PhageExe

Antagonism between bacteriophages and macrophages decreases efficacy of a bacteriophage cocktail and increases bacteriophage resistance Phage therapy, the use of viruses that infect bacteria (bacteriophages), is a promising complement to antibiotics during the antimicrobial resistance crisis, but treatment success is very variable. Ev...

How do macrophages influence the evolution of phage resistance?

We show that macrophages reduce the efficacy of a bacteriophage cocktail 🦠, resulting in greater bacteria population densities which, in-turn, facilitate greater rates of phage resistance.

Pre-print 👇
www.biorxiv.org/content/10.1...

At long last, the MHRA have released their much promised guidance document for phage therapeutics in the UK: assets.publishing.service.gov.uk/media/683ed3...

Early impression is it's either as hard as it was to access phage therapeutics, or they've closed the door on the one route we did have.

Eliminating the type I restriction endonuclease from Pseudomonas aeruginosa PAO1 for optimised phage isolation Phage therapy is a promising treatment for multidrug-resistant bacterial infections. Due to their high host specificity, phages must be matched to the target clinical strains. Efficiently identifying ...

If you want to improve promiscuity and yield of Pseudomonas aeruginosa for production of phages, start by taking out its restriction modification system: www.biorxiv.org/content/10.1...

Stable coexistence and transport of lytic phage infections with migrating bacterial hosts Bacteriophages (phages), viruses that exclusively infect bacterial hosts, are the most abundant living entities across diverse environments, coexisting with their bacterial hosts at densities exceedin...

Remy Chait's super-cool paper on phage lasers is now up on Biorxiv. A beautiful collaboration between modelling and experimental work, driven by passionate curiosity about unusual features Remy observed on some spot assays.
www.biorxiv.org/content/10.1...

Frontiers | Programming CRISPRi to control the lifecycle of bacteriophage T7

Using CRISPRi to non-invasively manipulate and probe the lifecycle and infectivity of T7. Very cool work from @bergmillerlab.bsky.social . T7 is a tough cookie to control! www.frontiersin.org/journals/mic...

Amazing few days with collaborators at Mowi and PhD student @mrliambh.bsky.social understanding where phage therapeutics could have the greatest impact in salmon farming in Scotland.

Critically evaluating the relative importance of phage in shaping microbial community composition The ubiquity of bacteriophages (phages) and the major evolutionary and ecological impacts they can have on their microbial hosts has resulted in phages often cited as key drivers shaping microbial com...

Hello new phage phollowers!

I am shamelessly self-promoting mine and Angus Buckling's relatively new review "Critically evaluating the relative importance of phage in shaping microbial community composition"

www.cell.com/trends/micro...

On a day where the National Audit Office reported that the government was not doing enough to combat the threat of untreatable bacterial infections (www.theguardian.com/society/2025...), we met with legislators to highlight the power of phage therapy to provide new treatments to patients.

Early Christmas present! @mathewmclaren.bsky.social @willstuart.bsky.social @daumlab.bsky.social