Journal of Leukocyte Biology

Neutrophil progenitor cell therapy rescues host defense against Staphylococcus aureus in murine chronic granulomatous disease Neutrophil progenitor therapy rescues CGD mice from lethal Staphylococcus aureus infection

New data from Kristina Hinman, Jason Machan & Craig Lefort @brown.edu shows "#Neutrophil progenitor cell therapy rescues host defense against #StaphylococcusAureus in murine #ChronicGranulomatousDisease"

Sirtuin 1 is an endogenous NETosis inhibitor that becomes dysfunctional in diabetes Neutrophil sirtuin 1 naturally inhibits neutrophil extracellular trap formation (NETosis) under healthy conditions; its reduced activity in diabetes leads

Starting off our March 2026 issue of #JLB - "Sirtuin 1 is an endogenous #NETosis inhibitor that becomes dysfunctional in #Diabetes" by Liang De Wang & colleagues

The macrocyclic peptide rhesus theta defensin 1 activates interferon and antiviral pathways in human monocytes RTD-1 stimulates phosphorylation of Y701 residue of STAT1 and activates antiviral and interferon-stimulated gene expression pathways in a type I interferon

Interview #3 - Prasad Tongaonkar & Michael Selsted @usc.edu tell the story behind "The macrocyclic peptide rhesus theta defensin 1 activates interferon and antiviral pathways in human monocytes"

Human M-MDSCs impair neutrophil migration in the infectious microenvironment M-MDSCs limit the number of neutrophils responding and the migration distance towards a source of infection when leaving a model blood vessel.Blocking IL-1

Interview #2 - Hannah Weppner & Laurel Hind @colorado.edu explain their recently published paper "Human M-MDSCs impair neutrophil migration in the infectious microenvironment"

RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization Rabaptin facilitates fast endosomal recycling, which activates Rac-PAK signaling and reinforces actin polymerization at the neutrophil front to support mot

Interview #1 - Daniel Kim from the lab of Qing Deng @cancer-inst-purdue.bsky.social discusses "RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization"

Cover of iSLB Vol 1 2026 https://www.leukocytebiology.org/assets/docs/iSLB/Vol%201%202026%20iSLB.pdf

In Vol 1 2026 of @leukocytebiology.bsky.social #iSLB newsletter, read THREE #JLB Author Interviews!
www.leukocytebiology.org/assets/docs/...

Register now for our next free webinar by Dr. Shruti Rawal on "A microRNA mediated regulation of macrophage immunometabolism in diabetes-associated atherosclerosis"
www.leukocytebiology.org/index.php?op...

Single-cell transcriptomic analysis reveals RNA-binding protein dysregulation in immune checkpoint inhibitor–induced colitis RNA-binding protein dysregulation in immune checkpoint inhibitor–induced colitis.

Haobei Ran, Lipan Zhang and colleagues report that "Single-cell transcriptomic analysis reveals RNA-binding protein dysregulation in #ImmuneCheckpointInhibitor –induced #Colitis"

TNFR2-targeting biologics: Molecular mode of action, possible applications, and future developments Clustering of TNFR2 leads to its activation and can be triggered by rationally designed TNFR2-binding molecules that either initiate the self-association o

Read the new Review from Olena Zaitseva and Harald Wajant - "#TNFR2-targeting biologics: Molecular mode of action, possible applications, and future developments"

Noneosinophilic leukolectin proteins occur in cytoplasmic granules in some human leukocytes In adult and placental blood, some neutrophils (denoted lectophils) express novel leukolectin proteins, while placenta additionally displays leukolectin pr

Mirushe Miftari and Bernt Walther @unibergen.bsky.social report that "Noneosinophilic #Leukolectin proteins occur in cytoplasmic granules in some human leukocytes"

CD200R1 promotes the development of murine γδ17 T cells CD200R1 supports the development of murine IL-17–producing γδ T cells.

New data from Holly Linley, Amy Saunders and colleagues @lydiabeckeriii.bsky.social @manchester.ac.uk shows that "#CD200R1 promotes the development of murine #γδ17 #Tcells"

Tracing MR1 expression across tissues to find the perfect MAIT Using genetically modified mice, Deng et al. found that MR1 presentation of riboflavin metabolites to MAIT cells is highest in lung and peritoneal macropha

@christyclutter.bsky.social & @danieltleung.bsky.social at @uofuhealth.bsky.social discuss a recent landmark study in mucosal-associated invariant T (#MAIT) cell biology! Read the News and Views article now - "Tracing #MR1 expression across tissues to find the perfect MAIT"

Biodegradable microparticles promote anti-inflammatory innate immune memory through a size- and mTOR-dependent process Biodegradable poly(lactic-co-glycolic acid) microparticles promote anti-inflammatory macrophage responses and induce anti-inflammatory innate immune traini

Work from Ed Lavelle lab @tcddublin.bsky.social @tbsi-tcd.bsky.social led by Roisin Lynch shows that "Biodegradable microparticles promote anti-inflammatory innate immune memory through a size- and #mTOR-dependent process"

CD101: A versatile molecule associated with immunoregulatory and antimicrobial functions CD101 exhibits negative costimulatory, immune-modulatory, inflammatory, and antimicrobial functions dependent on the T lymphocyte and myeloid cell subset o

Jochen Mattner @fau.de provides a comprehensive Review of #CD101 - "CD101: A versatile molecule associated with #Immunoregulatory and #Antimicrobial functions"

The selective estrogen receptor modulator bazedoxifene affects the metabolism and functions of human neutrophils High doses of bazedoxifene increase cytokine release from neutrophils while impairing antimicrobial functions.

New data from Elena Lonina, Martin Pelletier and colleagues @ulaval.ca @crchudequebec.bsky.social - "The selective estrogen receptor modulator #Bazedoxifene affects the #Metabolism and functions of human #Neutrophils"

Leukocyte immunoglobulin-like receptor subfamily B member 1 expression defines CD8+ T cell exhaustion in acute myeloid leukemia LILRB1 drives cytotoxic lymphocyte dysfunction in AML by suppressing CD8+ T cell and CD16+ NK cell effector programs, enabling leukemic immune evasion.

Yuran Miao, Liwan Lin, Zhixi Chen and colleagues show that "Leukocyte immunoglobulin-like receptor subfamily B member 1 (#LILRB1) expression defines CD8+ #Tcell #Exhaustion in acute myeloid #Leukemia"

A conserved upstream element in the mouse Csf1r locus contributes to transcription in hematopoietic and trophoblast cells This work describes the functional characterization of a regulatory element within the Csf1r locus.

Emma Maxwell, David Hume, Sebastien Jacquelin and colleagues report that "A conserved upstream element in the mouse #Csf1r locus contributes to transcription in hematopoietic and trophoblast cells"

Targeting CaMKIIδ overcomes therapy resistance in acute myeloid leukemia by suppressing the STAT3/CDK6/BCL-2 survival axis CaMKIIδ is activated in leukemia stem/progenitor cells of acute myeloid leukemia (AML) patients and associated with high tumor burden and poor outcome. Blo

Zhaoxing Wu and colleagues report that "Targeting CaMKIIδ overcomes therapy resistance in acute myeloid #Leukemia by suppressing the #STAT3/#CDK6/#BCL-2 survival axis"

IL-36 mediates immune activation in Sjögren's disease and may represent a novel biomarker of disease IL-1 family signaling networks are dysregulated in salivary tissue, and IL-36 mediates immune activation in Sjögren's disease.

New research from Bayan Alhaddad, Theresa Wrynn and colleagues @ubuffalo.bsky.social - "IL-36 mediates immune activation in #Sjögren’s disease and may represent a novel biomarker of disease"

Interferon stimulation and NKG2D expression drive enhanced natural killer cell antibody-dependent cellular cytotoxicity against viral infections Integrated single-cell transcriptomics and functional assays reveal interferon signaling and NKG2D expression as drivers of antibody-dependent cellular cyt

Leslie Chan @stanfordimmunology.bsky.social, Catherine Blish @blishlab.bsky.social and colleagues @stanfordmedicine.bsky.social identify #Interferon activation and #NKG2D expression as key determinants of #NKcell antibody-dependent cellular cytotoxicity (#ADCC) in #SARS-CoV-2 infection

RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization Rabaptin facilitates fast endosomal recycling, which activates Rac-PAK signaling and reinforces actin polymerization at the neutrophil front to support mot

Daniel Kim, Ramizah Syahirah, Qing Deng and colleagues @cancer-inst-purdue.bsky.social report that #RABEP1 is necessary for #Neutrophil migration - "RABEP1 regulates neutrophil migration via endosomal recycling and actin polymerization"

Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from old hosts against antibody-opsonized Streptococcus pneumoniae Abstract. Age-related decline in neutrophil function reduces vaccine protection against Streptococcus pneumoniae. In vaccinated hosts, neutrophil activatio

New findings from Shaunna Simmons, Annabel Rivera & @elsaawesomepmns.bsky.social @ubuffalo.bsky.social - "Basal activation of #ERK1/2 blunts the antimicrobial activity of #Neutrophils from old hosts against antibody-opsonized #StreptococcusPneumoniae"

H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability H195Y mutation of transcription factor IKZF3 impairs transcription repression activity and increases protein stability.

New data from Heidi Rysan, @rdekoter.bsky.social and colleagues @schulichmeddent.bsky.social - "H195Y mutation of #IKZF3 identified in a mouse model of precursor #Bcell acute lymphoblastic #Leukemia impairs transcriptional repression activity and increases protein stability"

ICAM-1 and vascular matrices coordinate skin S1 macrophage formation from blood PDGFRα lineage monocyte Leukocyte-endothelial interface ICAM-1 structures (green) supports apical PDGFRα lineage (yellow) CD68+ (magenta) monocyte adhesion required for extravasat

Li and colleagues uncover new insights into skin #Macrophage formation - "#ICAM-1 and vascular matrices coordinate skin S1 macrophage formation from blood #PDGFRα lineage #Monocyte"

Neutrophils and the NLRP3 inflammasome: a tale of proteases, kinases, and inflammation Cell type–specific mechanisms modulate Nod-like receptor family pyrin domain containing 3 inflammasome activation in macrophages and neutrophils, shaping i

"#Neutrophils and the #NLRP3 #Inflammasome: a tale of #Proteases, #Kinases, and #Inflammation" - read the new Review by Vinicius Leal @uspoficial.bsky.social & Alexander Weber @unituebingen.bsky.social

Association between absolute blood eosinophil count and carotid plaque and coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis (MESA) In a large, ethnically diverse US population, blood eosinophil count was associated with carotid arterial plaque and coronary artery calcium presence and s

The February 2026 issue of #JLB kicks off with "Association between absolute blood #Eosinophil count and #CarotidPlaque and #CoronaryArtery calcification in the Multi-Ethnic Study of #Atherosclerosis (MESA)" by Nyla Mathis, Mats Johansson and colleagues @uw-medicine.bsky.social