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Peiwei Chen

@peiwei-chen

HHMI Hanna Gray Fellow & Postdoc with Andy Clark and Cedric Feschotte at Cornell | selfish genetic element, transposon, small RNA, evolution peiweichen.com

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28.06.2024
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Latest posts by Peiwei Chen @peiwei-chen

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Introgression and parental conflict shape repeated occurrences of postzygotic isolation in Mimulus Postzygotic reproductive isolation is often thought to accumulate as a byproduct of neutral divergence. Yet it frequently evolves rapidly, in line wit…

I am SO THRILLED to share our first fully-lab lab paper!!!!!! Led by @hybridzones.bsky.social & @hagarsoliman.bsky.social, w/ a major assist from @pfschwarz.bsky.social!!!!!!!!!!!!! Read more below, if you're curious (you should be- it's AWESOME!!!!!!!)

link: www.sciencedirect.com/science/arti...

10.03.2026 15:44 πŸ‘ 157 πŸ” 61 πŸ’¬ 8 πŸ“Œ 3
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Marissa Scavuzzo β€” Pershing Square Philanthropies Pershing Square Philanthropies - we bet on innovative leaders solving humanity’s big societal, environmental, and health challenges.

Thrilled to share that the Scavuzzo lab was awarded the 2026 MIND prize to support our fundamental work in understanding how homeostasis is regulated by the gut’s nervous system! See more details here:

pershingsquarephilanthropies.org/prize-winner...

10.03.2026 15:12 πŸ‘ 16 πŸ” 3 πŸ’¬ 3 πŸ“Œ 0

#dros26 are you looking for a postdoc position and want to live in Paris?! Check out the opportunity below from @cecilecourret.bsky.social who has an exciting project on the Paris drive system in D. simulans 🀩

07.03.2026 14:42 πŸ‘ 5 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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So grateful to be able to share my work on the big stage during #Dros26! Thank you to everyone who attended my talk, especially to those who asked me such insightful questions!

06.03.2026 17:04 πŸ‘ 4 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Quick plug for our new resource, the Drosophila Species Stock Exchange. This is a database and mailing list that documents species currently in culture and the labs holding them. If you want to know more or sign up then please get in touch. See attached for more info and please share!

06.03.2026 19:59 πŸ‘ 44 πŸ” 48 πŸ’¬ 6 πŸ“Œ 1
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So good to see familiar faces at #dros26 😊 Ching-Ho @ching-hochang.bsky.social just opened his lab in Taiwan and Rebecca @tarnopol.bsky.social is opening her lab at UCSF this summerβ€”can’t wait to see what their labs do next!!! πŸ™Œ

07.03.2026 03:44 πŸ‘ 10 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The Nelson lab is presenting at #Dros26 today!

Stop by Daisy's poster to learn about rDNA instability in somatic aging (680F), and Caroline's poster about the role of an mRNA binding protein in regulating germline rDNA expansion (777F)!

06.03.2026 16:53 πŸ‘ 8 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

If you’re at #dros26 and you like transposons don’t miss Peiwei’s talk! πŸ”₯πŸͺ° We’re really excited about his findings!

06.03.2026 12:23 πŸ‘ 13 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0
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A lot of exciting things have been happing in the @rothenberglab.bsky.social so we have been keeping really busy. A few of us are at #Dros26 to share our science. Come by one of our posters to say hi!

05.03.2026 18:01 πŸ‘ 11 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0

If you are at #Dros26 and want to see what our lab has been up to, check out @rafaelperezvicente.bsky.social’s poster on sexual dimorphism during heart development (611, Fri 2-4pm) and @qeenyra.bsky.social’s talk on the effects of confinement on cardiac progenitor migration (Cell bio, Sat 8am). πŸ§ͺπŸͺ°

06.03.2026 03:14 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Tarnopol Lab

Now that the cat’s out of the bag: Excited to announce I will be starting a research group as a Sandler Fellow this August at UCSF! We will study the evolution of protein toxins at the host-pathogen interface across scales of biological organization. Learn more here:

www.tarnopollab.org

05.03.2026 20:23 πŸ‘ 20 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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Magnesium depletion by Candida albicans unleashes two unusual modes of colistin resistance in Pseudomonas aeruginosa with different fitness costs Bacterial resistance to the vital last-resort antibiotic colistin is an increasing challenge. This study shows that magnesium sequestration by C. albicans enables P. aeruginosa to evolve much higher l...

Our story on the evolution of colistin resistance is just out on @plosbiology.org (journals.plos.org/plosbiology/... Evolution doesn’t happen in isolation. We show that competing fungi can rewire the evolutionary trajectory of colistin resistance in P. aeruginosa. Great teamwork with the Ernst lab

05.03.2026 13:43 πŸ‘ 26 πŸ” 17 πŸ’¬ 2 πŸ“Œ 1
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Proud of Dr @tarnopol.bsky.social who received the Sandler Award for β€œOutstanding Drosophila Thesis” at the fly meeting #Dros26 in Chicago this evening! @genetics-gsa.bsky.social

05.03.2026 02:01 πŸ‘ 85 πŸ” 9 πŸ’¬ 7 πŸ“Œ 0
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Rebecca Tarnopol @tarnopol.bsky.social receives the 2026 Larry Sandler award for best Drosophila PhD thesis

05.03.2026 01:29 πŸ‘ 39 πŸ” 4 πŸ’¬ 1 πŸ“Œ 1

So excited to B repping the Hanlon Lab at #Dros26 in Chicago!!!

B-wildered by the B chromosomes? Come see my talk on the meiotic drive of the B chromosomes Friday morning in the Evolution I section!

05.03.2026 02:23 πŸ‘ 1 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
RNA-guided genome protection The genome carries information across generations, ensuring species survival. To preserve faithful transmission of genetic information, RNA-directed mechanisms safeguard the genome integrity in diver…

Join us at the EMBO Workshop β€œRNA-guided genome protection” πŸ‡¨πŸ‡­ June 16–20. Transposon silencing β€’ stem cell biology β€’ RNA-guided immunity. Keynotes: DΓ©borah Bourc’his + Ian MacRae. Register now + submit your abstract! meetings.embo.org/event/26-gen...

04.03.2026 15:42 πŸ‘ 12 πŸ” 11 πŸ’¬ 0 πŸ“Œ 0

What happens if the germline goes on without (most of the) piRNAs for 45 generations?

Come find out at my talk at the evolution session on Saturday at #dros26 @genetics-gsa.bsky.social

πŸͺ°πŸ”¬πŸ”Žβ‰οΈπŸ€”

04.03.2026 14:45 πŸ‘ 35 πŸ” 10 πŸ’¬ 1 πŸ“Œ 1
Annual Drosophila Research Conference 2026
Friday, March 6
8 to 10 PM
Workshop - Superior, Level 2
Everything You Ever Wanted to Know ...

Annual Drosophila Research Conference 2026 Friday, March 6 8 to 10 PM Workshop - Superior, Level 2 Everything You Ever Wanted to Know ...

#Dros26 community β€” we’d love to see you at our workshop this Friday! [1/8]

Organizers: @ritamgraze.bsky.social @marbeitman.bsky.social @lydiagrmai.bsky.social @gavinrrice.bsky.social @brhopkins92.bsky.social Artyom Kopp

03.03.2026 16:27 πŸ‘ 16 πŸ” 11 πŸ’¬ 1 πŸ“Œ 0
MBE | The evolutionary genomics of meiotic drive

Meiotic drivers gain transmission advantages by distorting equal, Mendelian segregation. This review discusses the evolutionary genomics of meiotic drive. The figure highlights the interactions of meiotic drive elements with other classes of selfish genetic elements including: direct interactions between drivers and transposable elements (TEs) (A) or satellites (C) that can facilitate the spread of drivers; other drive systems that cause the mutual destruction of all gametes (B; e.g. the presence of multiple toxin-antidote systems); indirect interactions where the host machinery responsible for silencing TEs are recruited to silence drivers (D); dosage-sensitive interactions involving sex-linked drivers that result in gene amplifications (E); and tradeoffs between suppressing drive and TEs (F).

MBE | The evolutionary genomics of meiotic drive Meiotic drivers gain transmission advantages by distorting equal, Mendelian segregation. This review discusses the evolutionary genomics of meiotic drive. The figure highlights the interactions of meiotic drive elements with other classes of selfish genetic elements including: direct interactions between drivers and transposable elements (TEs) (A) or satellites (C) that can facilitate the spread of drivers; other drive systems that cause the mutual destruction of all gametes (B; e.g. the presence of multiple toxin-antidote systems); indirect interactions where the host machinery responsible for silencing TEs are recruited to silence drivers (D); dosage-sensitive interactions involving sex-linked drivers that result in gene amplifications (E); and tradeoffs between suppressing drive and TEs (F).

For a new MBE Review, Presgraves et al. argue that many features of genome evolution, content, and organization seemingly inexplicable by adaptation or nearly neutral processes are instead best accounted for by meiotic drive.

πŸ”— academic.oup.com/mbe/article/...

#evobio #molbio

02.03.2026 09:30 πŸ‘ 22 πŸ” 13 πŸ’¬ 1 πŸ“Œ 0
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Decoding the molecular logic of rapidly evolving ZAD zinc finger proteins in Drosophila Identification of ZAD-ZnF genes as key regulators of genome organization during Drosophila embryogenesis.

Diving into evolutionary biology! What is the origin of the most abundant class of insect transcription factors, ZAD-ZnFs? We suggest that they evolved from ancestral insulator-binding proteins that control 3D genome topology.

www.science.org/doi/10.1126/...

27.02.2026 19:51 πŸ‘ 33 πŸ” 15 πŸ’¬ 0 πŸ“Œ 0
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Is a β€˜selfish gene’ making a Utah family have twice as many boys as girls? Genealogy study claims first conclusive case of sex β€˜distortion’ in humans β€” but not all researchers are convinced.

Nature News on the tantalising possibility of the first documented sex-ratio distorter in humans.
www.nature.com/articles/d41...

27.02.2026 13:53 πŸ‘ 11 πŸ” 6 πŸ’¬ 1 πŸ“Œ 1

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila.

Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and
@buszczaklab.bsky.social!

www.biorxiv.org/content/10.6...

23.02.2026 01:43 πŸ‘ 74 πŸ” 38 πŸ’¬ 4 πŸ“Œ 2

Adaptive evolution of Topoisomerase II triggers reproductive isolation in Drosophila https://www.biorxiv.org/content/10.64898/2026.02.20.707007v1

22.02.2026 01:33 πŸ‘ 12 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0

Yay!!! πŸ™Œ πŸŽ‰

22.02.2026 01:21 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Very honored to receive this award from GSA! I have immense gratitude for my advisor @nkwhiteman.bsky.social, labmates, collaborators, mentees, and the fly community, who in many ways potentiated my graduate research.

Looking forward to sharing my work at my favorite meeting in my favorite city!

20.02.2026 22:10 πŸ‘ 46 πŸ” 4 πŸ’¬ 8 πŸ“Œ 1
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Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related β€˜proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

β€œAncient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

18.02.2026 16:03 πŸ‘ 228 πŸ” 115 πŸ’¬ 8 πŸ“Œ 10
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We’re excited to announce @tarnopol.bsky.social as the recipient of the 2026 Larry Sandler Award! πŸŽ‰ She’ll present the Larry Sandler Memorial Lecture during the #Dros26 opening session on March 4β€”she'll share how her research explores how protein toxins evolve to shape host–parasite interactions.

19.02.2026 17:01 πŸ‘ 24 πŸ” 10 πŸ’¬ 1 πŸ“Œ 1
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πŸ”¬ Recruiting a Postdoc!!!!
I’m looking for a motivated postdoc to join my lab and work on characterizing the role of a heterochromatin protein involved in a sex-ratio meiotic drive system in Drosophila.
If you know someone who might be interested, please share widely!

19.02.2026 17:21 πŸ‘ 14 πŸ” 15 πŸ’¬ 0 πŸ“Œ 1
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my first termite queen extracted from a mature colony in the field 🀩
thanks @tatsuyainagaki.bsky.social

17.02.2026 19:37 πŸ‘ 11 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

How does the piRNA pathway solve the self vs. non-self problem? 🧬

Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

13.02.2026 15:11 πŸ‘ 90 πŸ” 51 πŸ’¬ 2 πŸ“Œ 4