My last collaboration with F. Cougnon et al. just published in Chem! We introduce a class of polycationic receptors constructed from multiply entangled macrocycles and specifically engineered to recognize sulfate in aqueous solution. @dquimicauib.bsky.social www.sciencedirect.com/science/arti...

Multicomponent Oxicam–Metformin Salts: Toward a Strategy for Enhancing Solubility and Stability Drug–drug pharmaceutical multicomponent materials (PMMs) offer a promising strategy to modulate the physicochemical properties of active pharmaceutical ingredients, while enabling synergistic effects and combination therapy. Here, we report the preparation and full characterization of a new family of oxicam–metformin (MTF) salts, involving the nonsteroidal anti-inflammatory drugs piroxicam (PRX), meloxicam (MLX), and tenoxicam (TNX). Structural and computational studies revealed the role of supramolecular synthons in directing the salt formation and highlighted the relationship between molecular packing and physicochemical properties. Stability analyses showed that these materials enhance MTF stability, while particularly protecting PRX from hydration. Importantly, incorporation of MTF increased the aqueous solubility of the oxicams, while salt formation moderated the excessive solubility of free MTF. Significant modifications in fluorescence behavior were also observed, arising from interactions between functional groups involved in the fluorescence procedure within the frameworks. Overall, this study broadens the structural and functional landscape of oxicam–MTF salts and provides a rational framework for designing solid forms with improved stability and solubility.

New oxicam–metformin drug–drug salts enhance oxicam solubility up to 46× at physiological pH while stabilizing metformin. A crystal engineering strategy to tune pharmaceutical performance. 🔬💊

Great collaboration with @tonifrontera.bsky.social and A. Rodríguez-Diéguez

@iactcsic.bsky.social

🎉Happy International Women’s Day! This #IWD2026, we showcase the groundbreaking research led by women within the LUCESCOSTAction. From advancing supramolecular chemistry to developing next-gen sensors. Explore their work and publications here: lucescostaction.com/publications

Alizarin red S@ZIF-8 composite-modified carbon paste electrode: A novel sensitive sensor for the voltammetric determination of asenapine maleate in human plasma - Microchimica Acta Microchimica Acta - The development of a novel, highly sensitive electrochemical sensor for ASP based on an alizarin red S-functionalized zeolitic imidazolate framework-8 (ALZ@ZIF-8) nanocomposite....

👏👏Great collaboration with Prof. Noha M. Hosny (Assiut University, Egypt) on the utilization of alizarin red and ZIF-8 composite-modified carbon paste electrode. A new sensor for the determination of asenapine in Human Plasma! 👇@dquimicauib.bsky.social @uib.cat
link.springer.com/article/10.1...

CrystEngComm outside front cover for vol 28, issue 1.

🔓The front cover of issue 1 features an #openaccess article by Francisco Javier Acebedo Martínez, @duanechl.bsky.social and co-workers - Seeking new polymorphs in pharmaceutical cocrystals: focus on furosemide-ethenzamide. Read it here ⬇️🧪

🔗 doi.org/10.1039/D5CE...
📍 @iactcsic.bsky.social

Multicomponent Oxicam–Metformin Salts: Toward a Strategy for Enhancing Solubility and Stability Drug–drug pharmaceutical multicomponent materials (PMMs) offer a promising strategy to modulate the physicochemical properties of active pharmaceutical ingredients, while enabling synergistic effects ...

📣Excellent collaboration with @duanechl.bsky.social and his group on drug−drug pharmaceutical multicomponent materials just published in @acs.org Cryst. Growth & Des. Enhancing solubility and stability of oxicam-metformin salts!
@uib.cat @dquimicauib.bsky.social pubs.acs.org/doi/full/10....

With the aim to stimulate collaborations and the exchange of ideas, the LUCESCOST Action MC has decided to fund small meetings (workshop) where PIs and their researchers can discuss their ongoing research and plan further collaborations. @costprogramme.bsky.social 👇
lucescostaction.com/workshops2026

We celebrate the International Day of Women and Girls in Science by shining a light on the brilliant women managing the LUCES COST Action. From coordinating grants to leading scientific strategy, our female leaders are turning vision into impact every day. @costprogramme.bsky.social
#LUCES #IDWGIS

📢Yesterday, the LUCES COST Action Core Group gathered in Madrid for a meeting. Hosted by Prof. Paula Bosch at the ICTP-CSIC, the team came together to define the next steps for our network, including the next GAM in Athens. A thank you to Prof. Bosch and the ICTP team!🙏 @costprogramme.bsky.social

From fluorine chemistry to noncovalent interactions: celebrating Prof. Giuseppe Resnati Celebrating the remarkable mission of Professor Giuseppe Resnati in science.

🧪Now online: From fluorine chemistry to noncovalent interactions - a cross-journal collection in @pccp.rsc.org , @crystengcomm.rsc.org and NJC celebrating the 70th birthday of Prof. Giuseppe Resnati. doi.org/10.1039/D5CP...

📣📣Submit your photos 📷by 1pm (CET time) on Wednesday 11th February for a chance to win prizes. Stay tuned to our socials for the official announcement of the winners!!

#LUCES #WomeninSTEM #11Feb_COST_LUCES

📣Whether it’s running spectra, packing a column or collaborating with lab mates 👩‍🔬, we want to highlight you in celebration International Day of Women👩 and Girls👧 in STEM.

Don’t forget to tag LUCES COST Action and use #LUCES #WomeninSTEM #11Feb_COST_LUCES
@costprogramme.bsky.social

📣📣 In celebration of the International Day of Women 👩 and Girls 👧 in STEM, we’re launching a raffle with exciting prizes just for LUCES COST women!

Snap your Science!

#LUCES #WomeninSTEM #11Feb_COST_LUCES

Further info in the next posts 👇

CrystEngComm outside front cover for vol 28, issue 5.

🔓On the cover of issue 5 is #OpenAccess work of Ángel García-Raso, Juan J. Fiol, @tonifrontera.bsky.social & co investigating the crucial role of lattice water in directing supramolecular networks of deferiprone analogues. Read it here⬇️

pubs.rsc.org/en/content/a...

📍 @uib.cat 🧪

Terbium-enhanced poly(Pyrosin) sensor for the concurrent Electroanalysis of L-Dopa, carbidopa, and Istradefylline in human plasma The present work rationalizes the construction of a cutting-edge electrochemical sensor and its utilization in establishing the unique square wave vol…

📣Happy to see this paper out!. In Collaboration with Noha M. Hosna, we present the first electrochemical sensor for simultaneous analysis of three anti-Parkinson drugs: L-dopa (LVD), carbidopa (CRD), and istradefylline (ISF). @dquimicauib.bsky.social @uib.cat 👇
www.sciencedirect.com/science/arti...

👏Glad to see this paper out! In collaboration with P. Postnikov, G. Resnatti et al. we used cooperative Supramolecular Engineering (HB & XB) for the Enhancement of Exchange Interactions in Nitronyl Nitroxide Systems. @pubs.acs.org @dquimicauib.bsky.social @uib.cat pubs.acs.org/doi/full/10....

Great Collaboration with K. Rissanen and R. Puttreddy on Halogen Bonding in Halopyridine‐Cu(II) Complexes. What a comprehensive Solid‐State and Interaction Study with Human Serum Albumin. @chemistryeurope.bsky.social @dquimicauib.bsky.social
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Chemoselectivity in the cationic Phospha-Wittig reaction: accessing phosphorus heterocycles, phosphaalkenes, and their annulated [4 + 2] dimers Triflate salts of phosphito-phosphanides [LCP–P(OR)3]+ (1[OTf], R = alkyl, LC = N-heterocyclic carbene) were obtained via nucleophilic fragmentation of the tetraphosphetane [(LC)4P4][OTf]4 (3[OTf]4) w...

Our new work has now been published as #MyFirstChemSci @chemicalscience.rsc.org !
We demonstrate the first cationic Phospha-Wittig reaction and a new dimerisation mode for phosphaalkenes.
Thanks @tonifrontera.bsky.social for another wonderful collab.
Read more here:
pubs.rsc.org/en/content/a...

📢We are pleased to announce that registration is now open for the major event of our COST Action in 2026!
The third edition of LUCES annual meeting will take place April 20-21 in Athens. Please visit the event webpage for detailed information. lucescostaction.com/gam3 @costprogramme.bsky.social

A remarkable case of supramolecular Umpolung. Nice collaboration with M. Malischewski from @freieuniversitaet.bsky.social. The 4-Fold Protonation of Tetracyanometalates causes the formation of π-Hole Bonding in the Solid State. @acs.org @dquimicauib.bsky.social @uib.cat pubs.acs.org/doi/full/10....

📣Very nice Christmas present! Just published in @chemicalscience.rsc.org the result of a collaboration with J.J. Weigand in Dresden. we report the synthesis and mechanistic study of Cationic Phospha-Wittig reaction! 👇👏@dquimicauib.bsky.social @uib.cat
pubs.rsc.org/en/Content/A...

📣New work showing that cooperative σ/π-Hole donors as (perfluoroarene)2Ch (Ch = S, Se, Te) are relevant in crystal growth and supramolecular chemistry. Great collaboration with V. Yu. Kukushkin and colleagues. Just published in @acs.org @dquimicauib.bsky.social @uib.cat pubs.acs.org/doi/abs/10.1...

Proud to contribute to the special issue dedicated to the 70 anniversary of Prof. G. Resnati in Coord. Chem. Rev. In this review we highlight that Halogens can act as as noncovalent chemical chameleons (Electrophilic-nucleophilic dualism).
@uib.cat
@dquimicauib.bsky.social
doi.org/10.1016/j.cc...

The 3rd Edition of the International Supramolecular Chemistry Summer School is scheduled on May 24th-29th 2026!
Find all the infos for the registration at convegni.unica.it/iscsummersch... Hurry up, only 80 slots available!!
PLS share this message
@lucescostaction.bsky.social

The chalcogen atom Ch (O, S, Se or Te) replacement at element–Ch⋯nucleophile has a significant impact on the strength and directionality of chalcogen bonding.

Don't miss the collaborative Highlight review by Vânia André, Luísa M. D. R. S. Martins, @tonifrontera.bsky.social & Kamran Mahmudov & co: Effect of a single chalcogen atom variation on the chalcogen bond parameters: CSD analysis and theoretical calculations 👇

🔗 doi.org/10.1039/D5CE... 🧪

Electrophilicity of Anionic Iodide Ligands: Platinum(IV)-Induced Halogen Bond Donor Ability Halogen bonding (HaB) traditionally occurs between electrophilic halogen donors and nucleophilic acceptors, yet this study reveals a phenomenon wherein anionic iodide ligands demonstrate an electrophilic behavior in platinum(IV) complexes, directly contradicting their inherent nucleophilic nature. Crystallographic analysis of trans-[PtI4(CNCy)2], [PtI4(phen)]·I2, and trans-[PtI4(SMe2)2], combined with molecular electrostatic potential (ESP), quantum theory of atoms in molecules (QTAIM), natural bond orbital (NBO), and electron localization function (ELF) analyses, demonstrates that platinum(II) oxidation to platinum(IV) transforms coordinated iodides from HaB acceptors to HaB donors. This transformation occurs through positive σ-hole development at iodide ligands, with ESP values shifting from negative (−9.6 kcal/mol) in platinum(II) to positive (+1.9 kcal/mol) in platinum(IV) complexes. Energy decomposition analysis reveals that dispersion forces dominate these interactions rather than electrostatics, contrasting with classical σ-hole donors where electrostatic contributions typically prevail. Cambridge Structural Database analysis identifies 32 additional platinum(IV) structures exhibiting similar PtIV–I···Nu HaBs, demonstrating this phenomenon’s widespread nature. This study reveals new opportunities for controlling noncovalent interactions through metal oxidation state manipulation.

📣Did you know that the electrophilicity of anionic iodide ligands can be tuned? In particular, Pt(II) to Pt(IV) oxidation Induced Halogen Bond Donor Ability. More details in our recent publication in Inorganic Chemistry. @dquimicauib.bsky.social @uib.cat
pubs.acs.org/doi/full/10....

📣Very happy to share the result of my last collaboration with Fabien L. Cougnon just published in Nature Communications. We demonstrate that is is possible to program the assembly of multistranded helices in water. @dquimicauib.bsky.social @uib.cat 😀👇
www.nature.com/articles/s41...

Expanding the Structural Portfolio of Hydantoin Derivatives with Spiro Frameworks Bearing π-Functionalities The hydantoin ring is a key structural feature in many pharmaceutically active compounds and blockbuster drugs, especially those targeting disorders of the central nervous system. In an effort to expa...

Happy to share the result from my first collaboration with Nemanja Trišović from U. of Belgrade. In this work we have expanded the Structural Portfolio of Hydantoin Derivatives with Spiro Frameworks Bearing π-Functionalities. @dquimicauib.bsky.social Cryst. Growth Des.
pubs.acs.org/doi/full/10....

Very happy to share that our recent article with @duanechl.bsky.social published in @pubs.acs.org Crystal Growth & Design journal has been highlighted as most-read research. @dquimicauib.bsky.social

📣Nice collaboration with @conchitagimeno.bsky.social and her group just published in @inorgchemfront.rsc.org where we highlight how strategic ligand design can modulate photophysical responses, advancing the development of next-generation responsive luminescent materials.👇
doi.org/10.1039/D5QI...