Atul Deshmukh

Amazing Natalie,congratulations to you and your team 👏

Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease Targeting muscle with Cathepsin B (Ctsb) to treat the AD mouse brain. In this study, an AAV-vector-mediated approach, utilized to express Ctsb in muscle, prevented mnemonic and neurogenic deficits an...

I am excited to see our latest collaborative work in Aging Cell

doi.org/10.1111/acel...

We explored muscle–brain cross-talk and discovered that the muscle-derived cathepsin B (a myokine) plays a key role in improving behavioral and neurogenic deficits in a mouse model of Alzheimer’s disease.

Skeletal muscle proteomics: considerations and opportunities npj Metabolic Health and Disease - Skeletal muscle proteomics: considerations and opportunities

Are you interested in #proteomics and #skeletalmuscle? It can be a real pain to get deep reproducible coverage. Check out our review with @adeshmukh.bsky.social We analyse some considerations including current limitations and how to potentially overcome them #myoblue @unimelbcmr.bsky.social

Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…

New publication!

We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake.

www.sciencedirect.com/science/arti...

@cbmr.science @jeppekjaergaard.bsky.social

Body Fluid Proteomic Landscape of Acute Exercise Physical activity improves health, yet the molecular mechanisms remain partially understood. This study presents a high-resolution, time-resolved atlas profiling 10,127 proteins across plasma, saliva,...

Preprint Alert
We present the most comprehensive, time-resolved atlas of the human proteomic response to acute exercise. We mapped 10,000+ proteins across plasma, saliva & urine—3,000+ changed after just one workout.
doi.org/10.1101/2025...
Explore cbmr-rmpp.shinyapps.io/exerome/

Personalized molecular signatures of insulin resistance and type 2 diabetes Muscle samples from over 120 people were analyzed to identify molecular patterns linked to insulin resistance, a key feature of type 2 diabetes. The findings reveal new insights that could help tailor...

Getting to the basis of insulin resistance at the individual level via muscle biopsy and mapping the proteins
www.cell.com/cell/fulltex...

Scientists discover unique molecular fingerprints of insulin resistance Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes.

Highlighting our latest research.
Deconvoluting insulin signaling in human skeletal muscle.
www.news-medical.net/news/2025052...

Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.

@annakrook.bsky.social @juleenrzierath.bsky.social
@cbmr.science

doi.org/10.1016/j.ce...

Excited to share another great collaborative effort — we successfully combined single muscle fiber proteomics with functional assays in the same fiber! This integrated approach allows a direct link between molecular composition and functional performance at the single cell/fiber level.

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…

Latest from Jonas Treebak and team @cbmr.science

NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

I am happy to have contributed to this exciting work by applying our single muscle fiber proteomics workflow.

Fiber Type–Specific Adaptations to Exercise Training in Human Skeletal Muscle: Lessons From Proteome Analyses and Future Directions Skeletal muscle is a key determinant of sports performance. It is a highly specialized, yet complex and heterogeneous tissue, comprising multiple cell types. Muscle fibers are the main functional cel...

Fiber Type–Specific Adaptations to Exercise Training in Human Skeletal Muscle: Lessons From Proteome Analyses and Future Directions
onlinelibrary.wiley.com/doi/10.1111/...

Fiber Type–Specific Adaptations to Exercise Training in Human Skeletal Muscle: Lessons From Proteome Analyses and Future Directions Skeletal muscle is a key determinant of sports performance. It is a highly specialized, yet complex and heterogeneous tissue, comprising multiple cell types. Muscle fibers are the main functional cel....

Excited, share this review article with Morten Hostrup, where we discuss fiber type–specific muscle adaptations to exercise using single-fiber and pooled fiber proteomics.
Review also highlights key bioinformatics/statistical considerations!

doi.org/10.1111/sms....

@adeshmukh.bsky.social, recipient of the 2019 #EFSD/@novo-nordisk.bsky.social Future Leaders Award, explores how exercise regulates the skeletal muscle interstitial fluid #proteome, uncovering new treatments for #diabetes & #sarcopenia.

His latest study highlights LL-37’s role in muscle growth:
👇👇

A picture of stained skeletal muscle.

💪 𝐑𝐞𝐭𝐡𝐢𝐧𝐤𝐢𝐧𝐠 𝐌𝐮𝐬𝐜𝐥𝐞: 𝐍𝐞𝐰 𝐬𝐭𝐮𝐝𝐲 𝐜𝐡𝐚𝐥𝐥𝐞𝐧𝐠𝐞𝐬 𝐨𝐥𝐝 𝐜𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬

🔬 Our current approach to dividing muscle fibers into separate types may need to be revised following new research in Nature Communications by a team of scientists, including AssocProf Atul Deshmukh.

👇

www.nature.com/articles/s41...

I am excited to share our new publication where we analyzed transcriptome and proteome of >1000 single muscle fiber. Study explore the remarkable heterogeneity beyond traditional myosin heavy chain classifications.
Huge thanks to everyone who contributed.

Temporal dynamics of the interstitial fluid proteome in human skeletal muscle following exhaustive exercise Exercise regulates the human skeletal muscle interstitial fluid proteome in a distinct temporal manner.

I am excited to share our latest publication in Science Advances!

We mapped the proteome of interstitial fluid across the leg in response to exhaustive exercise, and discovered immune cell derived peptide regulating muscle growth.

www.science.org/doi/10.1126/...

5,562 proteins were found to have tissue-specific enrichment across 32 human tissues.

◼️ The majority of them (3,088) are enriched at the protein but not RNA level.

🧠 The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.

Proteomics of body fluids like saliva offers immense potential for biomarker discovery, as saliva is easy to collect, non-invasive, and rich in secreted factors.

Using a 21-minute MS method, we identified >4500 proteins highlighting saliva's untapped potential for diagnostics.

First post on this platform.

Excited to our manuscript where we used cutting-edge proteomics to map human & bacterial proteomes in saliva, revealing signatures of #Type2Diabetes

Arricle- rdcu.be/d5U3u
Video- shorturl.at/cSUCD

I am very grateful to my collaborators.