Buck O’Flanagan

Frontiers | Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient

Check out the case report we wrote on a fascinating case of teratoma in the testes. This case illustrates that pure mature teratomas occurring in postpubertal males cannot invariably be classified into the benign teratoma category.

www.frontiersin.org/journals/onc...

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...

New: Lee et al. @harvardmed.bsky.social provide a compendium of early transcriptional responses to major inflammatory #cytokines across all major immunocyte lineages of the mouse, highlighting unappreciated relationships btwn these cytokines and with other cytokine families https://buff.ly/4gn71Fg

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

Today in @nature.com. We mapped the spatial and temporal dynamics of intestinal tissue-resident memory CD8 T (TRM) cell differentiation.
🔗 www.nature.com/articles/s41....
@ucsandiego.bsky.social @lji.org @alleninstitute.bsky.social @amonell.bsky.social @reinacampos.bsky.social @GoldrathLab 🧵 1/10

Building Cure at the Seattle Children's Research Institute

Super excited to announce that the Joag Lab will officially open at @UW, @SCRI in March 2025! We will study the interplay between memory T cells and stromal, humoral, and innate immunity in mucosal tissues. researcherprofiles.seattlechildrens.org/Vineet.Joag. Hiring a technician and a postdoc!

New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe

#MucosalImmunology #TumorImmunology

Excited to share my PhD work from Rafi Ahmed’s lab, now published in @nature.com. We show how CD8 T cells overcome the inability to predict how long a viral infection will last by making adaptable precursor cells a priori—an elegant strategy for a non-prescient immune system! tinyurl.com/53nrpsa6

TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8+ T cells
doi.org/10.1101/2025...

New: Papadopoulos, Kipnis and colleagues present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. https://buff.ly/40724ub

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

Elegant work by Jason Cyster's group

"Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky

Nutrient-driven histone code determines exhausted CD8+ T cell fates ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

The hypoimmune mouse (MHC-deletion, CD47 overexpression) and all of its organs are completely invisible to allogeneic immune cells
www.cell.com/iscience/ful...

The danger theory of immunity strikes back... rdcu.be/d1uQN

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity - Nature Aging Exploring how aging compromises antitumor immunity, the authors reveal an age-related impairment of cytotoxic CD8+ TRM cells in mouse tumor models and clinical samples. They implicate BFAR signaling a...

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity
www.nature.com/articles/s43...

Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!

Excited for my first bluesky post announcing TWO openings for tenure track positions in virology! I am chair of the search committee and with a new department head Mike Gale we are in an exciting building phase.

Please share with anyone who might be interested: hr.myu.umn.edu/jobs/ext/365...

We’ve jumped on board fully here on 🦋
A starter pack of those working on our favourite cell … the T cell 🥰🙈🥰

If you want an add let us know

go.bsky.app/8B5P25c

Would love to be added!

Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency Tissue-resident memory T (TRM) cells are integral to tissue immunity, persisting in diverse anatomical sites where they adhere to a common transcripti…

Retinoic acid and TGF-β – instructors at Trm university?
Interesting stuff from Obers, Evrard, Mackay & al., who delve into environmental cues driving tissue-specific fate decisions of #Trm.

Curious what other site-specific signals guide Trm differentiation in other tissues!

Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4+ T cell response This study characterizes the dendritic cells that present antigen to tumor-specific CD4+ T cells in the tumor and tumor-draining lymph node.

Last month in #ScienceImmunology, Alex Chudnovskiy,
@victora.bsky.social, & al. used proximity-based labeling in combination with single-cell transcriptomics to characterize antigen-presenting dendritic cells in tumors and their draining lymph nodes.

Hi Tobias! Would love to join! Thank you for putting this together

I made a starter pack for those of us interested in or working on T cells. Let me know if you would like to be added or know somebody that should be added.

Looking forward to scientific discussions and updates on our favorite immune cell type!

go.bsky.app/Eaua5Jk my starter for neuroimmunology

Ever wondered what T cell immunosurveillance of 🐭 mammary ducts looks like? Check out our image featured on the cover of Science Immunology, showing CD103+ (pink) antiviral memory T cells (cyan) w/ in the ductal epithelium 🤩

Hi Anna! Could you please add me, would love to join!

Highlights:
1. I.n. vaccination induces more lung Trm compared to I.m. vaccination
2. mRNA vaccination elicits Trm in the regional vaccine-draining LN
3. I.m. prime+boost + i.n. boost establishes robust circulating and lung resident memory T cells

Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells Intramuscular mRNA vaccination induces pulmonary resident memory T cells that can be further expanded with intranasal boosting.

How does route of mRNA vaccination impact localization and abundance of memory T cells? shorturl.at/foBMY.