Transposable elements determine 3D genome organization—beyond CTCF binding
#TEsky
link.springer.com/article/10.1...
31.01.2026 06:45
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Transposable elements determine 3D genome organization—beyond CTCF binding
#TEsky
link.springer.com/article/10.1...
CytoTape in a neuron
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
🚨 Last chance to apply! 🚨Applications for the 2026 Summer Scholars Program close this Friday, 1/16.
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⏰ Final call! Applications for our #PhD program close December 1. Don’t miss your chance to train with world-class scientists in an independently fully funded program. #GradSchool
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Unfortunately my regular local coffee shop is closed on Mondays. Next time I'll skip the coffee if I can't go there! 😁
I said yeah that's what a decaf is with decaf beans made like a normal drink. He said "yeah we used to have decaf but for some reason they took it away."
For the record, this manager is the person the other girl asked if they had decaf beans. He acted like he didn't know what decaf was either.
I forced myself to complain with the idea that if she did that to someone who absolutely needed decaf they could be in trouble. So she gets the manager and he offered to give me my money back but asked "So you just wanted like a decaf shot?"
She knew how to make a coffee so plenty of people have ordered before, has no one really ever ordered decaf?!
Does she think that I'd be able to taste the absence of caffeine in this drink?
So now I'm sitting here with my decidedly regular coffee bean latte trying to decide if I should drink it.
I really wish my small local coffee shop that I love was open on Monday's.
I have questions.
Has she never heard of decaf before? This place has brewed decaf every day.
She continues "If it doesn't taste right, just come back up and we'll take care of it."
I don't have the energy to make a big deal of it and I'm not sure that I'd get anywhere with it even if I did.
When she finishes she calls my name and I say "Did you find the decaf beans?" She says "Yeah, I made it decaf but the beans might not be right" (she says this while looking at the grinder's hopper full of regular beans).
After a minute I hear her ask her coworked "he where are the decaf coffee beans?" He walks over and quietly says "we don't have any." There's some muttering for a couple seconds and he walks away. She goes on making the drink.
The worker at the store looked at me after I said decaf and asked "Decaf? So like no shots?" I said no, just with decaf coffee beans. She says "Oh I got you, OK." I pay. She says she'll start on it right away.
Several years ago I switched to drinking mostly decaf coffee. I still have a single cup of regular per day, but decaf is part of life now. I went to a coffee shop to do some work and I ordered a decaf carmel latte. This did not go according to plan...
My quote of the day
You build on failure. You use it as a stepping stone. Close the door on the past. You don't try to forget the mistakes, but you don't dwell on it. You don't let it have any of your energy, or any of your time, or any of your space.
Johnny Cash
I was at an arboretum recently and noticed a plant called globe amaranth (Gomphrena globosa) that seemed like it was likely fluorescent. Here's a paper showing its spectra www.cabidigitallibrary.org/doi/full/10....
This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social
Day 5
Prompt DEER
Pdb 4YXH
Two molecules of a deer prion protein decorate its head. Misfolded prions can make other prions to misfold causing neurodegenerative diseases in mammals.
Next: PIERCE
Suggestions?
I don't use AI on an everyday basis or nearly at all. I have been looking for a paper which I remember that showed expansion of bio samples so large that they are visible to the naked eye. I asked copilot and it found it immediately. It even gave me a real link that worked. I am devastated.
What makes #StowersGrad distinct from other #PhD programs? Our students are not limited to only learning under their PI. Experts throughout the Institute in our 16 Technology Centers offer additional learning opportunities.
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A new @sciam.bsky.social feature explores #research from the Halfmann Lab, revealing that our cells contain immune proteins that can instantly form crystals—triggering the cell to sacrifice itself when a virus invades. #SciSky
🔗 Read here: www.scientificamerican.com/article/cell...
I'm not sure. Perhaps Schrödinger's first name, so to speak.
![An image showing a salutation from an email I received that says "Dear Jeffrey," followed by "Dear [First Name],"](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:k6adddrypjqnb36x7yqw7wzz/bafkreibnhbdwwcoc7ovn2uhhpys6xohqei3xlxsjf3oamaxb4cltu7yn3i)
An image showing a salutation from an email I received that says "Dear Jeffrey," followed by "Dear [First Name],"
It's always funny to see these. The bar for effort on these type emails is so low. I believe in you, you can do it.
Has anyone tried using mesoscope.scripps.edu/beta/index.h... and CellPAINT2D to try to illustrate/simulate phase separation? You can make multivalent interactions, but they don't unbind, at least that I can figure out.
Thank you!
Beautiful movie! Can I ask how you restrained the embryo for this timelapse? Agarose? Or was it not necessary due to the stage?
This week is #CRC25 — our annual Crossroads Research Conference! A time for our community to connect, share discoveries, and spark new collaborations. Hear from attendees including @jeffjlange.bsky.social & @juliannahaug.bsky.social ⬇️
Applications for our #PhD program are NOW OPEN! Our independently fully funded program allows students to focus entirely on #research & growth, exploring their own questions while learning from top experts in the field. #GradSchool
Apply now: bit.ly/44VM6DI
Cnidarian-Microbe Interactions
Fully-funded postdoctoral position is available in the Gibson Lab at the Stowers Institute to investigate any aspect of cnidarian-microbe interactions. Strong background in coral symbiosis or eukaryotic microbiology preferred.
Contact Matt Gibson: mg2@stowers.org
