Transcriptional reprogramming of tumor-infiltrating T cells during PD-1 blockade revealed through gene regulatory network and trajectory inference in squamous cell carcinoma https://www.biorxiv.org/content/10.1101/2025.10.15.682506v1

How do T cells rewire during PD-1 blockade?
Our new preprint combines single-cell trajectory inference + GRN modeling to reveal dynamic TFs controlling TIL fate.
🔗 www.biorxiv.org/content/10.1...
With Jordi Villà-Freixa, Lara Nonell & @adriandelomana.bsky.social

GRETA graphical abstract

We present Gene Regulatory nETwork Analsyis (GRETA), a framework to infer, compare and evaluate gene regulatory networks #GRNs. With it, we have benchmarked multimodal and unimodal GRN inference methods. Check the results here 👇
Paper: doi.org/10.1101/2024.12.20.629764
Code: github.com/saezlab/greta