Chris Humphries

Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively... Introduction Acute liver failure (ALF) has no effective treatment other than liver transplantation and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. A...

Our trial protocol is out - first-in-human allogeneic macrophages for the treatment of paracetamol liver injury. Can they fill the gap between acetylcysteine and transplant? bmjopen.bmj.com/content/14/1...

The emerging role of alternatively activated macrophages to treat acute liver injury - Archives of Toxicology Acute liver injury (ALI) has a clear requirement for novel therapies. One emerging option is the use of alternatively activated macrophages (AAMs); a distinct subtype of macrophage with a role in live...

My opening Bluesky offer - for anyone interested in how we're pushing the boundaries of research into paracetamol (acetaminophen) poisoning, take a look at our recent article here: link.springer.com/article/10.1...

(Trial protocol due out soon!)