Congratulations to @nmaziak.bsky.social, @vaquerizasjm.bsky.social et al: Pico-C (low-input Micro-C) shows 3D genome architecture reorganises before major zygotic genome activation in Drosophila, with early loop formation and stronger insulation.
@natgenet.nature.com: www.nature.com/articles/s41...
Glad to have contributed to this work, and big thanks to @amathelier.bsky.social, @damlaob.bsky.social, and @ievarau.bsky.social (and the whole JASPAR crew) for this great effort.
#JASPAR #TFmotifs #DeepLearning #Genomics
π§΅2/2
JASPAR 2026 is out π
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
π§΅1/2
How do new centromeres evolve while staying compatible with the division machinery?
Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.
π doi.org/10.1038/s41586-025-09779-1
Congrats on the amazing work @jgahan.bsky.social and the team!
I am very proud to see @kkajan.bsky.social and Marta Bosnjakovic from my group presenting their exciting results obtained from #CAGE data!
#CroAGE #nextGenerationEU
To recognise and celebrate @svobodalab.bsky.social's pivotal contribution to Woodstock Bio2 + Night Science, #TCTeAC, I am starting this "What Petr Svoboda did at Woodstock?" thread. If you were there - #contribute and #retweet.
"Petr Didnβt Submit an Abstract. #TCTeAC Submitted to Him."
π¦ @kkajan.bsky.social is exploring promoter usage during early avian development in #EvolCompGen. #ISMBECCB2025
π Scaling CAGE analysis across tens of #DANIO-CODE samples with the @nf-co.re inspired CAGEflow pipeline βbig data meets promoters. Catch Ira's poster D-515! π¦π
π¦π Building the first promoter atlas of adult zebrafish organsβexpanding #DANIO-CODE. Visit Marta at poster C-514. #zebrafish #CAGE
π€ @da-bar.bsky.social is exploring AI-driven promoter architecture characterisation from CAGE! Come chat at poster D-507 at #ISMBECCB2025 @iscb-regsys.bsky.social
π The CroAGE team is attending to Liverpool for #ISMBECCB2025! Catch our CAGE & promoter research posters all week at ACC Liverpool. Thank you #nextGenerationEU for the opportunityπ§΅
Do we really need large language models to tell us that the germline residue is the optimal one? One of the questions Charlotte Dean tackled in her talk at #ISMBECCB2025, and how she and her team addressed the problem of germline bias in antibody target prediction π§¬π¬π»π€
Today marks the start of the #RegSys @iscb-regsys.bsky.social track at ##ISMBECCB2025! Very much looking forward to listening to the exciting science that will be presented.
Join us in room 11BC today and tomorrow.
π¨ We're hiring! NCMBM @ncmbm.bsky.social is looking for 2 new group leaders to join our vibrant research community. Ready to build your own group with strong support and a solid startup package?
Interested and attending #ISMBECCB2025? Letβs connect!
π www.jobbnorge.no/en/available...
Day 3 of #ISMBECCB2025 started with an excellent talk from @jameszou.bsky.social which presented how AI can form virtual labs to discuss problems, how can AI reanalyse research data to get new biological results, and how we can interpret complex AI predictions π»π€
Today's keynote at #ISMBECCB2025 Amos Bairoch talking about 45 years of data curation #swissProt #cellosaurus
Eagerly waiting for the start of #ISMBECCB2025 with @croage.bsky.social team, @kkajan.bsky.social, Marta and Ira, with the great company of @damlaob.bsky.social and @ferenckata.bsky.social for a keynote talk from John Jumper π§¬π¬
Meet our team!
π¨βπ¬ Dr. Damir BaranaΕ‘iΔ β Project Leader @da-bar.bsky.social
π¬ Dr. Matija PiΕ‘korc β Research Associate
π©βπ¬ Dr. Katarina Kajan β Postdoc @kkajan.bsky.social
𧬠Marta BoΕ‘njakoviΔ & Ira Renko β PhD candidates
Using cutting-edge technologies like CAGE (Cap Analysis of Gene Expression) and AI-driven algorithms, we aim to develop tools to explore promoter architecture & identify novel antitumor targets.
π Introducing CroAGE β a #NextGenerationEU project advancing regulatory & comparative genomics in ππ· Croatia! We study gene promoters to understand how they control development & how tumours disrupt transcription.
π croage.eu/en
Now, I hope to see you at #ISMBECCB2025! Please make sure to come to poster D-507 to say "Hi"! ππ§¬π¬
Finally, as a new member of the @embo.org YIP, it was an excellent opportunity to meet fellow EMBO YIP members and network with my peers through excellent science at the #EMBO YIP Annual Meeting in Heidelberg. I am looking forward to exciting new collaborations
Then, at the Origin of Metazoans in @sbroscoff.bsky.social I presented the promoter features of a Metazoan relative, Creolimax fragrantissima. The result of collaboration with @alexdemendoza.bsky.social, @borislenhard.bsky.social and @bzunar.bsky.social
It all started with the legendary #TCTeAC where I presented how we rediscovered TATA box using AI!
Oh boy, what an intensive and exciting June is behind me!! After three excellent meetings, including #TCTeAC, the Origin of Metazoans at @sbroscoff.bsky.social, and finally the @embo.org YIP annual meeting, #ISMBECCB2025 you are next!!! π§΅
Extremely proud to be part of this story! π§¬π₯ Our @nature.com paper, led by Will Scott @mrc-lms.bsky.social , maps 171k nuclei in human fat. Weight loss reverses senescence & reignites metabolic flux, but macrophages remain primedβclues for future therapies. www.nature.com/articles/s41...
I am glad to announce that the #DANIO-CODE Data Coordination Center is back online at a new home:
danio-code-dcc.genereg.net
Thank you all for your patience and sorry for any inconvenience!
I am happy and extremely proud to be able to contribute to this work with IrΓ¨ne Amblard and @vmetzis.bsky.social, where by changing one motif we completely rewired the function of a regulatory element!π¬π§¬ Now out in Developmental Cell!
What do you write at the end of the #TCTeAC survey email?
