Yosuke Kumamoto

Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation Dendritic cells (DCs) play a crucial role in bridging innate and adaptive immunity by presenting antigens to prime antigen-specific T cells. Conventional DC (cDC) type 2 cells (cDC2s) are a phenotypi...

A new review on cDC2 subsets in CD4T cell regulation is out!! cDC2サブセットによるCD4T細胞の制御に関する新しいレビューが出ました!!
onlinelibrary.wiley.com/doi/10.1111/...

Research Specialist A/B University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...

The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...

Happy to share that our collaboration with Christina
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!

www.pnas.org/doi/abs/10.1...

Thanks!!

Frontiers | The role of IL-2 in type 2 immunity Type 2 immune responses are essential for protective immunity against helminth parasites and for promoting tissue repair, but they can also drive allergic in...

Happy to share this mini review on IL-2 in type 2 immunity. IL-2 may be an old cytokine but there's still a lot to learn!!
www.frontiersin.org/journals/imm...

AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation - Nature Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.

Big congratulations, Teruyuki Sano and his team on their publication in @nature.com ! It was great to collaborate this wonderful study with his team.
We continue to contribute more to science together, especallly in the field of immunology!
www.nature.com/articles/s41...

IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis Immune-microbiota interactions are required to maintain host homeostasis. Kim et al. identified that steady-state sensing of IL-10 by interstitial macrophages (IMs) prevents spontaneous lung inflammat...

Thrilled to share that our paper is now published in Immunity @cp-immunity.bsky.social ! 🎉 It’s been a long journey, and I’m incredibly grateful to all my co-authors—especially Dr. Teruyuki_Sano—for your dedication. This wouldn’t have been possible without you!
www.cell.com/immunity/ful...

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graphical abstract

Finally online - sharing our findings that #Lyme disease bacteria can live in female reproductive organs for over a year and increase risk for gynecological disease!!! We found this increased risk in mice and humans! 😱 (thread below)
www.medrxiv.org/content/10.1...

Thanks!!

Absence of c-Maf and IL-10 enables type I IFN enhancement of innate responses to LPS in alveolar macrophages Abstract. Alveolar macrophages (AMs) are lung-resident myeloid cells and airway sentinels for inhaled pathogens and environmental particles. While AMs can

So happy to share our latest paper on #AlveolarMacrophage responses to low-dose #LPS led by @pamelialim.bsky.social!AM #innate responses are enhanced by IFN-beta due to low c-Maf and IL-10 expression, with implications for AM responses to respiratory infections and environmental exposure. #ImmunoSky

Thanks!!

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation - Nature Communications A subset of migratory type 2 conventional dendritic cells marked by CD301b expression (CD301b+DC), are required specifically for the development of Th2 cells. Here authors show that at the mechanistic...

CD301b+ DC-derived IL-2 dictates CD4+ T helper cell differentiation
www.nature.com/articles/s41...
@naturecomms.bsky.social

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation - Nature Communications A subset of migratory type 2 conventional dendritic cells marked by CD301b expression (CD301b+DC), are required specifically for the development of Th2 cells. Here authors show that at the mechanistic...

Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone.
www.nature.com/articles/s41...

Come join our faculty! We’re hiring.

Post-Doctoral position in cancer immunology and immunotherapy, Institut Pasteur, Paris, France - Research Deciphering the role of intra-tumoral dendritic cells in the dynamic controlof CD4+ and CD8+ lymphocytes in lung cancer. A 3-year, post-doctoral position is available in the Guermonprez lab at Institu...

Interested in cellular cross-talks between dendritic cells and T lymphocytes in lung cancer? Our team is recruiting a postdoctoral associate in immunology at Institut Pasteur Paris!
research.pasteur.fr/fr/job/post-...

Sign the Petition Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
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Hello all. Finally made my way to 🦋. Looking for my people in host defense, innate immunology, bacterial pathogenesis and lung biology! Please help me find you!

Beautiful work. Congratulations!!

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...

*PhD project available funded by BBSRC WoH DLP,*. Are you interested in viral and fungal immunity? Keen to use learn the latest cutting edge technologies to address this working with partners at UKHSA? If yes then please reach out. Further details at: www.surrey.ac.uk/bbsrc-wessex...

Hello Friends, I created a 5th #immunology Starter Pack. If you're an immunologist and you don't see yourself on the lists, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

go.bsky.app/QSEPDoj

go.bsky.app/Mdbpk7h

Our manuscript preprint is out!

We are looking for a research faculty to join the lab. Taking tissue engineering and regenerative immunology to the next level - deciphering immune-stromal networks that regulate tissue structure in health, injury and disease, especially aging! apply.interfolio.com/161101

Interesting!! Congratulations!!

Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice - Nature Communications Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2 and type 17 allergic respo...

Nice work by @drpetercook.bsky.social, @profandrewmac.bsky.social & Co. Congratulations to the team!! www.nature.com/articles/s41...

#postdoc opportunity in #immunology and #microbiome research at Weill Cornell Medicine - Cornell University in New York City! For details about the position see the image below. For details about the lab: robertsinstitute.weill.cornell.edu/arifuzzaman-...
Please share!

Hi Bluesky! I’m Priya Devarajan, an immunologist studying how our immune system fights respiratory infections like influenza. My new lab @Stony Brook Medicine studies B/T cell responses, tissue-resident memory, respiratory immunity, and immune aging (www.thedevarajanlab.com). Excited to connect!

Working with a great team to organize
@keystonesymposia.bsky.social on "#LongCOVID and Other Post-Acute Infection Syndromes #PAIS" #KSLongCOVID26
@patientled.bsky.social @daltmann.bsky.social

August 10-13, 2025 | Santa Fe

Hope to see you there!

keysym.us/KSLongCOVID26