First paper of 2026! We started with 4 genetic variants from GWAS and ended with a potential lncRNA therapeutic for ER+ breast cancer. Spent hours with co-senior author @stacedw.bsky.social bouncing ideas around, discussing results and potential mechanisms. Loved every minute! rdcu.be/eXVnl
Happy new year/paper!
A new tech (scG2P) maps genotype (DNA) to phenotype (RNA) in single cells, bringing together the worldviews of genetic & transcriptional heterogeneity. With scG2P we define how mosaicism drivers increase clonal fitness in the aging esophagus
aacrjournals.org/cancerdiscov...
FinnGen public release October 14: The first set of clinical laboratory value GWAS results. FinnGen logo and a black-and-white abstract genetic data pattern at the bottom. Graphics credits: Aalto University, Visual Communication Design Team.
Just in time for #ASHG2025, a new FinnGen public data release is live!
This release features the first clinical laboratory value association results. Analyses cover 383 lab measurements (OMOPIDs) with data from ≥1,000 participants each.
Access the results here: www.finngen.fi/en/access_re...
acmgscaler: an R package and Colab for standardized gene-level variant effect score calibration within the ACMG/AMP framework academic.oup.com/bioinformati... 🧬🖥️🧪 github.com/badonyi/acmg... #Rstats
Hmmm...I wonder if the data are uploaded but private. Worst case it looks like PLOS allows readers to make comments, so it might be worth bringing to their attention if they don't fix it soon!
That said, it seems like there's a similar project in SRA already (BioProject ID PRJNA1281840).
Poster Image with a woman yelling into a megaphone.; Title reads: Fight for Science. Bubbles read: 3:00pm, Rally, Oct 17th.; Subtitle reads: Health and Science for the People!; A pin emoji with text: 200 Independence Ave SW, Washington DC; a Virtual Call emoji with text: Join us virtually at: bit.ly/4mXwrfY ; bottom corner has QR code and a logo for Stand Up For Science
FIGHT FOR SCIENCE RALLY ✊🌏
⏰ WHEN: October 17th, 2025
📍WHERE: 200 Independence Ave SW, Washington DC!
RSVP to JOIN THE FIGHT IRL: zurl.co/LayiM ‼️
📲 Join us Virtually!: zurl.co/Um47l
Delighted to have our preprint led by @lvchosen1.bsky.social
up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells
biorxiv.org/content/10.1...
🧵 below ...
A key point here is the disconnect in awareness between researchers and everyone else (of course this is a feature, not a bug, for the government)
“[T]he effects from increases or decreases in funding can take upwards of seven years.”
An excellent systematic analysis of RBPs by @quaidmorris.bsky.social and colleagues (with a tiny contribution from us) #RNAsky #RNAbiology
🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!
I am SO excited to receive this award and even more so to receive it along with @rogerslabucd.bsky.social!!!Congrats to all of the awardees and thank you for your support! We look forward to putting this award to work! 🙏🏾🎉
Standard methods are equivalent to a flashlight, looking at each gene independently. We combine signals from multiple genes, turning a floodlight onto the genome.
Excited to share my first PhD paper in the @sbmontgom.bsky.social lab with @tamigj.bsky.social (www.biorxiv.org/content/10.1...)! Standard QTL methods treat each gene independently. But what if a single variant regulates multiple nearby genes at once - what we call “allelic proxitropy”? 🧵 ⬇️
"I am so scared about doing this, but I am trying to be brave for my kids because it's only going to get harder to speak up....Maybe I'm putting my kids at risk by doing this. And I'm doing it anyway because I couldn't live with myself otherwise."
apnews.com/article/nih-...
My personal takeaways from Dorrestein's talk on microbiome-derives molecules and big data metabolomics:
- should have taken biochem
- I need to dig more into metabolomics
- SCFAs are so important y'all. Eat your fiber
- also bile acids evidently
- dietary assessments suck 1/2
#HCMPHSymposium
👀 You know who has the chops to give some EXCELLENT #SummerFightForScience Teach Ins?
🧪 👩🏫 Middle and High School science teachers 👀
#StandUpForScience
New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky
A protest graphic titled “TRUMP’S FIRST 100 DAYS” with bold red blocks reading “SCIENCE UNDER SIEGE.” Black paint drips from the top, and a grayscale crowd of protestors hold signs like “Save Science,” “Keep Your Hands Off Our Pipettes,” and “No Science, No Future.” A U.S. flag waves on the right.
🚨SCIENCE UNDER SIEGE: TRUMP’S FIRST 100 DAYS 🚨
In his first 100 days, Trump has declared war on science—slashing budgets, censoring facts, and meddling in research. From climate to cancer care, real lives are at risk.
Here’s a thread on Trump’s assault on science so far—and why it matters: (🧵)
Kennedy wants to track people with Autism.
This is a violation of HIPAA.
The US government has dismantled all covid related tracking & reporting despite people dying and becoming disabled every day… Yet they’re establishing a registry to track autism cases and plan to access people’s private medical data.
Autism doesn’t kill. It’s not contagious. This is eugenics
What Republicans are fighting is literally visual symptoms of disability. Being so different, you're difficult and not helpful to the party. That's eugenics. Autism you can hide is fine. Disability you can't needs to be eradicated.
The reason autism has such a stigma in the first place is because so many people who have it are able to mask well enough to pass or are just considered quirky by ignorant friends and family. People with nonverbal or profound autism can't and historically are treated as burdens rather than people.
RFK's sinister autism registry reeks of eugenics and must be fought. That said? Autism is one of the most undiagnosed conditions there is. Only 1 in 4 people who have it are officially diagnosed, and testing is expensive. This cartoonisly evil plan to get rid of autism is dumb on a most basic level.
my endorsement for any democratic presidential candidate who promises to send the entire DOGE team to prison
I don't get why none of the foundations I've written grants for in the last 2 years want to fund me. I try so hard. I get good results. I get a lot done for not a lot of money. I integrate science & art, am good at community organizing, & get science into places where there currently isn't much.
Vance and the pope, Hegseth's signal groups, Rubio unraveling the state department, RFK Jr.'s antics—it's a lot.
Don't lose sight of the way they are destroying due process.
278 US "deportees" are still in CECOT. They're stonewalling on Abrego Garcia. Others have plain disappeared.
Gift link.
What a great initiative. It's so important to hear the stories of silenced scientists. 🧪 ⚛️ 👩🔬
His girlfriend’s aunt Grace Layva says she and her family made numerous calls looking for him before they found out he was being detained in the Florence Correctional Center, which Immigration and Customs Enforcement uses to detain people. Another family member drove to the detention center, about 70 miles northwest of Tucson, but said officials wouldn’t provide any information or release him. ICE did not respond to a request for comment about the wrongful detention. The family later provided officials with his birth certificate and social security card. “He did say he was a U.S. citizen, but they didn't believe him,” Layva said. “I think they would have kept him. I think they would have if they would have not got that information yesterday in the court and gave that to ICE and the Border Patrol. He probably would have been deported already to Mexico.”
A Border Patrol official arrested a 19 yo citizen from Albuquerque in Arizona who didn’t have ID on him, claimed he ‘admitted’ to illegally crossing the border, abducted + ICE imprisoned him for 10 days, and would have deported him to Mexico if his family hadn’t tracked him down and provided his ID.
A unified analysis of atlas single-cell data genome.cshlp.org/content/earl... 🧬🖥️🧪 github.com/chenhcs/GIANT
Notable challenges posed by long-read sequencing for the study of transcriptional diversity and genome annotation genome.cshlp.org/content/35/4... 🧬🖥️🧪
