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Flavio Donato

@flaviodonato82

Interested in all things memory, space, and the infant brain. @FensKavliNet Scholar. Assistant Professor @biozentrum @unibasel_en. Donatolab.com πŸ§ πŸ‘¨πŸ»β€πŸ”¬πŸ³οΈβ€πŸŒˆ

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21.10.2023
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Latest posts by Flavio Donato @flaviodonato82

Is spatial navigation innate 🧠? Using #NeuroPixels we show that the #torus 🍩 underlying the #GridCell map exists already on day 10 in rats β€” before pups open eyes and ears and before they start upright walking. 🧡1:4
πŸ‘‡
www.biorxiv.org/content/10.6...

11.03.2026 10:34 πŸ‘ 77 πŸ” 21 πŸ’¬ 1 πŸ“Œ 5

So exciting to see this out!! Congrats Matteo and whole team for this heroic effort! Can’t wait to read!!

11.03.2026 12:04 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Our new preprint is out!

A state-dependent neural circuit resolves approach–avoidance conflicts

www.biorxiv.org/content/10.6...

Fantastic work led by Devika Bodas, with key contributions from Marine Balcou, and a great collaboration with Lisa Scheunemann Lab, fearuting Şevval Demirci.

13.02.2026 14:29 πŸ‘ 47 πŸ” 19 πŸ’¬ 1 πŸ“Œ 2
Attention-like regulation of theta sweeps in the brain's spatial navigation circuit Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion β€” without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

The hippocampal map has its own attentional control signal!
Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See πŸ“Ή in post 4/6 and preprint here πŸ‘‰
www.biorxiv.org/content/10.6...
🧡(1/6)

28.01.2026 10:03 πŸ‘ 183 πŸ” 62 πŸ’¬ 4 πŸ“Œ 10

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

10.01.2026 09:42 πŸ‘ 154 πŸ” 63 πŸ’¬ 23 πŸ“Œ 2

Thanks Matteo!

28.12.2025 12:30 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Axon initial segment dynamics during associative fear learning - Nature Neuroscience Benoit, Ganea et al. show that changes in axon initial segment (AIS) length in the prefrontal cortex of mice accompany fear learning and extinction, revealing AIS plasticity as a key feature of neuron...

New study on axon initial segment plasticity by ChloΓ© Benoit and Dan Ganea. Using a deep brain imaging approach, we find that AIS length changes dynamically during associative learning. Thank you to the wonderful team and collaborators who made this work possible. www.nature.com/articles/s41...

23.12.2025 10:12 πŸ‘ 44 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0

Check this amazing resource by @octoscience.bsky.social !! Can’t wait to try it out!!

23.12.2025 20:15 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Insular cortex predictions regulate glucose homeostasis Brain-body interactions are essential for physical and emotional homeostasis. The brain uses information from the external world to predict upcoming bodily changes. This process involves interoceptive...

lab preprint! Interopceptive predictions are central to many brain-body interactions theories, but it's unclear if/how they affect bodily physiology. We (fearless Einav Litvak et al) show that insular cortex predictions are essential for glucose homeostasis-THREAD.. www.biorxiv.org/content/10.6...

12.12.2025 13:15 πŸ‘ 78 πŸ” 30 πŸ’¬ 3 πŸ“Œ 2
Ivan Dokmanić, Flavio Donato, Claudia Keller Valsecchi, Bence Gyârgy

Ivan Dokmanić, Flavio Donato, Claudia Keller Valsecchi, Bence Gyârgy

From artificial intelligence to memory and from gene regulation to treatments for blindness: four projects at the University of Basel will each receive around EUR 2 million over a five-year period to pave the way for new discoveries.

πŸ‘‰ www.unibas.ch/en/News-Even...

10.12.2025 08:48 πŸ‘ 21 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

Thank you!

11.12.2025 09:25 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks so much Ben!!

11.12.2025 09:25 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks so much Antonio!!

11.12.2025 09:25 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks so much Adrien!!

11.12.2025 09:25 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks so much Lukas!

11.12.2025 09:25 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks Julian!

11.12.2025 09:24 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks so much Sarah!

11.12.2025 09:24 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks Abraham!!

11.12.2025 09:24 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks so much Liset!!

11.12.2025 09:24 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks Jo!!

11.12.2025 09:24 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks Joaquin!

11.12.2025 09:23 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

This achievement belongs to every past and present member of the lab: you make the most ambitious projects feel possible and fill every day with excitement. Couldn't do this without you! 🧠✨ Looking forward to see what's next!!

09.12.2025 15:46 πŸ‘ 6 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Incredibly excited to share that we've been awarded an ERC Consolidator Grant to reach new depths in our memory research! @erc.europa.eu #ERCCoG @biozentrum.unibas.ch @unibas.ch

09.12.2025 15:46 πŸ‘ 68 πŸ” 1 πŸ’¬ 13 πŸ“Œ 1
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Happy to announce the 2nd Hippocampus Green Meeting
πŸ“ Barcelona, Spain
πŸ—“οΈ May 11–12, 2026
Organized together with Manu Valero, Lisa Roux and Dan Bendor
🎀 Keynotes: Nachum Ulanovsky & Gyârgy BuzsÑki
‼️ Call for abstracts now open
πŸ”— hippocampusgreen.net/wp/
#HippocampusGreen

07.12.2025 11:51 πŸ‘ 29 πŸ” 14 πŸ’¬ 0 πŸ“Œ 1
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Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy In this paper, we argue that Predictive Processing cannot be a unifying account of cognition until it can explain infant development. We show why development is crucial for understanding human cognit...

YES! "to explain all human cognition, we inherently must include development".
Beyond the Adult Mind: A Developmental Framework for Predictive Processing in Infancy - Ward - Topics in Cognitive Science - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....

02.11.2025 11:54 πŸ‘ 45 πŸ” 11 πŸ’¬ 1 πŸ“Œ 2

Beautiful work - congrats!

22.10.2025 20:09 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Functional independence of entorhinal grid cell modules enables remapping in hippocampal place cells A systems-level understanding of cortical computation requires insight into how neural codes are transformed across distinct brain circuits. In the mammalian cortex, one of the few systems where such ...

1/5 How does the brain turn the low-dimensional, universal grid cell metric into the rich, diverse codes needed for memory in hippocampal place cells? 🧡
Preprint link πŸ‘‡

www.biorxiv.org/content/10.1...

25.09.2025 04:06 πŸ‘ 72 πŸ” 16 πŸ’¬ 1 πŸ“Œ 5
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Looking forward to the #FRM25 @fens.org in Oslo! Excited to talk about the multi-laned hippocampus alongside @flaviodonato82.bsky.social and David Dupret. Great science and discussions ahead!

17.06.2025 07:14 πŸ‘ 11 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Super proud PI moment today when my first PhD student Vilde Kveim received the Shepherd price for her PhD work at today’s Biozentrum symposium. So lucky to have started my lab with you, Vilde!! @biozentrum.unibas.ch @biozentrum-phd.bsky.social

12.06.2025 18:46 πŸ‘ 29 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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On Friday, June 6, we will welcome Carlos Ribeiro @ribeirocarlitos.bsky.social @champalimaudr.bsky.social as the next speaker in our #BiozentrumDiscoverySeminar series. He will talk on "The Metabolic Mosaic: Illuminating the Interplay of Diet, Microbiome, Brain, and Metabolism"

03.06.2025 06:58 πŸ‘ 11 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0