Pablo Msellem

A Gold-PROTAC Degrades the Oncogenic Tyrosine Kinase MERTK: Insights into the Degradome from a Steady-State System Proteolysis targeting chimeras (PROTACs) are bifunctional molecules designed to induce the degradation of specific proteins within a cell. While most PROTACs are noncovalent interactors, covalent PROT...

A Gold-PROTAC Degrades the Oncogenic Tyrosine Kinase MERTK: Insights into the Degradome from a Steady-State System | ACS Chemical Biology pubs.acs.org/doi/10.1021/...

Our work on the unidirectional motion of a CD is now in the September issue of Chem and on the cover!
Many thanks to the whole team and @cp-chem.bsky.social for the highlight!
@ipcm-sorbonne.bsky.social @msollogoub.bsky.social @enxuliu.bsky.social

www.cell.com/chem/fulltex...

Ready for a great conference #yISPPCC2025 #ISPPCC2025 ! Couldn't dream of a better setting than the sun of Sicily for a photophysics week 🌤👨‍🔬 #ChemSky

Vers des moteurs moléculaires unidirectionnels contrôlés chimiquement Fascinés par le fonctionnement des moteurs biologiques comme la kinésine ou l’ATP-synthase, protéines essentielles à

Our paper about cyclodextrins moving unidirectionally in @cp-chem.bsky.social highlighted by the CNRS (in French)

www.inc.cnrs.fr/fr/cnrsinfo/...

(1/4)🚨 Ecstatic to share that Max’s work on #photoswitchable #metallo-supramolecular helicates, with #self-sorting, a #MolecularRatchet and #out-of-equilibrium structures, is now out in @angewandtechemie.bsky.social

👀 doi.org/10.1002/anie...
#ProudPI
#SupramolecularChemistry
#ChemSky
#WomenInSTEM

Not going back: Unidirectional movement by intramolecular one-way ratcheting of functionalized cyclodextrin The achievement of unidirectional molecular movement is a significant challenge due to competition by Brownian motion. Nature can overcome this proble…

More than happy to share this work on the unidirectional movement of a functional cyclodextrin on an axle in Chem @cp-chem.bsky.social ‬ ! Congratulation to @enxuliu.bsky.social and all the team!!! www.sciencedirect.com/science/arti... @ipcm-sorbonne.bsky.social @sorbonne-universite.fr

Not going back: Unidirectional movement by intramolecular one-way ratcheting of functionalized cyclodextrin Achieving unidirectional molecular movement is a major challenge, often requiring molecular ratchets. Here, we exploit the unique 3D structure and selective functionalization of cyclodextrin to achieve unidirectional motion in a rotaxane system. The cyclodextrin enables one-way gate opening and promotes forward movement via a double-gated ratchet mechanism. These findings pave the way for more efficient rotary molecular motors in cyclic systems and could enable long-range translational motion at the molecular scale.

Online now: Not going back: Unidirectional movement by intramolecular one-way ratcheting of functionalized cyclodextrin

Design of porous self-assembled homoleptic and heteroleptic Pd2+ cages incorporating silicon-based fluoride acceptors: the way towards nuclear imaging applications Supramolecular self-assembly is a promising tool to develop multifunctional theranostic agents and has recently entered the field of radiochemistry. In this work, lantern-shaped [Pd2L4]4+ metallacages...

Check out our latest study on Pd-cages for dual-modality imaging including cool MS analysis and fancy in ovo PET imaging, doi.org/10.1039/D5QI...
Congrats to Marike Drexler, Luisa Ronga, Ioannis Kanavos, @gmalcantar.bsky.social Daniela Kraus @timwitney.bsky.social! EIC Pathfinder #SMARTdrugs

Excited to share our latest work now out in Chem! A functionnalized CD that moves unidirectionally by actively opening the way in only one direction. Huge thanks to @enxuliu.bsky.social and the team! @ipcm-sorbonne.bsky.social @msollogoub.bsky.social

www.sciencedirect.com/science/arti...

Biopharma dives into tumor-seeking radioactive drugs Nature Biotechnology - Big pharma and investors are piling into the precision radiation space as the next generation of increasingly potent targeted α-particle therapies promises to destroy...

Extremely honoured to have our work on supramolecular radiopharmaceuticals highlighted in the latest news in Nature Biotechnology!!! Thank you to the EIC Pathfinder SMARTdrugs @timwitney.bsky.social @hollandlab.bsky.social Alex Poot (UMCU) @cicbiogune.bsky.social Jordi Llop ! rdcu.be/emCW6

Take two polls to help Iupac define molecular machines An Iupac committee wants your input to guide its recommendations for key terms in the field

The 2016 Nobel prize in chemistry was awarded 'for the design and synthesis of molecular machines'. Ironically, we do not know exactly what constitutes a molecular machine. With the ultimate goal of unifying definitions and standardising terminology, Iupac needs your help!
#ChemSky #ScienceSky

Transducing chemical energy through catalysis by an artificial molecular motor - Nature A cross-linked polymer gel driven by artificial molecular motors transforms chemical energy into mechanical force, achieving powered contraction and re-expansion, demonstrating a considerable advance ...

New paper out in Nature 😃

Designing molecular catalysts to produce mechanical work on all scales.

Collaboration @giusepponelab.bsky.social / @profdaveleigh.bsky.social
within ITN ArtMoMa

www.nature.com/articles/s41...

🙏 Peng-Lai, Stefan, Martin, Alessandro

@cnrs.bsky.social
@unistra.fr

I am very proud to announce that the first article out of my PhD work is out in #JACS ! 🤩

Take a look : doi.org/10.1021/jacs...

Thank you to everyone who participated in this beautiful paper 😄 @vivesgui.bsky.social
@ipcm-sorbonne.bsky.social

#ChemSky #RealTimeChem

Sequential and Time-Controlled Sol–Gel Transitions by Mechanical Switching of Molecular Tweezers Controlling the motion of molecular machines to influence higher-order structures is well-established in biological systems but remains a significant challenge for synthetic analogs. Herein, we aim to harness the mechanical switching of switchable molecular tweezers to modulate their self-assembly and produce stimuli-responsive organogels. We report a series of terpy(Pt-salphen)2 molecular tweezers functionalized with alkyl chains that act as low-molecular-weight gelators (LMWGs) in their open conformation. The resulting organogels were thoroughly characterized by SEM, cryo-TEM, SAXS, and rheology. The macroscopic transition from gel to solution was achieved by the cation-induced closing of the tweezers, which triggers their substantial structural reorganization. Reversible sol–gel transitions were achieved through the sequential addition of chemical stimuli or by a decomposable acid in a time-controlled operation. Such transient disassembly process regulated by a chemical fuel enables multiple gelation cycles with minimal waste while maintaining stable rheological properties. These results underscore the potential of switchable molecular tweezers in creating advanced stimuli-responsive materials.

Excited to share our latest paper now out in #JACS! Using switchable molecular tweezers to control self-assembly and achieve reversible sol-gel transitions.
Huge thanks to @msellemp.bsky.social, Geoffrey, Louise, Nate & Clément! @ipcm-sorbonne.bsky.social #ChemSky
pubs.acs.org/doi/10.1021/...

Peng-Lai, @stefanborsley.bsky.social, Martin & our collaborators Alessandro and @giusepponelab.bsky.social demonstrate how a catalyst transduces chemical energy to perform mechanical work in www.nature.com/articles/s41... in @nature.com. tinyurl.com/jny7nen5. Animation @scicommstudios.bsky.social😀

PhD projects available in a range of areas - something for everyone! Join us to do cool chemistry using the mechanical bond in catenanes and rotaxanes for real world applications in the shiny shiny new Molecular Sciences Building @uobchemistry.bsky.social 😊 Reposts appreciated! #chemsky

Substitution Pattern of the Secondary Rim of ICyD Ligand Influences Stereoselectivity. Congratulations Guangcan Xu! I am glad this is out. #ChemSky
chemistry-europe.onlinelibrary.wiley.com/share/KKR9FK...

Congratulations Kajetan Bijouard for the nice paper! A great collaboration with Thibault Cantat and Lucile Anthore-Dalion! Glad this is out !

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...