Pegah Poursharifi

Suppression of adipocyte ABHD6 favors anti-inflammatory and adipogenic programs to preserve adipose tissue fitness in obesity Some individuals exhibit metabolically healthy obesity, characterized by the expansion of white adipose tissue (WAT) without associated complications.…

Here the Prentki lab proposes that inhibition of monoacylglycerol (MAG) hydrolase α/β-hydrolase domain-containing 6 (ABHD6) in WAT is a therapeutic strategy for improving the health of adipose tissue #obesity www.sciencedirect.com/science/arti...

FINALLY! 🔥 See you all TOMORROW, Monday August 18th at 17:00 for early registration and cocktails. Download the full #AdiposeBiology Conference program here: adiposebiology.com/program
Get ready for #ABC2025 @kazaklab.bsky.social @beaudrj.bsky.social @sunglab.bsky.social

Covid and Our Arteries A new study on acceleration of vascular aging adds to the body of evidence

We just learned about a 3rd dimension of how Covid can affect our arteries.
erictopol.substack.com/p/covid-and-...

Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes Brown adipose tissue hosts a distinct population of Treg cells that preserves thermogenesis by controlling local interferon-γ production.

Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes | Science Immunology www.science.org/doi/10.1126/...

Detailed Map of Weight Loss Induced Changes in Adipose Tissue Results reveal that weight loss has significant effects on cellular processes that are known to affect metabolic health and longevity.

www.genengnews.com/topics/trans...

Congrats! Interesting

Glycerolipid Cycling in Thermogenesis, Energy Homeostasis and Signaling | Physiological Reviews | American Physiological Society Mammals maintain body heat by adaptive energy expenditure through different organ specific mechanisms. The glycerolipid/free fatty acid cycle (glycerolipid cycle), encompassing triglyceride lipolysis ...

Excited to share our timely and comprehensive review published in Physiological Reviews, bringing together insights from multiple leading labs in metabolism: Marc Prentki and Murthy Madiraju, Shingo Kajimura, @denispblondin.bsky.social, and Christopher Nolan.

journals.physiology.org/doi/abs/10.1...

Congratulations

I've been doing this for 30 years & I still can't believe that when people ask me what I do for a living I get to tell them "I'm a scientist". It feels like a kid's fantasy career that they dress up as for Halloween, like "astronaut" or "pirate". I feel very lucky I get to do this day in & day out.

The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT Nature Communications - Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown...

Today in @naturecomms.bsky.social we show the #FutileCreatineCycle plays a key role in #thermogenesis, independent of UCP1. We also challenge the belief that brown adipocytes lack enough ATP synthase for thermogenesis. Congrats to Jakub Bunk! @mcgillgci.bsky.social

Full paper: rdcu.be/egoV7

For Canadian cancer researchers concerned about travelling to the US (🙋🏼‍♂️), please check out and plan to be at the Canadian Cancer Research Conference in Calgary this November. All welcome. www.ccra-acrc.ca/conference/

1 day left to apply!

Check out our First Person Language Guide: Addressing Weight Bias.

This guide aims to support the development of non-stigmatising research, project outputs and other communications. Thank you @xramossalas!

Download here: easo.org/person-first...

Spilling the skinny on fat cells!

@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO

Interested in studying cancer metabolism, recurrence & translational application of machine learning 4 biomarker discovery? NSERC has new programs. Got a MSc, apply for PhD positions in the Marignani Lab, Sept 2025 admissions. www.nserc-crsng.gc.ca/NewsDetail-D...

General 1 — Boston Ithaca Islet Club / BIIC

Looking forward to welcoming colleagues and friends to the Boston-Ithaca Islet Club meeting hosted this year at the CRCHUM in Montreal, 5,6 April. There's still time to register (closing April 4 th)! www.bostonithacaisletclub.com/32nd-meeting-1.

Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature Metabolism Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...

After ~8 years, happy to share work done w/
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!

www.nature.com/articles/s42...

#science #biotech #cancermetabolism
Thread below:

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress - Nature Cell Biology Zhai, Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy s...

💫NEW: Li & co report a central role for #AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy stress during #tumor growth.
👉🏿https://rdcu.be/d8apH
www.nature.com/articles/s41...

Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/

www.encodeproject.org/single-cell/...

Happy New Year, everyone, and welcome to UdeM's first Bluesky account in English! (Our French one, @umontreal.ca , launched a month ago.) 🎓✨ If you're part of our community – or just want to learn more about what we do and what research we're engaged in – subscribe, share and say hello! #umontreal

It is finally here! Check out our website www.adiposebiology.com/registration with @kazaklab.bsky.social & @twinsdad0603.bsky.social, partnered with Sable Systems! See the speaker list, venue info, preliminary program, and registration deadlines.

📍Montreal, Canada
📅Aug 19-20, 2025
#adiposebiology

Early bird Registration is now open for the inaugural
Adipose Biology Conference: www.adiposebiology.com/registration

Amazing speakers. We have many slots for short talks from trainees and ECRs.

📍Montreal, Canada
📅Aug 19-20, 2025

#adiposebiology #adiposebiology2025
@sablesys.bsky.social

WORKING LIFE As women in academia, having children can feel impossible. Talking about it makes us feel less alone. conceputal illustration of multiple people looking to center, with conversation bubbles with baby and academic related drawings inside

"The academic structure … makes planning for a family feel like an impossible luxury."

In this #ScienceWorkingLife, two postdocs share how, as women in academia, having children can feel impossible—and how talking about it makes them feel less alone. scim.ag/49BKZgp

@cellreports.bsky.social being artistic with the fabulous fat cells 🤩👏