Intensive Care Medicine Experimental (ICMx)

⭐ ICMx 2025 Recap #VisualAbstract

Haemoadsorption to remove inflammatory mediators in sepsis: past, present, and future

doi.org/10.1186/s40635-025-00740-0

⭐ ICMx 2025 Recap #VisualAbstract

Early sepsis recognition: a pilot study using a rapid high-multiplex host-response mRNA diagnostic test

doi.org/10.1186/s40635-025-00735-x

⭐ ICMx 2025 Recap #VisualAbstract

Machine learning-based identification of efficient and restrictive physiological subphenotypes in acute respiratory distress syndrome

doi.org/10.1186/s40635-025-00737-9

Happy New Year from ICMx! 🥂

Wishing you health, peace, and a year of scientific excellence in 2026. We are excited to continue sharing the latest experimental medicine insights with you.

👉 Join our growing community on Bluesky: @icmexperimental.bsky.social

⭐ ICMx 2025 Recap #VisualAbstract

Wearable devices for patient monitoring in the intensive care unit

doi.org/10.1186/s40635-025-00738-8

⭐ ICMx 2025 Recap #VisualAbstract

Unlocking opportunities to transform patient care: an expert insight on limitations and opportunities in patient monitoring

doi.org/10.1186/s40635-025-00733-z

⭐ ICMx 2025 Recap #VisualAbstract

Patient–ventilator synchrony under non-invasive ventilation is improved by an automated real time waveform analysis algorithm: a bench study

doi.org/10.1186/s40635-025-00726-y

⭐ ICMx 2025 Recap #VisualAbstract

Renal mitochondria response to sepsis: a sequential biopsy evaluation of experimental porcine model

doi.org/10.1186/s40635-025-00732-0

⭐ ICMx 2025 Recap #VisualAbstract

Using weak signals to predict spontaneous breathing trial success: a machine learning approach

doi.org/10.1186/s40635-025-00724-0

⭐ ICMx 2025 Recap #VisualAbstract

Regional cerebral oxygen saturation during initial mobilization of critically ill patients is associated with clinical outcomes: a prospective observational study

doi.org/10.1186/s40635-025-00722-2

⭐ ICMx 2025 Recap #VisualAbstract

From the best-of-the-year collection: a standout ICMx 2025 Visual Abstract you don’t want to miss.

Exploring timely and safe discharge from ICU: a comparative study of machine learning predictions and clinical practices

🔗 doi.org/10.1186/s40635-025-00717-z

⭐ ICMx 2025 Recap #VisualAbstract

Kicking off our ICMx 2025 Year-in-Review!

Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review

🔗 doi.org/10.1186/s40635-024-00710-y

Unravelling the complex inflammatory landscape of COVID-19 infection
Delirium in COVID-19 ARDS associates with unique cytokine signatures and altered B/T-cell subsets.
🔗 doi.org/10.1186/s40635-025-00825-w
#MedSky #FOAMed #ICU #Covid19 #ImmunoSky

Mitochondrial oxygen tension drops in acute sepsis and correlates with severity, yet recovers by follow-up, supporting reversible metabolic dysfunction rather than persistent failure.
🔗 doi.org/10.1186/s40635-025-00808-x
#MedSky #FOAMed #ICU #Sepsis #ImmunoSky

Hepatic and intestinal microcirculation and pulmonary inflammation in VV ECMO in rats
Microcirculatory injury varied with ECMO flow: gut hypoxia emerged only at low-flow, liver impairment at both. Lung inflammation fell across ECMO groups under protective MV.
🔗 doi.org/10.1186/s40635-025-00824-x

Low-bicarbonate substitution and CO₂ removal in combined ECCO₂R-CRRT
A lower bicarbonate load may optimize ECCO₂R-CRRT performance, enhancing VCO₂ at low flows without compromising patient stability, suggesting a modifiable dialysate target.
👉 doi.org/10.1186/s40635-025-00827-8
#MedSky#ICU #ARDS

Recovering mice restored NKA with more activating NKRs and cytotoxic subsets, while lethal sepsis showed persistent NK suppression.
🔗 doi.org/10.1186/s40635-025-00829-6
#MedSky #FOAMed #ImmunoSky #Sepsis #ICU

🩸 Knowledge gaps in extracorporeal blood purification
From cytokine adsorption to pathogen removal, EBP faces major mechanistic and clinical uncertainties. Precision phenotyping and real-time immune monitoring may unlock its potential.
🔗 doi.org/10.1186/s40635-025-00819-8
#MedSky #ICU #Sepsis

REVIEW 🌊 Venous congestion from a vascular waterfall perspective
Venous waterfalls, organ-specific Pcrit, and why kidneys suffer while liver/intestine partly buffer pressure. Implications for PEEP, fluids, and Doppler assessment.
🔗 doi.org/10.1186/s40635-025-00828-7

Fluid removal improves muscle performance and weakness in critically ill patients
Ultrafiltration during CRRT reduced muscle and tissue edema on US and was linked to improved strength scores within 36 h, suggesting fluid balance may influence muscle quality. 🔗 doi.org/10.1186/s40635-025-00830-z

Impaired serum neutralization and death in Omicron-infected critically ill patients: insights from the French SEVARVIR study
Early strategies boosting neutralization may be key.
🔗 doi.org/10.1186/s40635-025-00831-y
#MedSky #FOAMed #PulmSky #PulmCrit #IDSky #ImmunoSky

💪 MUScleNut study
Muscle ultrasound revealed marked early SM decline in critical illness; nutritional risk predicted greater loss, underscoring the need for optimized strategies.
📎 doi.org/10.1186/s40635-025-00823-y
#MedSky #FOAMed #RadSky #EchoSky #EchoFirst #POCUS

How much #lung water is too much?🌊

This study demonstrates that CT-based estimates of EVLW in COVID-19 patients correlate well with TPTD values—suggesting a non-invasive, cost-effective alternative for #ICU monitoring.

🔗 doi.org/10.1186/s40635-025-00752-w
#MedSky

Can steroids reshape post-arrest metabolism?

High-dose methylprednisolone after OHCA alters plasma metabolites for 48 h—lowering ω-6 fatty acids and boosting tryptophan, arginine, and C3. A metabolic shift with therapeutic potential?

🔗 doi.org/10.1186/s40635-025-00754-8

#MedSky #CardioSky

In a new ICU mouse model, age and sex drive divergent responses to LPS-induced lung injury. Old males benefit most from ventilation, but old females fare worst. A step forward for translational critical care research.

🔗 doi.org/10.1186/s40635-025-00756-6

#MedSky #PulmSky #PulmCrit #IDSky

Mixed reality in the ICU? 👓

The ArtekMed system blends AR/VR for teleconsultation—rated promising by most users but still lags behind standard video calls in usability.

Real-time virtual care is coming…

🔗 doi.org/10.1186/s40635-025-00758-4

#MedSky

Can we control fever in acute brain injury without compromising brain oxygen? 🧠🌡️

Extended diclofenac infusions reduce temperature—but slightly lower PtO₂ too.

What does this mean for neurocritical care?

🔗 doi.org/10.1186/s40635-025-00759-3

#MedSky #NeuroSky

38th Annual Congress - Munich - ESICM The 38th Annual Congress, "LIVES," will take place in Munich from October 25-29, 2025, at the International Congress Centre Munich (ICM).

📢 Call for #Abstracts

#LIVES2025, the 38th Annual Congress of the @esicm.bsky.social , invites you to submit your original contributions in #IntensiveCare.

✨ Accepted abstracts will be published in a Supplement of #ICMx!

🗓️ Deadline: 10 April 2025, 23:59 CET

🔗

Awards - ESICM The ESICM Research Awards provide funding for innovative research projects in intensive care medicine across various disciplines.

🔬 The ESICM #Research Awards recognize groundbreaking projects that advance the field of #IntensiveCare.

🔹 Showcase your expertise
🔹 Gain recognition within the #ICU community
🔹 Contribute to the progress of #CriticalCare

📅 Deadline: 10 April, 23:59 CEST

www.esicm.org/research/awa...

#MedSky

📢 New Visual Abstract!

The effects of urine alkalinization on kidney function in critically ill patients with COVID-19: a proof-of-concept randomized clinical trial.

🔗 doi.org/10.1186/s40635-025-00739-7

#MedSky #ICMxVisualAbstract #FOAMcc #NephSky #Nephpearls