Pauline M.L. Coulon

Profiling of Burkholderia pseudomallei variants derived from Queensland’s clinical isolates | Microbiology Spectrum Burkholderia pseudomallei (Bp), the causative agent of melioidosis, is endemic to Australia, Asia, Africa, and the Americas. It predominantly affects Indigenous populations and individuals suffering f...

I am excited to share that my fourth paper of 2025 is finally out. Perfect timing to conclude the year.

journals.asm.org/doi/10.1128/...

Profiling of Burkholderia pseudomallei variants derived from Queensland’s clinical isolates | Microbiology Spectrum Burkholderia pseudomallei (Bp), the causative agent of melioidosis, is endemic to Australia, Asia, Africa, and the Americas. It predominantly affects Indigenous populations and individuals suffering f...

I am excited to share that my fourth paper of 2025 is finally out. Perfect timing to conclude the year.

journals.asm.org/eprint/8YRDZ...

Co-isolation of genetically distinct Burkholderia pseudomallei strains from a single patient in North Queensland While investigating colony morphology variation within clinical isolates of Burkholderia pseudomallei (Bp) isolated from a single clinical infection, we identified two distinct strains (based on their...

Finally out in @PLOSONE!
I would like to thank my co-authors and the reviewers for helping us improved the article.

journals.plos.org/plosone/arti...

Pseudomonas aeruginosa, my model for research on quorum sensing, biofilms, and opportunistic infections | Journal of Bacteriology With encouragement from the Journal of Bacteriology Editor in Chief, George O’Toole, I have written this short essay in a style different than Journal of Bacteriology articles on model organisms. It i...

I have just read Prof E. Peter Greenberg latest editorial paper, explaining why he has been working on P. aeruginosa.

That is very refreshing to hear how research is also impacted by interpersonal relationships and personal events.

We should hear more about it.

doi.org/10.1128/jb.0...

🚨 New preprint out!
Proud to share the first reported clinical case of polyclonal #melioidosis infection in QLD—also the first study applying integrative multi-omics at the bacterial level.

🧬 Time to advance diagnosis & build a multi-omics database!

Type VI secretion system activity at lethal antibiotic concentrations leads to overestimation of weapon potency Competition assays are a mainstay of modern microbiology, offering a simple and cost-effective means to quantify microbe–microbe interactions in vitro. Here, we demonstrate a key weakness of this meth...

Does your lab perform killing assays?
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...

1/n

"What makes S. aureus such a difficult vaccination candidate?" Here are some answers:

I am very excited to share our latest preprint on ⬇️

<em>Respirology</em> | APSR Respiratory Medicine Journal | Wiley Online Library Click on the article title to read more.

Melioidosis in Asia-Pacific Nations: Expanding Boundaries but Unknowns Remain

By Bart Currie and Ella Meumann

doi.org/10.1111/resp...

Exploring the Gut-Lung Axis in Health and Disease In this webinar, George O’Toole and Jorge Cervantes will discuss how researchers study the communication between the gut and lung in normal and disease states.

A few days ago I had the chance to talk about our work on the gut-lung axis in cystic fibrosis as part of a webinar with The Scientist magazine. You can check it out here (I am the first speaker): www.the-scientist.com/exploring-th...

Structural and Synthetic Biology We are interested in understanding molecular mechanisms, especially those that are linked to human disease. We use a multi-disciplinary approach to dissect structures and functions of large macromole...

The Section of Structural and Synthetic Biology at Imperial College is seeking to support candidates for leading their own laboratory through independent fellowship schemes eg Wellcome Trust, MRC Career Development Award, UKRI Future Leaders Fellowships www.imperial.ac.uk/infectious-d...

Phylogenomics, evolution and origin of multidrug-resistant Acinetobacter baumannii ST15 We studied the genomic evolution and transmission dynamics of multidrug-resistant ST15 (Institut Pasteur scheme) Acinetobacter baumannii, examining resistance gene acquisition, clonal diversification,...

New paper in Microbial Genomics!
Amazing work by @eradah.bsky.social & @liamtobin1.bsky.social & another great collaboration with François Lebreton & Patrick McGann. Here is the link: microbiologyresearch.org/content/jour...
#AMR #Acinetobacter
@aimi-uts.bsky.social

Les bactéries miroir vont-elles détruire toute vie sur Terre ? Les scientifiques réagissent YouTube video by Le Blob

Super proud to be featured in this outstanding video about the risks of and dialogue around mirror bacteria by the amazing @leblob.bsky.social team.

I wasn’t confident enough in my French for my interview, merci for the subtitles!

youtu.be/DUW-Q-w1FUw?...

Methylation: Modifying gene expression through passive forces The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

Modifying gene expression through passive forces 🧬🧪

Passive forces, like where and when mRNA degrades, play a key role in m6A dynamics, without always needing active editing.

Understanding and predicting microbial evolutionary dynamics - 2025 meeting

This meeting will be great!

Abstract submission open now

See you 26-27 Nov in Liverpool

microbiologysociety.org/event/societ...

Update: the seminar will be held in room 320 level 3 building 4

Hi everyone, just a quick reminder about @aimi-uts.bsky.social hosting Prof Leo Eberl next week for an @asm-nswact.bsky.social event!

Thanks to @garry-myers.bsky.social @aimi-uts.bsky.social for supporting this work!

Thanks @evolvedbiofilm.bsky.social for posting our review!

We wanted to raise awareness that CMV are common in #Burkholderia —yet still understudied. Not accounting for this diversity can impact the long-term effectiveness of new therapeutics.

Please enjoy and celebrate the amazing work done so far by #Burkholderia researchers exploring colony morphology!

So grateful to have worked with Dr Kirsty Agnoli on this review on colony morphotype variation in #Burkholderia!

I've made my submission to the review of the ARC grant system. Have you?

5 more days, people.

Dear colleagues and friends, as the situation continues to deteriorate, we rise to defend academic freedom and stand unwaveringly for science.
Now, more than ever, our voices matter. ✊📚🧬
#StandUpForScience
Thursday 3rd in France👇
standupforscience.fr/la-journee-d...
@standupforscience.bsky.social

Hi everyone! This is official, with the participation of @asm-nswact.bsky.social , @aimi-uts.bsky.social will host Prof Leo Eberl from the Univ of Zurich to talk about the most fascinating bacteria: #Burkholderia
Please register for this exciting event!!!!!

Hi everyone! This is official, with the participation of @asm-nswact.bsky.social , @aimi-uts.bsky.social will host Prof Leo Eberl from the Univ of Zurich to talk about the most fascinating bacteria: #Burkholderia
Please register for this exciting event!!!!!

The elimination of federal science and health employees is a direct attack on scientific integrity, expertise and public trust. We stand in support of the career public servants who have dedicated their lives’ work to ensuring U.S. health, safety and security: asm.org/Press-Releas...

Hi #Burkholderia folks! Got cool B. pseudomallei phenotypes on blood & milk agar during my visit to @Dr Patrick Harris lab (Thanks to @isme-microbes.bsky.social). Any ideas on what’s being secreted? #microbiology

Cancelled NIH grant information submission form Please use this form to submit information identifying specific NIH grants that have been cancelled for any reason after January 20, 2025. Data from this form will be used to update the Rescinded NIH...

Please please please continue to submit details of your terminated grant using this Google Form 👇

Your submissions continue to be key to understanding patterns of grant terminations and facilitating advocacy and litigation. 💪💪💪

A PCA plot showing that while many genes are important for fitness in both infections models, some are only necessary in one model.

Essential genome of Burkholderia cenocepacia in our cystic fibrosis lung model vs. in waxworm - there are some subtle differences in fitness determinants between these infection models. journals.asm.org/doi/10.1128/... #MicroSky

What a great idea! This scheme is already competitive, asking ECRs to have senior researchers’ track records and they want us to secure employment before accessing the scheme while only 2 years postdoc are available if available… What about ECRs going overseas?