🚨New paper out @pnas.org!
Do you want to know how do mitotic motors organize the spindle? Wei Xiang's simulations show that just a plus & a minus motor are enough to drive bipolar spindle assembly. Could this explain why kinesin-5 & dynein evolved their unique properties? 🤔
doi.org/10.1073/pnas...
that's hot!
We're on a roll!🚀
Check our latest research @naturecomms.bsky.social: rdcu.be/ecXzr
We reveal how mosaic MTs faithfully mimic the GTP cap, highlighting lattice expansion (not pf twist) as the structural cornerstone of MT stability and dynamic instability.
Congrats to Juan and everybody involved! 🎉
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
NuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends. New study from Sabina Colombo, Thomas Surrey @surreylab.bsky.social and colleagues @crg.eu: https://buff.ly/41aj9F9
The Stonewall Inn and The Stonewall Inn Gives Back Initiative are outraged and appalled by the recent removal of the word 'transgender' from the Stonewall National Monument page on the National Park Service website. This blatant act of erasure not only distorts the truth of our history, but it also dishonors the immense contributions of transgender individuals - especially transgender women of color - who were at the forefront of the Stonewall Riots and the broader fight for LGBTQ+ rights. SIGBI followed by a next arrow
The Stonewall Inn and The Stonewall Inn Gives Back Initiative are outraged and appalled by the recent removal of the word 'transgender' from the Stonewall National Monument page on the National Park Service website. This blatant act of erasure not only distorts the truth of our history, but it also dishonors the immense contributions of transgender individuals - especially transgender women of color - who were at the forefront of the Stonewall Riots and the broader fight for LGBTQ+ rights. SIGBI followed by a next arrow
The Stonewall Inn and The Stonewall Inn Gives Back Initiative are outraged and appalled by the recent removal of the word 'transgender' from the Stonewall National Monument page on the National Park Service website. This blatant act of erasure not only distorts the truth of our history, but it also dishonors the immense contributions of transgender individuals - especially transgender women of color - who were at the forefront of the Stonewall Riots and the broader fight for LGBTQ+ rights. SIGBI followed by a next arrow
The Stonewall Inn and The Stonewall Inn Gives Back Initiative are outraged and appalled by the recent removal of the word 'transgender' from the Stonewall National Monument page on the National Park Service website. This blatant act of erasure not only distorts the truth of our history, but it also dishonors the immense contributions of transgender individuals - especially transgender women of color - who were at the forefront of the Stonewall Riots and the broader fight for LGBTQ+ rights. SIGBI
The Stonewall Inn released a response to the National Parks Service removing the word transgender from the park outside of the Inn. A great reminder that we have to look after each other
Mechanics of Single Cytoskeletal Filaments - Annual Reviews just out from @romet-jegou-lab.bsky.social @cecileleduc.bsky.social @hugowioland.bsky.social:
www.annualreviews.org/content/jour...
Solving 25 years of frustration, Daniel Abbühl managed to tag trypanosome tubulin and to express it in an inducible manner, hence revealing flagellum assembly! A tour-de-force!
Preprint here:
www.biorxiv.org/content/10.1...
NuMA (green) also protects minus ends after uncapping/treadmilling by KIF2A/spastin. Really interested to see what happens structurally at these minus ends
Microtubule minus ends are dynein/dynactin cargo via direct interaction with NuMA!
So thrilled to share my first paper as a first author. In these in vitro reconstitutions we observe how purified #spindle #proteins interact with #microtubules using #TIRF #microscopy 🔬👩🏻🔬
Grateful to those magic brains of the @surreylab.bsky.social for all the support along the way! 🫂
Change your life! Physiology course application deadline is extended to February 3rd! Apply now for a summer of discovery at MBL!
The FDA has scrubbed from its website guidance on conducting medical trials with representative numbers of men/women and racial/ethnic minorities. these aren't symbolic issues. Drugs affect men/men, people with different genetic backgrounds differently. talkingpointsmemo.com/edblog/medic...
Well, besides it being a bad day for everyone
if this is paywalled for you like it is for me this link will work for 50 days thanks #elsevier authors.elsevier.com/a/1kTSe3QW8S...
It's a good day (like every day) to be a tubulinologist, congrats on the nice work!
We got to write a dispatch on @askennard.bsky.social 's cool new paper on the evolution of tubulins and their interactomes, using Naegleria gruberi as a model.
Centromere evolution isn't a sudden switch!
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
fml
wtf less than 24 hours on the new twitter and my cyberbullies already on my case
stocowstic optical reconstruction
imaging some important biology @ EMBL imaging centre
📰 For a quick summary, read our website article: www.mpiib-berlin.mpg.de/2176621/news...
How did microtubules adapt to support life across 🐸 species at divergent thermal niches?
Now online & OA @currentbiology.bsky.social
Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL
🙌
Enjoy reading! 👉 www.cell.com/current-biol...
