David W. Sanders!

Beautiful work!

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...

I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.

Really impressive stuff. But I think cliff’s former grad student is bummed that you scooped him up on a good portion of his story. Suspected as much, so pulled back my investments from speckles when I started my lab to let yall lead. :)

Nuclear speckles enable processing of RNA from GC-rich isochores Nuclear speckles are key subnuclear structures that regulate gene expression in GC-rich regions. This work shows that the evolution and expansion of core speckle proteins were crucial for the increase...

The function of nuclear speckles is revealed! This is an incredibly important paper with absolutely beautiful data! Wow! www.cell.com/cell/fulltex...

goddamnit. even you are going into clinics to monitor that? I was planning on scheduling a looksy into my rectum using your custom scopes. to be clear, if that is a paid service you offer, im still game. dont trust no doctors to go deep up there.

not tmi, but it read as you having colon cancer. glad to hear this is not the case!

fuck: you okay? im always around to talk. please feel free to stop by and complain about your colon: we all have and hate them. most are damaged. mine is crinkled beyond all recognition. thinking about your health!

oops. didn't realize this made nature. nevermind. you are rightful that this is undeserving of nature as nothing deserves to be in nature. carry on with your....horizontal....science. ;)

Chefs kiss. Thanks for a laugh.

My dude. I never sign things I’ve read. Only those I haven’t.

Are nih debt collectors after me or not? I’m poor. A

@jeremymberg.bsky.social any idea?

What is this? I didn’t know that I needed to pay my training fellowship loans….

Full-justify grant apps or death!

Very nice Alex. You are one of the few people in the phase/idr field who are doing meaningful, rigorous work. Thank you! Thank you.

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...

More functional data, many thousands of words removed, and a few other updates from last year's preprint.

No shit, Sherlock. Its speed! Did Nico get free drugs again at least?

The Senate version of the NIH appropriations bill has language that limits the use of multiyear/upfront funding. Please call your Senators and Representatives to make sure it is in the final bill.

We must stop the brain drain in our research workforce before it's too late.

Thanks for the clarification and keep posting your critiques. Disagreement and debate make science stronger! It’s why I love academic science!

I do not personally enjoy arguments about jargon. Clusters, phases, networks, percolated fluids, granules, bodies. Whatever. I’m not a physicist. I just want to understand what these cool multicomponent droplet thingies do in living systems. Deciding who “owns” the “discovery” is a distraction.

Fine. True “Llps” is not a thing in biology. Pure physics don’t apply. You can quote me on this. Biology is complex. But biological liquids are real. The polyphasic linkage of these co-existing phases requires decades of study to understand fully. Whether awards are deserved is above my pay grade.

I dunno why this is a bridge to die on. I like you a lot. I like Cliff a lot. I am amenable to your criticisms of “the field”. I certainly think an opportunity for productive debate about terms/complexities was missed circa 2020. But your tone reads as personal. Cliff eg is not a snakeoil salesman.

Your thoughtful opinions have provided a useful counterpoint to “rah-rah dogma” in the phase separation field. My opinion: such discourse has inspired greater rigor and skepticism, which was urgently needed when you started your righteous debate. This post is beneath that. It reads as personal.

Texans Make History with Passage of Proposition 14, Launching Nation’s Largest State-Funded Dementia Research Initiative Texas voters approved funding the Dementia Prevention and Research Institute of Texas (DPRIT), the nation's largest state-funded dementia research initiative. OG image: press release

DPRIT passes! $3-billion Texas investment in dementia research: www.alz.org/news/2025/te...

(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.

StayRose: a photostable StayGold derivative red-shifted by genetic code expansion Photobleaching of fluorescent proteins often limits the acquisition of high-quality images in microscopy. StayGold, a novel dimeric green fluorescent protein recently monomerised through sequence engi...

mStayRose is published in JBC 🥳🎉

Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:

www.jbc.org/article/S002...

Ut southwestern is recruiting! 3-milly start-up for tenure-track or tenured PI positions in O’Donnell Brain institute. Basic and translational neuroscientists both. If I can call myself a neuroscientist, so can you! Please consider reposting :) #DPRITisComing apply.interfolio.com/174927

Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇