Shubharthi Kar

Figure 2. Primary endpoints (A) The least-squares mean proportion of patients with resolution of MASH without worsening of fibrosis after 24 weeks of treatment; error bars represent SE; MASH resolution was defined as at least a 2-point reduction in NAS (scale of 0 to 8, with higher scores indicating more severe disease), no hepatocyte ballooning, and a score of 0 or 1 in the lobular inflammation component of the score, without worsening fibrosis. (B) The least-squares mean proportion of patients with liver fibrosis improvement without worsening of MASH after 24 weeks of treatment, defined as the proportion of patients achieving at least a one-stage improvement in liver fibrosis without worsening of NAS; error bars represent SE. A composite strategy was employed that considered patients with missing outcomes due either to missing biopsies or treatment discontinuations as non-responders. Data were analysed with the use of the chi-square test. MASH=metabolic dysfunction-associated steatohepatitis. NAS=non-alcoholic fatty liver disease activity score.

Another G-force molecule
GLP + glucagon agonist #pemvidutide in MASH

Resolution of MASH, fibrosis impact not seen at this time

www.thelancet.com/journals/lan... in @thelancet.com

How long till someone (?Pfizer) gobbles up Altimmune? @rnflex.bsky.social

EDITORIAL: Breaking Down Barriers to Reproductive Health Care in CKD

bit.ly/48wkB7l (FREE)

Happy to share that our abstract has been accepted for upcoming #ISNWCN

Fish Oil in Dialysis: A Big Catch or an Empty Net — NephJC Holy Mackerel! This week we will discuss fish oil use in maintenance hemodialysis patients. Could this be the one thing that bends the curve on CV mortality, or is it just a red herring?

Maybe the most shocking study from #KidneyWk.
🐚From the depths of the oceans to #BlueSky, we're discussing PISCES 🐟 12/2/25 9pm EST. #NephJC
Are you hooked🪝on fish oil for CV disease in ESRD, or are you throwing it back 🌊?
www.nephjc.com/news/pisces-fishoil

My conference talk at the Kidney Foundation Dhaka, Bangladesh, concluded with an invitation to register for the upcoming WCN 2026, to be held from March 28–31 in Yokohama, Japan.

🐦‍⬛ Please note that the deadline for Early Bird Registration is January 24, 2026. #ISNWCN #ThisisISN

#Exome-wide Analysis Identifies a Rare #EXD3 Missense Variant Associated With #Diabetic #Kidney Disease

#VisualAbstract by Stephanie Torres

https://www.kireports.org/article/S2468-0249(25)00649-7/fulltext

Niina Sandholm

Attacking the Origin of IgAN: ORIGIN3 and Atacicept — NephJC This week, we will discuss the phase 3 ORIGIN3 trial of atacicept, an APRIL/BAFF inhibitor for use in IgAN.

The #NephJC summary and VA are live

www.nephjc.com/news/atacice...

Excellent fast work from @notjustdialysis.bsky.social and @salinesolut.bsky.social

Atacicept in IgAN

1a/🌞Hello everyone, welcome to the #WorldDiabetesDay #skeetorial on behalf of @theisn.org @who.int
⁉️Let us begin with a quiz
🎊Do you know the theme of World Diabetes Day 2025?
a/ Breaking barriers, bridging gaps
b/ Family and diabetes
c/ Access to diabetes care
d/ Diabetes across life stages

📣 Save the date!
🗓️ October 28, 12pm EST
Join us for a Space on Tropical AKI, Part 2
🎧 Set your reminder twitter.com/i/spaces/1gq...

🧠 Before the session, test your knowledge!
Take the quiz 👉 theisn.outgrow.us/Tropical_AKI
Let’s see how much you know about Tropical AKI before the experts dive in! 💪🌴

Protein supplementation in CKD: The Visual Abstract — NephJC We like protein, or do we? Low protein, high protein, supplements…what’s a nephrologist to do?

🎨Beautiful visual abstract by @msocomd.bsky.social #NephJC

Shubharthi from Bangladesh. No COI. #NephJC

Preeclampsia - FAQs Preeclampsia Treatment, Eclampsia, Eclampsia Treatment, Toxemia, PET and PIH, HELLP Syndrome, Causes Preeclampsia, Preeclampsia Affect Pregnancy, Preeclampsia Affect the Baby

September is #PCOSAwarenessMonth. Women who have polycystic ovary syndrome #PCOS have a risk of developing #preeclampsia in their #pregnancy.

Learn more here: www.preeclampsia.org/faqs

🎬 Share your story! Submit your short film for the 2026 #ISNFilmEvent — real stories from those affected by kidney disease and their care teams. Open to ISN members. Deadline: Nov 5 (midnight CET).
🎥 Info & submissions ➡️ http://lite.spr.ly/6... #ThisIsISN #ISNWCN

1/ July 16 is #WorldSnakeDay - raising awareness of the incredible diversity of snakes and their vital role in our ecosystems. But did you know snakebites can also cause acute kidney injury? Join me, Dr. Fong Voon Ken, as we discuss their impact, management, and the need for awareness.

𝗡𝗘𝗪 𝗥𝗘𝗦𝗢𝗨𝗥𝗖𝗘 𝗔𝗟𝗘𝗥𝗧: Download our #ADPKD infographic for a quick overview of diagnosis, delaying progression, complications & more. A handy resource for clinicians and patients alike!
⬇️https://www.theisn.org/wp-content/uploads/2025/07/ADPKD-Infographic.pdf

📢 The kidney community urges UN Member States to include kidney disease in the 2025 Political Declaration on NCDs & Mental Health.

🧬 850M affected
📈 5th leading cause of death by 2050
💡 Early care = 45% cost savings

📄 Read the letter: www.theisn.org/wp-co... #KidneyHealthMatters #HLM4 #NCDs

Visual abstract - still needs work since KI doesn’t get professionals to do it! 🤷🏽‍♂️

Interesting data from Alberta

www.kidney-international.org/article/S008... in @kidneyint.bsky.social

GFR < 15 is classified as ‘kidney failure’ in most studies - but about a third of them die before starting RRT.

Is that glass half full or half empty? 🥃

#NephSky

Introducing NephJC Shorts — NephJC In just over a decade of critical appraisal on NephJC, we have done several experiments. Some of them have worked out phenomenally well, such as the Freely Filtered podcast. Others were not ready for ...

We don’t get to discuss every important study that comes out on #NephJC

Hence #NephJCShorts

www.nephjc.com/news/nephjc-...

⚡️Let’s have a closer look at the associations of each of these antigens
#ECNeph
@arvindcanchi.bsky.social
indianjnephrol.org/an-updated-r...

Now that’s a roll! Thanks for joining tonight’s #ECNeph discussion
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social

⚡️PLA2R antibody seropositivity doesn’t mean that we do not investigate for underlying malignancies.
Here is a Case Report showing PLA2rAb MN having Carcinoma Oesophagus
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social

KDIGO recommends Population and Age-appropriate Screening for malignancies irrespective of antigen status
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social

KDIGO Approach When to Biopsy in MN patients
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social @rheaultm.bsky.social

3 approaches Contd
2. Panel approach: Alternatively, a laboratory could employ a standard panel of antibodies for antigens that can vary depending on volume and demographics
3. Proteomic approach: Laser microdissection of MN glomeruli, followed by mass spectrometry. #ECneph

3 approaches suggested by the Mayo clinic consensus report
1. Targeted approach: Perform antigen testing based on clinical disease association
Cont #ECNeph
www.kidney-international.org/article/S008...

Here’s a timeline of the auto-antigens found in MN
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
indianjnephrol.org/an-updated-r...

👉 🫣 Can IF differentiate from Primary and Secondary MN?
IgG 4 is the dominant class in primary MN
👉 IgG1,IgG2, IgG3 are dominant Immunoglobulins in Secondary MN

#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social

👉 MN is a pattern of glomerular injury
👉 Deposition of immune complex along subepithelial aspect of GBM
👉 On Light Microscopy GBM is thickened. GBM spikes or holes can be seen
👉 IHC/IF shows IgG with C3 along capillary wall
#ECNeph
@theisn.org @dramiliflores.bsky.social @arvindcanchi.bsky.social

If it is malignancy associated MN then no role of IS. Treatment of cancer is priority #ECneph