Nabina Pun

We’re happy to be in Liverpool for this years @britsocimm.bsky.social congress:
In today’s “What’s hot in cancer immunology?” session, Prof David Withers presented our new data on an orthotopic colorectal cancer model for the first time! 🐭💪

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammatio…

Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬

www.sciencedirect.com/science/arti...

What a week! So pleased to now also see the peer reviewed version in Science Signaling of @megtriesscience.bsky.social PhD work joint with the Saunders lab, see her great thread for explanation below www.science.org/doi/10.1126/...

Thanks Elaine!!

This study was fantastically led by @NabinaPun98 working together with @UCytlak. Nabina did an amazing job leading the charge into a new area for our lab and is now at the start of what is going to be a truly fantastic career in research, watch this space for more to come!

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatme...

So pleased to share the peer reviewed first study from our @cruk-ci.bsky.social @mcrcnews.bsky.social Radnet collab led by @nabinapun.bsky.social and Dr Cytlak with Prof Travis and Prof Illidge @lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social www.mucosalimmunology.org/article/S193...

🙏 Huge thanks to all my co-authors and collaborators - this was a truly team effort!
Grateful for the support of the Dyer, Illidge and Travis lab and everyone in RadNet who helped make this project possible. @cruk-mi.bsky.social

#Immunology #Radiobiology #Monocytes #TissueRepair #Research #Science

💡 Big picture:
Immune cell recruitment isn’t always harmful.
Here, CCR2⁺ monocytes actually protect against injury by supporting IL-17 production and maintaining the intestinal barrier after radiation.

🔍 Why it matters:
Radiotherapy saves lives, but gut toxicity often limits how much treatment patients can tolerate.
By revealing how monocytes and ILC3s cooperate to protect intestinal tissue, we identify new therapeutic opportunities to reduce side effects and improve outcomes.

🧬 What we found:
Abdominal/pelvic radiotherapy can damage healthy intestinal tissue - a major challenge in cancer care.
We discovered a protective immune pathway:
CCR2 → monocyte recruitment → ILC3 → IL-17 → barrier protection

This axis helps the gut resist radiation-induced injury.

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatme...

Excited to share my PhD work (in @douglaspdyer.bsky.social’s lab) now published in Mucosal Immunology! 🥳
Our study explores how the immune system protects the gut during radiotherapy.
🔗 www.mucosalimmunology.org/article/S193...

In this weeks @oxcio.bsky.social seminar, our PostDoc Pascale presented her current progress on setting up #SingleCellSequencing experiments and their analysis for the @witherslab.bsky.social in Oxford! 🖥️💡🐭
Exciting!!!

Excited to share our latest review article, "Cellular Cosmetics: How Innate Lymphoid Cells Can Recontour the Tumour Microenvironment”!

This article aims to stimulate discussions on targeting these adaptable immune cells to enhance immunotherapy strategies.

It was so good to present my work in the withers lab for the first time!! 😎

🐣 We followed with our Junior PIs telling us about their questions for the next 5 years 💡 Lots of exciting, cutting-edge new ideas that will hopefully materialise soon and bring even more new questions to #CIO 🤓 🥳 #CIOawayday @galvez-cancino.bsky.social @mjwsim.bsky.social

✨ Kicking off #CIOawayday with our senior PIs sharing the experiments that changed their careers 🧑‍🔬👩‍🔬🧫 A reminder that serendipity, curiosity, and pub chats can spark groundbreaking ideas 🤓 Clearly science thrives on kindness and collaboration and we got a lot of that in #CIO 😉🙃 #ScienceLife

Today we’re at the @britsocimm.bsky.social Bristol Immunolgy Group presenting some of our recent data!

Lydia Becker Institute Profile - Iashia Mulholland - PhD student - Dyer Lab

#BeckerProfile @iashiamulholland.bsky.social

From taking a 12-year break after high school to raising a family & working in industry, to researching lung inflammation & the endothelial glycocalyx in the Dyer Lab - read about Iashia's journey into academia! 👇

sites.manchester.ac.uk/lydia-becker...

McClure, @hepworth-lab.bsky.social, Konkel et al. outline a Th17-to-Tfh plasticity during #periodontitis that is protective and limits periodontal pathology. https://buff.ly/41fwVq4

📘 In Host–Microbe Interactions 2025 👉 https://buff.ly/40XMv8r

After a great few weeks settling into my new lab with @jcstark.bsky.social at the @mitkochinstitute.bsky.social , I’m thrilled to share I have been awarded a TBBCF postdoc fellowship! This award will fund the next 2 years of my research targeting glycans for the treatment of breast cancer 🦠

So pleased to share the first study from out @cruk-mi.bsky.social led by Nabina Pun with Mark Travis, Tim Illidge and Urszula Cytlak www.biorxiv.org/content/10.1...

Had a great time co-authoring this new review with @hepworth-lab.bsky.social and Alanna Kelly!

Interested in what's going on in the niche microenvironments ILCs call home? Then check out the pre-proof version, online now at @mucosalimmunol.bsky.social !