How do you move from static DNA models to real-time mechanics?
Join our next webinar to see how the team of Dr. Xiaolan Zhao at MSKCC uses the LUMICKS C-Trap to decode the molecular determinants of Smc5/6 association with DNA junctions.
🔗 web.lumicks.com/l/970813/202...
Last call! 🔔 Would you like to be considered for a poster presentation or a short talk during the SMBio 2026 Sheffield?
Today's the last day to sign up! Join the biggest UK gathering of this type yet: www.lumicks.com/event/sympos...
Huge congrats to Poul Martin Bendix (University of Copenhagen) for their feature on Biophysics Society TV at #BPS2026! 🎉 We're proud that the C-Trap helped power multiple research projects in the lab: from cell biology & medicine to nanoscience & plant science!
www.youtube.com/watch?v=TcZV...
Congratulations 👏
Wed 10:30 AM, B120: Ritika Gupta @finzi-dunlap-lab.bsky.social: ParBs condensates generate force for bacterial chromosome segregation.
Wed 10:30 AM, B116: Longfu Xu @ucblaborcenter.bsky.social: Correlated dynamics and activity mapping reveals rapid DNA polymerase exchange at the Replication Fork.
Ramesh Adakkattil of the Von Appen lab @mpi-cbg.de shares insights into the protein-DNA surface hydrogel that protecting the genome, Tue 1:45, B120.
Sneha Bhat @ucmerced.bsky.social: Single-Molecule Studies Reveal DNA Sensor IFI16B Inhibits AAIM2 Inflammasome via DNA competition, Tue 1:45, B144
Sergei Rudnizky @nucleosomezky.bsky.social: "Dynamic CTCF conformations control cohesin barrier function", Mon 1:45 PM, B177
Peter Murray: "Light-Activated CRISPR for On-Demand Perturbations of Chromatin Insulators", Mon 1:45 PM, B173.
Both of @bostonchildrens.bsky.social & @harvardmed.bsky.social
Jia Gao @pennstatechemistry.bsky.social on NAP1 and histone acetylation in regulation phase-separation of nucleosome arrays. Missed the poster? Check out the talk on Tue 12:30 PM, 207/208.
Tomoko Sunami @qst-japan.bsky.social on the polynucleosome during molecular crowding, Mon 1:45 PM, B166.
(2/2) At #bps2026, the valuable science isn't just presented on the main stage, it's on the poster boards. If you're walking the poster halls, stop by the boards of these incredible scientists to see C-Trap data in the context of important applications and ask them directly about their experience!
Read: Measuring the strength of catch bonds (performed on m/C-Trap) helped develop this new technique to elucidate the critical interaction sites leading to TCR activation & applicable to other mechanosensory receptors too. 👏 Congrats Bo Sun and Xiang Zhao among others! www.cell.com/cell/abstrac...
🎉 Congratulations to the teams of @arnegennerich.bsky.social and @floberger.bsky.social among others, for publishing their fascinating work on dyneins: www.nature.com/articles/s41...
"Dynamic CTCF Conformations Control Cohesin Barrier Function" - Sergei Rudnizky (Harvard Medical School) on Wednesday Feb 25, 1:30 PM - Room 201/202/203. Platform: Genome Organization and Dynamics.
And on Wed 25 Feb, 1:30 PM in Room 201/202/203, find Sergei Rudnizky (@nucleosomezky.bsky.social) on "Dynamic CTCF conformations control cohesin barrier function"
The best part of #BPS2026 is seeing the science our customers are producing in such variety. Next, we'll highlight the posters!
Both Tuesday, February 24: Jia Gao on "ROLES OF HISTONE CHAPERONE NAP1 AND HISTONE ACETYLATION IN REGULATING PHASE-SEPARATION OF NUCLEOSOME ARRAYS", 12:30 PM, Room 207/208. Raya Sorkin on "MEMBRANE TENSION AND ASYMMETRY AFFECT FUSION, AND INFORM VIRAL FUSION MECHANISMS", 09:05 PM, Room 209/210/211.
Jia Gao (@pennstatechemistry.bsky.social) on the roles of NAP1 and histone acetylation in regulation phase-separation of nucleosome arrays, 12:30 PM, 207/208.
Raya Sorkin (@sorkinlab.bsky.social) on how membrane tension and asymmetry affect fusion and viral fusion mechanisms, 09:05 PM, 209/210/211.
Tuesday 24 February in Room 207/208: 10:00 AM, Longfu Xu (@ucberkeleyofficial.bsky.social): correlated dynamics and activity mapping reveals rapid DNA polymerase exchange and SSB. Platform: Protein-Nucleic Acid Interaction II 10:05 AM, Ritika Gupta (Clemson University): ParBs condensates generate force for bacterial chromosome segregation. Platform: Protein-Nucleic Acid Interaction II
Tue 24 Feb, in Room 207/208:
10:00 AM, Longfu Xu (@ucberkeleyofficial.bsky.social): correlated dynamics and activity mapping reveals rapid DNA polymerase exchange and SSB.
10:05 AM, Ritika Gupta (@finzi-dunlap-lab.bsky.social): ParBs condensates generate force for bacterial chromosome segregation.
COMBINING FLUORESCENCE MICROSCOPY WITH OPTICAL TWEEZERS TO SHINE LIGHT ON DNA AND CHROMOSOMES. Erwin Peterman. Vrije Universiteit Amsterdam. Saturday 21 February 2026 - 4:00 PM - Room 303/304, Biological Fluorescence Symposium. A PROTEIN-DNA SURFACE HYDROGEL MECHANICALLY REINFORCES THE CELL NUCLEUS AND PROTECTS THE GENOME. Ramesh Adakkattil. MPI-CBG (Von Appen lab). Sunday 22 February 2026 - 4:00 PM - Room 201/202/203, Platform: Condensates from Biophysics to Disease I.
Find Erwin Peterman (@vuamsterdam.bsky.social) speaking on the virtues of combining fluorescence microscopy with optical tweezers on Saturday 4:00 PM, Room 303/304.
On Sunday, 4:00 PM, Room 201/202/203, Ramesh Adakkattil of the Von Appen lab (@mpi-cbg.de) speaks on the protein-DNA surface hydrogel.
User Spotlight: Where you can find C-Trap data at #BPS2026?
Browse through the thread to see the schedule of C-Trap customer's talks you don't want to miss, and save this post for later to revisit during the conference.
And come say hi to LUMICKS at booth 619 from Sunday to Tuesday!
Abstract deadline for the SMBio26 organized with the University of Sheffield, is postponed to February 27th to accommodate for extra spots made available!
To accommodate for extra spots made available, we're reopening the abstract deadline for the SMBio26 organized together with the University of Sheffield!
Organized with the @sheffielduni.bsky.social team: Matt Newton, @alicepyne.bsky.social & Ruby Peters.
Program & registration 👉 bit.ly/3NtxZlM
Solid tumors use a "sugar shield" (glycocalyx) to block immune cells. How do we break through?
Join our webinar to see how researchers from Harvard Medical School engineered "glyco-bridge" to enhance tumor recognition and killing, and validated by Cell Avidity measurements.
bit.ly/4rlQF5C
Please let us remind you it's the last day before the 1st abstract deadline of the single-molecule biology symposium SMBio26 in Sheffield, May 20th-21st. Don't be late!
Single molecules. Joint research.
www.lumicks.com/event/sympos...
One of the challenges in single-molecule biophysics is keeping your fluorophores stable long enough to capture the full story.
That's why we have partnered with Lumidyne to offer their specialized dyes.
Use code “LUMICKS” to enjoy 10% discount on all Lumidyne fluorephores. See info: bit.ly/463pZhQ
We are dedicated to making sure every LUMICKS user has the tools they need to succeed. That’s why we created LUMICKS University, your free, all-in-one gateway to mastering single-molecule experiments.
Join the 63% of C-Trap users who are already there:
www.lumicks.com/documentatio...
🎉This discovery provides the missing structural context for understanding cancer. Many mutations found in patients with hereditary breast and ovarian cancer map exactly to the spots where these proteins touch the DNA or each other.
Congrats to the team at The Francis Crick Institute!
🏗️
- The RAD51B Complex is the "Builder." It actively loads RAD51 bricks onto the DNA, building the repair filament.
- The XRCC3 Complex is the "Cap." The XRCC3 complex binds to the exposed 5’ end of the RAD51 filament and locks it in place. This was the study's structural breakthrough.
🔬Unlocking this secret required a combination of structural biology (Cryo-EM) and cutting-edge single-molecule technology (C-Trap). Using the C-Trap, the researchers observed a striking functional insight in real-time that traditional bulk assays missed:
🧬We were taught that the RAD51 paralogs, proteins essential in DNA repair and for preventing breast and ovarian cancers, work as a builder (BCDX2) and a helper (CX3).
This Science study from the lab of @westlabcrick.bsky.social and Simon Boulton has revealed a new machine: the XRCC3 Complex.
We thought we knew how DNA repair worked. We were wrong.
See the new publication from @science.org shifts the paradigm: www.science.org/doi/10.1126/...
See comment for our digest:
2nd Flyer includes names & titles of the SMBio26 Sheffield selected speakers
Organized with the @sheffielduni.bsky.social team: Matt Newton, @alicepyne.bsky.social & Ruby Peters.
👏 Speakers include Gijs Wuite, @jwelburn.bsky.social, @slfort.bsky.social, @akellett.bsky.social, @michellepeckham.bsky.social & Aakash Basu.
Program & registration --> bit.ly/3NtxZlM
Flyer: join us this year May 20 - 21, 2026 in Sheffield, UK, for the SMBio26 in Sheffield. Abstract deadlines for talks or posters is January 31st.
Jan 31 is the abstract deadline for SMBio26 Sheffield. Join us again this year for the 3rd single-molecule research symposium in the UK!
Present your research alongside some of the most inspiring scientists in the field.
Some spots are still available!
Program & registration --> bit.ly/3NtxZlM
Text over a Christmas tree detail
May your science shine bright this time of year, and the next✨.
Happy holidays to the #singlemolecule community here on Bluesky, from everyone at LUMICKS.
Published in Cancer Cell🎉 researchers in Upenn finds high Cell Avidity unlocked superior solid tumor killing.
Targeting KRAS, team of Dr. Daniel Powell showed that strong and stable cell-cell interaction is critical for therapeutic function in the solid tumor context.
www.cell.com/cancer-cell/...
