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Blaise Mariner, PhD

@blaisemariner

blaisemariner.com Postdoc with http://smack-lab.com | PhD with https://labmccormick.org

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27.11.2023
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Latest posts by Blaise Mariner, PhD @blaisemariner

2026 Leadville 100 MTB {{MetaTags.description}}

I’m riding the Leadville 100 MTB this year and raising money for First Descents, which provides outdoor experiences for young adults impacted by cancer.
If you’re able, please consider supporting it; it's a great cause!
support.firstdescents.org/BlaiseMariner

09.02.2026 15:51 👍 0 🔁 0 💬 0 📌 0

Interested in metabolomics/systems biology and aging in Drosophila? We have a post-doc opening! And of course, there will be plenty of opportunities for side projects on the @dogagingproject.bsky.social. 🐶
promislowlab.org/wp-content/u...

16.12.2025 13:15 👍 9 🔁 10 💬 0 📌 0

Great to see drugs I studied during my PhD are extending lifespan in mice!

doi.org/10.1007/s113...

My PhD advisor Dr McCormick has made great progress understanding the basic biology that these drugs impact, mostly unpublished, but it’s well on its way!
For now:
doi.org/10.1007/s113...

13.11.2025 21:34 👍 1 🔁 0 💬 0 📌 0

Asking for qPCR confirmation of RNA-seq is worse than asking an engineer to re-measure a laser scan with a tape measure

30.10.2025 15:54 👍 1 🔁 0 💬 0 📌 0

Many autosomal genes are expressed from only one allele or show consistent bias toward one.

How cells establish and maintain these allele-specific patterns remains a mystery — yet this choice may be a key determinant of lifespan or disease

Check it:
Mariner et al. doi.org/10.1101/2025.10.14.682127

27.10.2025 16:31 👍 0 🔁 0 💬 0 📌 0

There are a lot of aging studies, especially recently, about the mutation accumulation hypothesis. Hydra wants to contribute to the discussion, too.

Hydra has mammal-like mutation rates facilitating fast adaptation despite its nonaging phenotype. doi: 10.1101/gr.279025.124

15.10.2025 19:42 👍 2 🔁 1 💬 0 📌 0
Preview
Genomics pioneer George Church earns first retraction for anti-aging gene therapy paper George Church A paper coauthored by geneticist George Church has been retracted following an internal review at a university where several coauthors are based. The article appeared in the Proceedin…

Genomics pioneer George Church earns first retraction for anti-aging gene therapy paper

@averyorrall.bsky.social reports

13.08.2025 21:22 👍 25 🔁 6 💬 2 📌 5
📣 Meet Our Speaker: Dr. Noah Snyder-Mackler
Get ready to be inspired at the AGE Annual Meeting 2025 by Dr. Noah Snyder-Mackler, Associate Professor in the School of Life Sciences at Arizona State University and Core Faculty in the Center for Evolution and Medicine.
Dr. Snyder-Mackler’s pioneering research bridges evolutionary biology, social behavior, and molecular medicine, focusing on how environmental and social factors—like social status, stress, early-life adversity, and natural disasters—influence gene expression, immune aging, and overall health trajectories.
Through in-depth studies of nonhuman primates and large-scale longitudinal research, he uncovers how our lived experiences are biologically embedded, impacting how we age and our risk for disease. His work is featured in leading journals such as Nature Communications, PNAS, and eLife, and continues to shape the future of aging and environmental health research.
📍 Don’t miss his session, “Environmental Modifiers of Molecular Aging Within and Across Individuals,” during our Primate and Translation track. Gain critical insights into how non-genetic factors drive molecular aging and longevity potential.
🗓️ Date: May 12, 2025
🕝 Time: 8:30 AM - 8:50 AM
📍 Location: Tikahtnu Ballroom, Dena’ina Civic and Convention Center, AnchorAGE, Alaska
🔗 Registration is open—join leading voices in aging research and secure your spot today:
https://bit.ly/4cJx8Gd
#AGEAnnualMeeting2025 #MeetOurSpeakers #NoahSnyderMackler #AgingResearch #EnvironmentalHealth #MolecularAging #Epigenetics #Geroscience #HealthyAging #PrimateScience #LongevityScience #ASU #EvolutionaryMedicine #ScientificLeadership #AnchorAGEAlaska

📣 Meet Our Speaker: Dr. Noah Snyder-Mackler Get ready to be inspired at the AGE Annual Meeting 2025 by Dr. Noah Snyder-Mackler, Associate Professor in the School of Life Sciences at Arizona State University and Core Faculty in the Center for Evolution and Medicine. Dr. Snyder-Mackler’s pioneering research bridges evolutionary biology, social behavior, and molecular medicine, focusing on how environmental and social factors—like social status, stress, early-life adversity, and natural disasters—influence gene expression, immune aging, and overall health trajectories. Through in-depth studies of nonhuman primates and large-scale longitudinal research, he uncovers how our lived experiences are biologically embedded, impacting how we age and our risk for disease. His work is featured in leading journals such as Nature Communications, PNAS, and eLife, and continues to shape the future of aging and environmental health research. 📍 Don’t miss his session, “Environmental Modifiers of Molecular Aging Within and Across Individuals,” during our Primate and Translation track. Gain critical insights into how non-genetic factors drive molecular aging and longevity potential. 🗓️ Date: May 12, 2025 🕝 Time: 8:30 AM - 8:50 AM 📍 Location: Tikahtnu Ballroom, Dena’ina Civic and Convention Center, AnchorAGE, Alaska 🔗 Registration is open—join leading voices in aging research and secure your spot today: https://bit.ly/4cJx8Gd #AGEAnnualMeeting2025 #MeetOurSpeakers #NoahSnyderMackler #AgingResearch #EnvironmentalHealth #MolecularAging #Epigenetics #Geroscience #HealthyAging #PrimateScience #LongevityScience #ASU #EvolutionaryMedicine #ScientificLeadership #AnchorAGEAlaska

📣 Meet Dr. Noah Snyder-Mackler, expert in how social & environmental factors shape molecular aging. Don’t miss his talk at #AGEAnnualMeeting2025: “Environmental Modifiers of Molecular Aging.” 🗓️ May 12 | 🕝 8:30 AM | 📍 AnchorAGE, AK
🔗 Register: bit.ly/4cJx8Gd

#Geroscience #HealthyAging #Epigenetics

23.04.2025 14:12 👍 1 🔁 1 💬 0 📌 0
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🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.

02.04.2025 11:28 👍 166 🔁 58 💬 7 📌 8

Just locked in my spot at AnchorAGE May 11 - 14 📅

Ready to dive into aging science and gather insights!

I hope to see you there!

11.03.2025 23:00 👍 1 🔁 0 💬 0 📌 0
Preview
WATCH LIVE: 'Stand up for Science' rally with Bill Nye and others at Lincoln Memorial in Washington YouTube video by PBS NewsHour

#StandUpForScience2025! Our greatest and most useful minds, get loud. If you support the opposition, it’s because you chose harming people over helping them. You’re either a part of the problem or a part of the solution. #science #Politics #activism #protest #DoNoHarm #scientificmethod #scientists

07.03.2025 18:19 👍 2 🔁 2 💬 0 📌 0

Prompt: "Explain _____ to me like I am 5 years old."

ChatGPT: "So, imagine you have a big box of crayons...."

LMAO

Well done, chat. Well done 👏👏👏

07.03.2025 18:41 👍 0 🔁 0 💬 0 📌 0
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Good papers lead to more questions than they answer. That's because (as Blaise Pascal wrote) knowledge is like a sphere: the larger it gets the larger also its surface, which is its interface with the unknown.

02.01.2025 23:23 👍 52 🔁 6 💬 1 📌 0
Tariffs, the Future of Cancer and Alzheimer's, Global Debt Cycles | Wall Street Week
Tariffs, the Future of Cancer and Alzheimer's, Global Debt Cycles | Wall Street Week YouTube video by Bloomberg Television

Thanks to Bloomberg TV Wall Street Week, David Westin, Sam Hornblower for a superb look at the troubling state of play in Alzheimer's research, featuring my new book "Doctored" and insights by Matthew Schrag and @elisabethbik.bsky.social at 10:30 on clip www.youtube.com/watch?v=DM4s...

08.02.2025 00:59 👍 7 🔁 3 💬 0 📌 1

Postdoc position available: Work with us at @mblscience.bsky.social on maternal age effects, #transgenerational inheritance, and #mitochondria. Cool project with a great model system. Postdoc salary at the MBL is well above the NIH pay scale!
#GeroSky #aging

recruiting.ultipro.com/MAR1033MBL/J...

06.12.2024 21:39 👍 6 🔁 6 💬 0 📌 0
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🌟 Join us in Anchorage, Alaska for the AGE 53rd Annual Meeting: New Frontiers in Aging Research! 🌟

This is an event you won’t want to miss!

📅 Save the Date & Be Part of the Conversation!

30.01.2025 19:26 👍 15 🔁 7 💬 0 📌 3
Preview
DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project Within a species, larger individuals often have shorter lives and higher rates of age-related disease. Despite this well-known link, we still know little about underlying age-related epigenetic differ...

Kicking-off my bluesky posts with a @dogagingproject.bsky.social preprint from my first year doing postdoctoral work at Arizona State! Onto peer-review!

www.biorxiv.org/content/10.1...

... and this is only the beginning! :D

#forksup ☀️ 😈 🔱

02.12.2024 13:58 👍 0 🔁 0 💬 0 📌 0