Kal Tsanov

Primary tumor chromatin landscape governs metastatic organotropism - Nature Cancer Little is known about how mutations in genes encoding tumor suppressors influence metastatic site selection and whether sustained inactivation of such genes influences tumor maintenance at these sites...

Many thanks to #AmyGladstein & #DavidFeldser for this great perspective on our recent paper @natcancer.nature.com. As they say in it (and have elegantly shown in their work): "‘Flip the switch’ and let nature show you the way!" 🔦🧬🐭
www.nature.com/articles/s43...

Our growing team at @uchicagocancer.bsky.social is building on these concepts, with the goal of translating this knowledge to improved therapies for metastatic cancers. More to come! (4/4)

Huge thanks to everyone who contributed to this team effort #LoweLabMSKCC #LabMassague @danapeer.bsky.social #ChristineIacobuzio #CPCRMSK @ronanchaligne.bsky.social #SAIL #RichardKoche #ERIL, and key funding support from #NCI @jcchildsfund.bsky.social #KatzmanFellowship #GMTEC! (3/4)

As mechanism, we identify distinct epigenomic states that are favored by different metastatic organs and begin to emerge even in premalignant cells. This may be a broader principle w/ implications for the interpretation of tumor genetics & therapeutic targeting of metastatic disease. (2/4)

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence - Nature Cancer Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic growth through KLF4 in the liver, influenced by organ-specific epigenetic states.

🚨Location, location, location! Now out @natcancer.nature.com, the final version of our study showing how a tumor's anatomic site can impact the function of driver gene mutations, using SMAD4 inactivation as in pancreatic cancer as a clinically relevant example: nature.com/articles/s43.... (1/4)

Thank you! Yes, I think I am overdue to renew so that is a good reminder.

Me too! New PI, laser-focused on metastasis (and just getting started on bluesky...) 🙂

Congratulations, Julio!

Thank you so much for all your support, Dana!! Just starting on bluesky -- apologies for the delay... And greetings from Chicago! 🙂

Thanks so much!! Just starting on bluesky -- apologies for the delay... And greetings from Chicago! 🙂