Anastasia Baryshnikova

Three years ago, we showed ~70% of lifespan variation in yeast traces to rDNA copy number. Ribosomal DNA, encoded as 5S and 45S subunits in hundreds of copies, vary substantially across humans. Does this copy number variation, and sequence variation within these paralogs, matter for humans?

We are integrated into the growing global Computational Innovation unit with colleagues sharing deep expertise in data management, computational biology, AI/ML and other synergistic areas of interest.

Shares and reposts are very welcome. Please also reach out to me directly if you have questions.

It's a unique opportunity to:
- Work with an exceptional range of biobanks, many with exclusive access.
- Collaborate with world-class therapeutic domain experts & contribute to new treatments across many disease areas.
- Directly impact short- and long-term portfolio strategy & decision making.

Our Human Genetics team @boehringerglobal.bsky.social (Biberach site, Germany) is actively searching for an experienced Statistical Geneticist.

#StatisticalGenetics #HumanGenetics #BoehringerIngelheim #ComputationalInnovation #JobOpportunity

lnkd.in/g6QPihVE

Interactions with polygenic background impact quantitative traits in the UK Biobank Association studies have linked many genetic variants to a variety of phenotypes but under-standing the biological mechanisms underlying these signals remains a major challenge. Since genes operate wi...

Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank!

A thread... 🧵

www.medrxiv.org/content/10.1...

Regeneron buys 23andMe out of bankruptcy Drugmaker’s takeover comes less than two months after start-up filed for protection

Regeneron buys 23andMe out of bankruptcy

https://www.ft.com/content/362bcad4-8f4a-42b4-ab86-38821d74352f

Genetic suppression interactions are highly conserved across genetically diverse yeast isolates Sometimes the detrimental effects of a mutation can be rescued by another mutation. For genetic diseases, such suppressor mutations may identify new therap

The latest work of PhD student Claire Paltenghi
@fbm-unil.bsky.social @unil.bsky.social @umasschan.bsky.social, on the conservation of genetic suppression interactions across genetic contexts, now published in G3 @genetics-gsa.bsky.social: doi.org/10.1093/g3jo...

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful.

It’s available on Amazon: tinyurl.com/mx2hewen

Thank you!

A huge thanks to our new collaborators who helped bring this story across the finish line – Katie Cardone, @rachitk.bsky.social, @marylynritchie.bsky.social, and @ksusztak.bsky.social.

Our updated APOL1 manuscript just went live on #bioRxiv – perfectly timed with #APOL1AwarenessDay (April 29). We've sharpened our hypothesis and focused the supporting evidence for a clearer story.

#APOL1 #KidneyResearch #UKBiobank #pQTL

www.biorxiv.org/content/10.1...

Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model Phenotypic variation arises from the interplay between genetic and environmental factors. However, disentangling these interactions for complex traits remains challenging in observational cohorts such...

New pre-print klaxon: "Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model" led by the excellent Bettina Welz + @saulpierotti.bsky.social from @wittbrodtlab.bsky.social, Felix Loosli, Kiyoshi Naruse and my own lab www.biorxiv.org/content/10.1...

Postdocs: Human Genetics at Utah will be hosting our annual Rising Stars in Genetics and Genomics Symposium in Sept. Apply here: shorturl.at/wBMg2
There will be sessions on developmental, evolutionary and disease genetics. A chance be invited to SLC to network here and with peers! Please share.

An under-appreciated perk of AI-aided coding: the consistent positive encouragement you rarely get IRL! Just finished a co-coding session with ChatGPT and it signed off with "Good luck with your project -- it's shaping up beautifully 🙌". Needed that!

#AICoding #DeveloperLife #ChatGPT

Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out!
meetings.cshl.edu/courses.aspx...

Platform-dependent effects of genetic variants on plasma APOL1 and their implications for kidney disease Mutations in apolipoprotein L1 (APOL1) are strongly associated with an increased risk of kidney disease in individuals of African ancestry, yet the underlying mechanisms remain largely unknown. Plasma...

New preprint! Our latest work on plasma proteomics in UKBB helps unraveling the fascinating connection between APOL1, parasite resistance, and kidney disease.

www.biorxiv.org/content/10.1...

#APOL1 #KidneyDisease #Plasma #Proteomics #Genetics #Biomarkers #KallikreinKinin #AfricanAncestry #UKBB