Christy Niemeyer, PhD

My new article on @sciencerabbit.bsky.social discussing why women make up 2/3 of all Alzheimer’s disease patients.

Today’s STEM Day at the capital was a success! My students worked so hard on making posters that were accessible and highlighted all the important work we are doing! @projbridgeco.bsky.social @cuanschutz.bsky.social

The Link Between Shingles and Stroke Explained Prof. Andrew Bubak (PhD, MS) - The varicella zoster virus (VZV), primarily known for causing chickenpox and shingles, can reactivate and significantly increase stroke risk. Studies indicate a heighten...

Check out this article on @sciencerabbit.bsky.social giving a deep dive into The Link Between Shingles and Stroke sciencerabbit.org/2025/02/20/s...

Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11 - Nature Microbiology HD5 induces filopodial extensions in epithelial cells that the pathogen Shigella exploits to facilitate invasion and infection.

OUT NOW: Human enteric α-defensin 5 interacts with colonic epithelial receptor P2Y11 to induce filopodia and promote Shigella infection

by Kai Ye & co

www.nature.com/articles/s41...

White House pauses all federal grants, sparking confusion The Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments.

I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service.

“Pausing” grants means people don’t eat.

NIH memo addresses ‘confusion’ about restrictions imposed by Trump, easing some concerns Memo from acting director to staff allows some purchasing, and suggests travel and study sections could soon resume

“Shock and awe” at NIH returns to a new version of routine existential terror…

www.science.org/content/arti...

Now that we’re on Bluesky, it’s a good time to bring back #badsciencedrawings – a collection of figures that prove that science is more science than art.
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed

Morales-Botello et al., 2012

How much of age associated #microglia dysfunction in #Alzheimers disease is due to activation of LINE retrotransposons? Fun #openaccess study exploring this hypothesis - worth a read.
#neuroinflammation #neurosky

In #neuroinflammation, lineage matters….check out this preprint of long term engraftment of blood derived- #macrophages vs brain resident #microglia in #TBI
# neuroskyence

Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.

www.science.org/doi/10.1126/...

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...

👏 to Tetsuo Hasegawa & others of Clatworthy lab
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease - Nature Neuroscience Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s disease, shining l...

www.nature.com/articles/s41...

Fluorescent Friday brought to you by microglia (🟢) surrounding HSV-1 infection (🟣) and counterstained with DAPI (🔵). Taken from our recently published paper. journals.asm.org/doi/10.1128/...

This threaded discussion on sex differences in mechanisms leading to Alzheimer’s disease and neurodegeneration is worth a read. #microglia, #neuroinflammation

I love how kind everyone is on Bluesky! X is giving #reviewer2 vibes and Bluesky is like a kind reviewer 1! #Academia #endFTD

I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start.

Electron microscopy image of a mouse microglia marked with Iba1

I like microglia and I like electron microscopy. Today my new review on microglia ultrastructure came out on Open Biology.

doi.org/10.1098/rsob...

I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM

#microglia #electronmicroscopy
#tremblaylab

Virologist here! Would love to be added! Thanks!

Just joined and happy to see our recent work highlighted here!

Persistently primed microglia restrict the reactivation of latent cytomegalovirus at the expense of neuronal synaptic connectivity #singlecell
https://www.researchsquare.com/article/rs-5144336/latest

I’ll start off strong by highlighting the wonderful work we are doing over here!