Laboratory of Molecular physiology and adaptation

The methyltransferase activity of Dot1L is essential for Xenopus tropicalis tadpole development and survival - Cell & Bioscience Epigenetic modifications of histones play key roles in transcriptional regulation by diverse transcription factors. One such modification is the methylation of histone H3 at lysine 79 (H3K79). The met...

link.springer.com/article/10.1...

🧬🐸 In a new study, Emeric Louis and colleagues show that DOT1L-dependent H3K79 methylation is essential for Xenopus tropicalis tadpole development and survival. Loss of this epigenetic mark causes developmental delay and early lethality. #Epigenetics #DevelopmentalBiology

Molecular and genetic studies on the signaling and the regulation of amphibian metamorphosis by thyroid hormone, the contribution of Jamshed Tata and Donald Brown Post-embryonic development refers to the process by which embryonic development has been completed and the organism reaches maturation. Amphibian meta…

www.sciencedirect.com/science/arti...

🧬🐸 Amphibian metamorphosis helped reveal how hormones control gene expression. Our review by Salomé Nashed revisits the groundbreaking contributions of Jamshed Tata and Donald Brown, who established this model as key to understanding thyroid hormone action. #DevelopmentalBiology #Endocrinology

Read the article: DOI: 10.1016/j.ydbio.2026.02.001
#Research #DevelopmentalBiology #MNHN #Endocrinology #Xenopus

Our lab just published a study on the crosstalk between corticosterone and triiodothyronine (T₃) during limb bud development in Xenopus tropicalis. We reveal how these hormones interact to regulate hundreds of genes, with major implications for bone formation and environmental stress adaptation.

La plateforme de biologie moléculaire du Muséum national d'Histoire naturelle recrute un ingénieur.
Envie de travailler dans un environnement stimulant et un cadre exceptionnel, n'hésitez pas à candidater.
Offre réservée aux agents CNRS
@cnrsbiologie.bsky.social @cnrsecologie.bsky.social @mnhn.fr

Effects of thyroid disruption on neural cells stem fate in the mouse brain Thyroid hormones (THs), particularly T3 and T4, play crucial roles in neural development and maintenance by regulating neural stem cell (NSC) prolifer…

www.sciencedirect.com/science/arti...

New review by Valcarcel-Hernandez & colleagues reveals how thyroid disruption (e.g. via PFAS) can skew neural-stem-cell fate in the mouse brain — reducing neurogenesis and impairing myelin repair. This raises concern for brain development & repair in polluted environments. #endocrineDisruption #PFAS

Characterization and expression of urotensin1 and urotensin2 genes in the caudal neurosecretory system of the small-spotted catshark Scyliorhinus canicula The caudal neurosecretory system (CNSS) is a neuroendocrine complex unique to fish. In teleosts, the neuroendocrine neurons of the CNSS, called Dahlgr…

www.sciencedirect.com/science/arti...

New work from the lab. Cartilaginous fishes hold ancient secrets of neuroendocrine evolution. In our new study, Bérénice Bichon and col. show that urotensin genes (uts1a, uts1b, uts2) shape two distinct Dahlgren-cell populations in the catshark CNSS #evolution #neurobiology

Pleiotropic function of Dlx5/6 in the development of mammalian vocal and auditory organs Acoustic communication, a cornerstone of social interactions in mammals, relies on both vocal (effector) and auditory (receptor) organs, which display remarkable morphological diversity across species...

doi.org/10.1371/jour...

New work from the lab. Evolution may have used the same genetic toolkit to shape how mammals make sounds and how they perceive them. In our new study, Frida Sánchez-Garrido and colleagues show that Dlx5/6 guide the development of both vocal and auditory structures. #evolution #developmentalbiology

Au sein des poissons, certains téléostéens et les cyclostomes présentent, à un ou plusieurs moments de leur cycle biologique, des changements drastiques de leurs morphologie, physiologie et comportement.

Découvrez en plus dans cette revue :

www.biologie-journal.org/articles/jbi...

IA générative : le risque de l’atrophie cognitive IA générative : le risque de l’atrophie cognitive - Une Tribune à découvrir sur Polytechnique Insights

Une interview fascinante de Ioan Roxin,
professeur émérite à l’université Marie et Louis Pasteur, sur les risques cognitifs liés à l'utilisation de l'IA.
www.polytechnique-insights.com/tribunes/neu...

We are all so proud of you ! 🙂

L’axolotl, un animal beaucoup trop mignon pour disparaître ? Sur les billets, dans Minecraft, TikTok ou Pokémon, l’axolotl est partout. Mais dans les canaux de Xochimilco, au Mexique, le petit amphibien sauvage lutte pour sa survie

L'axolotl, une des espèces élevées au laboratoire est en danger dans la nature. Notre directeur Laurent Sachs nous en dit plus :
www.20minutes.fr/planete/anim...

Impact of acute environmental challenges on the expression of peptide hormone-encoding genes in the zebrafish caudal neurosecretory system The caudal neurosecretory system (CNSS) is a neuroendocrine complex unique to fish, first described in 1955. Since then, it has been hypothesized to c…

New work from the lab. Bérénice Bichon and Guillaume Pézeron describe the impact of acute environmental challenges on the expression of peptide hormone-encoding genes in the zebrafish caudal neurosecretory system.
www.sciencedirect.com/science/arti...

La transcriptomique spatiale

Le Pr Marie-Stéphanie Clerget-Froidevaux, co-responsable de l’équipe BBC, organise le 4 avril 2025 un webinaire technique dédié à la transcriptomique spatiale, sous l’égide de la Société de Neuroendocrinologie
Plus d'info : phyma.mnhn.fr/fr/agenda/la...

Poste de technicien(ne) pour un CDD de 1 an

Notre unité souhaite recruter un(e) technicien(ne) en CDD pour une durée de 1 an. La personne recrutée sera affectée à la plateforme d’édition du génome chez les amphibiens. Renseignements et contacts : phyma.mnhn.fr/fr/actualite...

The regulatory landscape of 5′ UTRs in translational control during zebrafish embryogenesis Reimão-Pinto et al. introduce thousands of different mRNA reporters into zebrafish embryos to investigate the contribution of 5′ UTR features to translation initiation during embryogenesis. The work d...

Fascinating work : The regulatory landscape of 5′ UTRs in translational control during zebrafish embryogenesis: Developmental Cell www.cell.com/developmenta...

La pollution aux PFAS plonge la Flandre dans un désastre dystopique A l’ouest d’Anvers, se trouve l’un des pires « hot spots » de l’empoisonnement de l’environnement par les « polluants éternels ». La zone fait aujourd’hui figure de laboratoire de décontamination pour...

Formidable et bouleversant reportage du @lemonde.fr sur le drame de la pollution aux PFAS.
www.lemonde.fr/les-decodeur...

About our lab lab. Did you know that the Physiology Laboratory in the Muséum was in fact the first French Physiology laboratory. It was founded in 1837 by Fréderic Cuvier (brother of George, the famous geologist and paleontologist).

The Phyma lab is now on Bluesky ! 🦋

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