New preprint on the limits of detecting higher-order interactions in microbial communities.
www.biorxiv.org/content/10.6...
We find that the dominance of additive and pairwise interactions on community function may not reflect biological simplicity, but fundamental limits of statistical detection.
New preprint out on bioRxiv!
www.biorxiv.org/content/10.6...
Can conjugative plasmids be used to control plasmid and pathogen spread?
Follow me down the rabbit hole that led to this story ๐งต
New pre-print with @wtmatlock.bsky.social!!!
www.biorxiv.org/content/10.6...
What shapes the distribution of plasmids across bacteria? Our paper shows that conjugative plasmids actually have a very narrow distribution compared to mobilizable plasmids. Conjugative systems restrict plasmid transfer!
The incomparable Zong roped @wvschaik.bsky.social and I into a comment for Nature Comms on microbiome mediated colonisation resistance to combat Klebsiella
www.nature.com/articles/s41...
What a fantastic new addition to my lab! ๐
Welcome @albertohca.bsky.social to the @uam.es family! Stay tuned for the science weโre going to build together in the coming years!
A short research stay in 2019 (back in the pre-COVID era) at Josรฉ R. Penadรฉs lab turned into the third chapter of my PhD and today it finally sees the light.
How does population density affect evolutionary trajectory?
Microbes construct their own niche which in turn reshapes their evolution.
Preprint drop from grad student @noahhoupt.bsky.social whose evolution experiments featured blue/white colonies, 1000 generations, a lab move, and much more!
New #BehindThePaper for our latest paper in @natcomms.nature.com (rdcu.be/e2qMK)
Secret Invasion: Strain Fate Across Microbiomes
Cover illustration by Helena Klein (@illuzation.bsky.social).
communities.springernature.com/posts/secret...
๐งฌNew paper out! We report the first isolation of viable B. bacteriovorus predators from human gut microbiota. www.frontiersin.org/journals/mic.... Great work of Mario Romero @migueldiezfdz.bsky.social @josete600.bsky.social and @rosacampo.bsky.social
Pictured is a map of plasmids, which are DNA molecules that can be transferred between bacteria. Each ring and dot represents an evolved plasmid and a mutation, respectively. Image credit: Paula Ramiro-Martรญnez.
In this issue: Fresh light on horse evolution, mangrove restoration as coastal flood protection, and the links between aerobic metabolism and planetary oxygenation. In PNAS: https://ow.ly/yB6J50Y5ykK
New paper out in PNAS!!! ๐
Do more plasmid copies mean faster evolution?
๐งต Dive into the story
www.pnas.org/doi/10.1073/...
New paper out in @pnas.org, and it made the cover! ๐๏ธ
We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally ๐ค๐๐ก๐โ plasmids evolve.
โผ๏ธCheck Paulaโs ๐งต and the paper๐
๐ฃ๐น๐ฎ๐๐บ๐ถ๐ฑ ๐บ๐๐๐ฎ๐๐ถ๐ผ๐ป ๐ฟ๐ฎ๐๐ฒ๐ ๐๐ฐ๐ฎ๐น๐ฒ ๐๐ถ๐๐ต ๐ฐ๐ผ๐ฝ๐ ๐ป๐๐บ๐ฏ๐ฒ๐ฟ
www.pnas.org/doi/10.1073/...
Application deadline for this postdoc position in my group closing next week ๐ฆ thank you all who have shared so far!
Lab ready. Looking forward to what comes next here.
New preprint out! ๐ฃ๐จ
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity ๐ฆ
#Microsky
Iโm excited to share this article from my PhD, exploring the role and prevalence of peptide deformylases! It has been a truly enriching and fascinating scientific journey. Thank you, @amazeld.bsky.social, for welcoming me into your lab and giving me the scientific freedom to follow my curiosity!
Our story on plasmid streamlining is now published in PLoS Biology! With @andrewmatthews.bsky.social and @sonjalehtinen.bsky.social
#MicroSky #Mevosky
journals.plos.org/plosbiology/...
I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics!
(1/n) www.biorxiv.org/content/earl...
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
Enhorabuena!! ๐๐ผ๐๐ผ
2/ ๐ค This project is carried out at @cnb-csic.bsky.social is conducted in consortium with @tmcoque.bsky.social (Instituto Ramรณn y Cajal de Investigaciรณn Sanitaria).
1/ Antibiotic resistance causes โ than 1 M deaths each year and understanding why this happens is key to stopping it.
With #HealthResearch support, @sanmillan.bsky.social is investigating how different plasmids (DNA fragments) coexist in bacteria and confer resistance.
https://tinyurl.com/3bysv6cr
New paper out ๐ When an antibiotic-resistant E. coli strain lands in our gut microbiome, whether it will get established or not depends on the ecological context. We studied how other microbes, nutrients, and antibiotic exposure shape its fate.๐
Can we leverage bacterial competition for targeted replacement of harmful strains? Maybe! Our recent piece in @natmicrobiol.nature.com provides a theoretical framework and a set of experiments to show what it might take: www.nature.com/articles/s41...
Our paper โGlobal dissemination ofโฏnpmA mediated panโaminoglycoside resistance via a mobile element in Gramโpositive bacteriaโ is now in @natcomms.nature.com. Part of my freshly defended PhD, so doubly happy! ๐๐
๐งต (1/14)
www.doi.org/10.1038/s414...
Great to have worked on this with Alex Hall, @mboum.bsky.social , Markus Reichlin, Katia R. Pfrunder-Cardozo, Nicholas Noll, and Adrian Egli; such a great team!
๐จ Excited to share our new paper is out! ๐
We show how interactions within gut microbiomes allow certain antibiotic-resistant E. coli strains to persist even without antibiotics, helping explain how resistance is maintained in the human gut.
Now published in @natcomms.nature.com rdcu.be/eOf63
New(ish!) paper on how within-host competition and antibiotic resistance shape the fitness of Streptococcus pneumoniae serotypes, out in August in Plos Biology. journals.plos.org/plosbiology/...
New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Do plasmids really move around that much? Well, maybe not always
Thrilled to have contributed to this story with two of my favourite microbiologists: @jrpenades.bsky.social & @sanmillan.bsky.social
This great work was led by Akshay Sabnis & @wfigueroac3.bsky.social
www.cell.com/cell-reports...
