasma Proteome

academic.oup.com/ajh/advance-...

A pragmatic approach to evaluate for ADRENAL INSUFFICIENCY

Thanks to @irinabancos.bsky.social and Jay Findling for lending their expertise!

Adrenal Insufficiency

For the minority of ppl with purely unilateral disease, RFA transcutaneous or EUS is a great option. But for all the rest, I suspect ASI will be the game changer. Medical “aldosteronectomy”

Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis | Hypertension Background: Confirmatory tests are recommended for diagnosing primary aldosteronism, but the supporting evidence is unclear. Methods: We searched Medline, EMBASE, and the Cochrane Central Register o...

and this SR/MA that makes the point: www.ahajournals.org/doi/10.1161/...

Targeting a Hormonal Cause of Hypertension | NEJM This interactive feature describes a woman who received a diagnosis of hypertension and preeclampsia at 27 years of age. After giving birth, her blood pressure remained elevated. Test your diagnost...

would suggest the following approach that obviates need for "confirmatory" testing
www.nejm.org/doi/full/10....

yes, same. as seen in this study: www.acpjournals.org/doi/abs/10.7...

Beautiful study. Stop the madness.
Low-renin hypertension is by far and away some manifestation of primary aldosteronism pathophysiology. Even if you get caught up in names and definitions and can't accept this, it responds beautifully to MR antagonist therapy, so just do the right thing.

Confirmatory Testing for Primary Aldosteronism: A Study of Diagnostic Test Accuracy: Annals of Internal Medicine: Vol 0, No 0 Background: Confirmatory testing to verify the diagnosis of primary aldosteronism (PA) in patients who have an abnormal screening result is of uncertain benefit. Objective: To perform a blinded assess...

In the @annalsofim.bsky.social

www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team

Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management)

#NephSky #EndoSky