This review highlights the role of #DYRK #kinases in #DNADamageResponse, linking their activity to #cancer progression, while evaluating current DYRK inhibitors and positioning DYRK inhibition as a promising #PrecisionOncology strategy.
#OpenAccess: doi.org/10.1016/j.ge...
This review highlights the bidirectional role of FTO in #GastrointestinalCancers, regulating #OncogenicSignaling, immune evasion, and #DrugResistance, while pointing to FTO-targeted regulators and #AI-driven strategies for therapy. #m6A
#OpenAccess: doi.org/10.1016/j.ge...
This study identifies SPP1+ #macrophages as regulators of #DiscDegeneration, expanding in diseased discs, driving matrix loss via #SPP1, while #exosome-directed #SPP1 blockade restores autophagy and offers a promising therapeutic path.
#OpenAccess: doi.org/10.1016/j.ge...
This review shows how #SymmetryBreaking transforms uniform epithelial tissues into diverse #skin appendages, revealing how intrinsic gradients and mechanical forces orchestrate patterning, regeneration, and disease across organ systems.
#OpenAccess: doi.org/10.1016/j.ge...
๐ข ๐๐ผ๐ถ๐ป ๐๐ ๐๐ต๐ถ๐ ๐๐ฟ๐ถ๐ฑ๐ฎ๐, ๐ ๐ฎ๐ฟ๐ฐ๐ต ๐ญ๐ฏ, ๐ฎ๐ ๐ญ๐ฏ:๐ฏ๐ฌ ๐๐๐ง ๐ณ๐ผ๐ฟ ๐๐ต๐ฒ ๐๐ฝ๐ฐ๐ผ๐บ๐ถ๐ป๐ด ๐๐ฆ๐ ๐๐ง ๐น๐ถ๐๐ฒ ๐๐ฒ๐ฏ๐ถ๐ป๐ฎ๐ฟ "๐ฅ๐ฎ๐ฑ๐ถ๐ผ๐ฏ๐ถ๐ผ๐น๐ผ๐ด๐ถ๐ฐ๐ฎ๐น ๐๐๐ฝ๐ฒ๐ฐ๐๐ ๐ผ๐ณ ๐ฃ๐ฅ๐ฅ๐ง"!
๐ ๐ฅ๐ฒ๐ด๐ถ๐๐๐ฒ๐ฟ ๐ต๐ฒ๐ฟ๐ฒ ๐ณ๐ผ๐ฟ ๐๐ฅ๐๐: https://elearning.eanm.org/course/live-webinar-radiobiological-aspects-of-prrt-march-13-2026
๐ฃ #ESMOGynae26: From laboratory discovery to clinical application, we invite you to contribute to a programme built around scientific excellence and clinical impact.
โฐ Share your research by 31 March 2026
๐ https://ow.ly/bAAX50YrNnv
#esmomeetings
๐ฃ #ESMOBreast26: Collaborations between experts of different countries and areas of expertise, excellent networking opportunities and the latest science and education.
โฐRegister by 8 April for advantageous fees.
๐ https://ow.ly/GbBk50YrNVY
#esmomeetings
This review shows #glycometabolic reprogramming fuels #Osteosarcoma progression via #glycolysis, mitochondrial dysfunction & immune suppression, highlighting metabolic targeting as a promising strategy to overcome therapy resistance.
#OpenAccess: doi.org/10.1016/j.ge...
This study shows that single-cell profiling of #HCC under anti-PD-1 therapy reveals #Tcell exhaustion trajectories linked to tumorโimmune crosstalk, highlighting exhaustion as a key target to improve #immunotherapy outcomes. #SingleCellRNASequencing
#OpenAccess: doi.org/10.1016/j.ge...
Researchers identify NFIA as a key regulator of #BoneHomeostasis, and its loss in mesenchymal progenitors disrupts bone balance by enhancing resorption over formation, linking NFIA deficiency to age-related #osteoporosis. #osteoclastogenesis
#OpenAccess: doi.org/10.1016/j.ge...
#Aging increases susceptibility to #tenofovir-induced mitochondrial toxicity in #RenalStemCells, with a #3D silk matrix model revealing age-specific injury and providing a platform for safer, targeted kidney therapies. @wakeforest.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
Single-cell analyses reveal #VascularEndothelialCells act as non-professional #phagocytes in #Atherosclerosis, where #SRB1 drives apoptotic debris uptake via #adherensjunction and cytoskeleton remodeling, uncovering a novel clearance pathway.
#OpenAccess: doi.org/10.1016/j.ge...
๐ฃ All accepted Proffered Paper, Mini Oral, Poster and ePoster abstracts for #ESMORareCancers26 are now online!
Dive into the latest research advancing sarcoma and rare cancers care.
๐ https://ow.ly/GQI450Yp3SR
#esmomeetings
#Narciclasine induces #MitochondrialApoptosis in #ColonCarcinoma cells by inhibiting the IL-17A/Act1/TRAF6/NF-ฮบB signaling, establishing it as a potent therapeutic agent against #ColorectalCancer.
#OpenAccess: doi.org/10.1016/j.ge...
#Multiomics reveals reduced #FGF21 as a driver of #LiverAging, linking suppressed peroxisome and fatty acid pathways with cell cycle decline; FGF21 restoration boosts #antioxidant defense and regeneration, highlighting a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
This study identified PDCD2 as a prognostic #Biomarker in #Glioma, showing that its overexpression promotes tumor progression and correlates with malignancy & poor survival, marking it as a potential #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
#Multiomics analysis reveals stage-specific targets in #TALL, highlighting CDK6, TUBA1A, TUBB and TYMS dysregulation across maturation stages; repurposed #mebendazole and #gemcitabine show selective #antileukemic activity.
#OpenAccess: doi.org/10.1016/j.ge...
๐ฃ #ESMO26: The registration system is now open!
Join us at an event where multidisciplinary innovation meets global collaboration.
โฐ Big savings if you register before 22 July 2026
๐ https://ow.ly/lg7S50YoACx
#esmomeetings
๐ The 1st EORTC Summit in Clinical Cancer Research is coming!
AI, innovative methodologies, QOL, patientโcentricity, policy & more โ all in one place.
๐
Save the date & help spread the word!
๐ www.eortc.org/summit
#EORTCSummit
This study reveals that the SOX9โMMP10โECM axis drives tracheal fibrosis post-injury via the Wnt/ฮฒ-catenin signaling pathway, highlighting the targeted inhibition of SOX9 as a potent therapeutic strategy in #TrachealStenosis.
#OpenAccess: doi.org/10.1016/j.ge...
#ERStress activates IRE1ฮฑโXBP1s to upregulate hIAPP transcription via an ACGT site, driving ฮฒ-cell dysfunction in #type2diabetesmellitus (#T2DM); blocking #XBP1 splicing with MKC3946 lowers IAPP and improves ฮฒ-cell survival.
#OpenAccess: doi.org/10.1016/j.ge...
This study reveals that Cdc42 deficiency causes enamel defects by disrupting mitochondrial function and inducing oxidative stress in the dental epithelium, highlighting its critical role in ameloblast differentiation.
#OpenAccess: doi.org/10.1016/j.ge...
This review describes the role of DEAD-box RNA helicases as critical hematopoiesis regulators, detailing how their post-transcriptional dysfunction promotes #HematologicalMalignancies and offers avenues for #CancerTherapy.
#OpenAccess: doi.org/10.1016/j.ge...
This review examines how bidirectional brain-body signaling and integrated immune-endocrine pathways drive #MajorDepressiveDisorder, providing perspectives for precision-oriented therapeutic strategies. @wakeforest.bsky.social
#OpenAccess: doi.org/10.1016/j.ge...
Join leading experts at the Ischemic Heart Disease Track at #ICNC2026 and explore the latest in #nuclearcardiology. From PET for sichemia, to CAD debates, post-revascularization chest pain, and INOCA, sharpen your skills for daily practice.
๐ https://bit.ly/4l2SaDP
Primary care professionals play a critical role in the early diagnosis of NENs.
#ThinkNENs Program is here to help โ and it's completely FREE.
โ 60-minute CME-accredited module
โ 7 languages
โ Endorsed by leading NEN societies
Explore here: incalliance.org/think-nens/
#LetsTalkAboutNETs
๐ข You can still join us today!
The ESTRO Gyn-SMART community invites you to a peer-to-peer discussion on late effects and supportive care in gynecological radiotherapy.
๐
Today | โฐ 16:00โ17:00 CET
๐ป Online
โน๏ธMore info: https://bit.ly/4s0SXaz
๐ https://bit.ly/4slOTlN
#GynSMART #RadiationOncology
Elevated S100A9 in #HFpEF hearts drives oxidative stress and mitochondrial dysfunction; its deficiency restores #SIRT3 signaling, improves diastolic function, and reduces #hypertrophy and #fibrosis, supporting S100A9 as a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
Using integrated #scRNAseq, #Immunofluorescence, and functional validation, this study shows that the #Immunosuppressive #TumorMicroenvironment contributes to tumor aggressiveness in lymphovascular invasion-positive #PDAC.
#OpenAccess: doi.org/10.1016/j.ge...
A #disulfidptosis-based model for #HeadAndNeckCancer predicts survival and links low-risk #tumors to stronger immunity, while #multiomics highlight CXCL12โCXCR4 and identify #NQO1, with #dicoumarol boosting checkpoint therapy.
#OpenAccess: doi.org/10.1016/j.ge...
