We have a postdoc position available in our lab at the @mrclmb.bsky.social - the project is on exploring targeted protein degradation in dendritic cells to facilitate T cell-mediated immune responses - see the link below for more information. Deadline this Monday!
www.nature.com/naturecareer...
Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
Visualisation of the inner part of the human nuclear pore, with the inner part of the ring in green, and the outer part highlighted in red, to look like a Christmas wreath
Day 24 of making proteins for #ArtAdventCalendar
The nuclear pore complex is a huge pore made of hundreds of proteins, that allows the flow of nucleic acids and proteins between the nucleus and cytoplasm. It also looks like a wreath!
Merry Christmas!
More projects: e-nox.net/portfolio/
#SciArt
We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
My "News & views" was published today @natmethods.nature.com
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Visualisation of a membrane-bound protein (green) in a nanodisc, which is a tiny section of lipid membrane (clear), and you can see the two stabilising bands (pink/purple) that go around the disc
Day 6 of making proteins for #ArtAdventCalendar
This is a "nanodisc", which is a tiny section of lipid membrane, just big enough to hold a single membrane-bound protein, and holds the structure stable enough to probe its structure
More projects: e-nox.net/portfolio/
#SciArt
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Pre-pore and cis pores formed by full length perforin-2 during antigen escape from early phagosomes
Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments?
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
The EMBO Gold Medal 2025 was awarded to Tanmay Bharat and David Bikard: https://www.embo.org/press-releases/embo-gold-medal-2025-awarded-to-tanmay-bharat-and-david-bikard/ 🧪
At #CellBio2025, the EMBO Gold Medal was handed over to David Bikard in recognition of his pioneering work on #GeneEditing.
Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science.
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
Visualisation of the structure of HLA-A2, presenting a peptide (protein fragment). HLA-A2 is shown in blue/purple with its surface translucent and an internal ribbon showing its structure. The peptide is shown bound to a crevice in magenta.
Day 5 of making proteins for #ArtAdventCalendar
Today it's HLA-A2, which is critical for the immune system. They present fragments of intra-cellular proteins to CD8+ T cells, which can initiate a targeted immune response.
More projects: e-nox.net/portfolio/
#SciArt
BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...
Check out the latest paper from Leo James and William McEwan which explains the science behind LMB spin out TRIMTECH Therapeutic's TRIMTAC® degraders ⤵️
Activation of CASM recruits BLTP3A to the surface of damaged lysosomes through an interaction with mATG8 proteins.
🧬 CRN Team De Camilli found that BLTP3A/UHRF1BP1 binds VAMP7 vesicles to lysosomes and activates the CASM pathway after lysosome damage. This drives mATG8 recruitment and helps restore lysosome integrity.
🔗 Check out the full #publication to read more about their findings: bit.ly/4o27nF0
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: www.biorxiv.org/cgi/content/...
This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070
GPR34 is a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells @jem.org
rupress.org/jem/article/...
An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense.
@cedarssinai.bsky.social
rdcu.be/eNIFY
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Delighted that our latest paper is out @jem.org. An intriguing study led by Ana Cardoso exploring the role of DNGR-1 in mouse dendritic cell precursors.
Looking forward to meeting PFP enthusiasts at the Prato conference on Pore Forming Proteins in June!
⏰ Early Bird Registration deadline - May 16th ⏰
www.pratopores.org/speakers
#PFPsky
At last, direct demonstration that tapasin dependent MHC-I molecules experience greater tapasin filtering, resulting in less diverse MHC-I immunopeptidomes that are enriched in high affinity peptide-MHC-I complexes. Well done Andy and Rachel! links.email.frontiersin.org/ls/click?upn...
Wow! Amazing response in the first few days of registration opening for www.emds2025.com
Be sure to register early to avoid disappointment.
🚨 Abstract deadline is FRIDAY 30th MAY
(Sneak peak of @profandrewmac.bsky.social rehearsing for the 'Scotland Experience' social.)
👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social
www.cell.com/immunity/abs...
Immune Cell Interactions in Development, Homeostasis and Immunity Fanhams Hall, Hertfordshire, UK 23-26 February 2025 Group photo
Thank you to organisers Philippe Bousso,
Gillian Griffiths @griffithslab.bsky.social , Milka Sarris &
Michael Sixt, and everyone who joined us for our 'Immune Cell Interactions in Development, Homeostasis and Immunity' Workshop.
biologists.com/workshops
