Jane Dudley

Heatwave in London as seen from the Crick’s roof terrace at lunchtime ☀️

Do you want to hear more about ubiquitin? Are you free on Friday 14:00 BST? If so, why not join the Biochemical Society early career researcher webinar series where my fellow UCL alumnus Michele Frison and I will be presenting! 💻 💡

Registration: register.gotowebinar.com/register/821...

Fascinating and diverse programme of talks at the joint Autophagy UK and @ukproteostasis.bsky.social meeting in Dundee this week! & super happy to have the chance share our #pseudoligase work 📣

If you're in #immunity #cancer #neurodegeneration or #TPD fields, this might just tickle your fancy:
❓What are the biochemical functions TRIM proteins that have been implicated in these diseases?
❓What are the key catalytic features of RING domains?
❓Which TRIMs could work as #PROTAC components?

Identification of RING E3 pseudoligases in the TRIM protein family Nature Communications - Understanding the catalytic and regulatory mechanisms of the ubiquitin system is key to tapping into its therapeutic potential in diseases where its dysfunction is...

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

As a geneticist, I will not mourn 23andMe and its jumble of useless health information | Adam Rutherford Millions paid to give away their most personal data. At least in return they found out more about their earwax, says academic and author Adam Rutherford

Well put!
theguardian.com/commentisfre...

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

Joint 2025 Autophagy UK and Proteostasis UK conference | University of Dundee, UK Welcome to the 2025 joint “Autophagy UK and Proteostasis UK” conference!

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs
Register here: tinyurl.com/mr3p49f9

Ubiquitin—A structural perspective Ubiquitin is a cellular modification that comes in many forms. In this review, Agrata and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin, alongside ensemble and molec...

Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...

Mixing a leaving party with our Christmas party; house music with high res imaging… #Crickmas @crick.ac.uk

Thanks so much! Such a lovely idea ☺️ can’t wait to tuck into these over the holiday…

Christmas is looking very jolly here at the Crick! @thecrick.bsky.social 🎄✨ takes the edge off early starts with such short daylight hours…

Graphic logo for "Brain Rot" featuring stylszed text and a decorative emblem above the word "brain." The background is solid blue bordered by a dotted line.

Image showing a dictionary-style entry for the term "brain rot," defined as an intellectual deterioration viewed as a result of overconsumption of trivial or unchallenging online content, potentially leading to further cognitive decline. The word is highlighted in bold with a graphic of a brain with ice cream elements above it.

CONFIRMED: Oxford University Press select 'brain rot' as the 2024 Oxford Word of the Year 🧠📱

#OxfordWOTY