Mike Martynowycz

…unacceptable. How is this allowed? #VSA2025 #QSA-19

The Frontiers of Structure

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The Frontiers of Structure | Science | AAAS www.science.org/content/blog...

Seed to sub-Å!
We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1...
#StructuralBiology #CryoEM

Whoa! Check out this bug!

Dog is 8

nightmare group chat

Energy filtering enables macromolecular MicroED data at sub-atomic resolution - Nature Communications High-resolution data are crucial for accurate structural modeling. Here, authors enhance MicroED data quality using energy filtering, achieving sub-atomic resolution protein data and uncovering diffus...

Our latest paper is out!

We combine direct electron detection and energy filtering to boost the SNR of our MicroED data

This work was done at HHMI and UCLA with @sciencemick.bsky.social who now runs his own lab at UB-HWI, Johan Hattne, and Tamir Gonen

www.nature.com/articles/s41...

Energy filtering enables macromolecular MicroED data at sub-atomic resolution - Nature Communications High-resolution data are crucial for accurate structural modeling. Here, authors enhance MicroED data quality using energy filtering, achieving sub-atomic resolution protein data and uncovering diffus...

Our work in Nature Comms demonstrates how energy filtering, plasma FIB, and direct electron detectors in counting mode can push MicroED to sub-atomic resolution!

Proud to have done this work back at UCLA. Hoping to bring similar capabilities to Buffalo.

📄 Read the paper: doi.org/10.1038/s414...

Ardem, I am sorry. In this middle of this chaos, HHMI will always hold the dubious distinction of being the first organization, federal or private, to cut an ongoing and funded DEI program. In the darkest hour, it ran for the hills. As a member of those groups, I can’t tell you how painful this is.

National Institutes of Health radically cuts support to universities Sudden and drastic change will make it hard for researchers to keep the lights on.

arstechnica.com/science/2025...

I’m happy to share that @HWMRI has merged with @UBuffalo. My lab will stay at HWI, and my title is changing. I’m starting a new position as a tenure track Assistant Professor at the Jacob’s School of Medicine at the University at Buffalo!

Comprehensive microcrystal electron diffraction sample preparation for cryo-EM - Nature Protocols We present a protocol for preparing microcrystal samples for cryo-EM diffraction imaging, including room temperature solid-state small molecules and soluble and membrane protein crystals.

Super happy to share our latest work! A detailed protocol for #MicroED sample prep available @NatureProtocols! It covers #FIB, grid making, sample handling, #CryoFLM, and more! Hope it helps!

www.nature.com/articles/s41...

‘No Way To Prevent This,’ Says Only Nation Where This Regularly Happens

‘No Way To Prevent This,’ Says Only Nation Where This Regularly Happens theonion.com/no-way-to-pr...

Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication - Nature Communications Virus-induced cellular condensates are poorly understood. Using cryoET and cryoEM, the authors visualized the 3D “molecular sociology” of host-virus interactions and choreographed mammalian reovirus a...

Excited to share our new work! We shed light on the sociology of virus-induced condensates supporting reovirus assembly and replication. Visualized using #CryoET #CryoEM and #FIBmilling

www.nature.com/articles/s41...

Great collab w/ @xianxia13 @zhou_lab Xiaoyu Liu @gonenlab

a man with a mustache is sitting on a swing in a park ALT: a man with a mustache is sitting on a swing in a park

Waiting for the next episode

“Lunch is cancelled due to lack of hustle!”

Would you please add me? Thanks!

Thanks!

Please add me to the list. Thank you!