Wanpen Vongpatanasin

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

figure of albuminuria reduction with finerenone

Finally, FINEONE shows Finerenone
reduces albuminuria in T1DM

www.nejm.org/doi/full/10....

@nejm.org #NephSKy

What high blood pressure does to your body Hypertension can affect your mind, heart, eyes and more, often without causing any obvious symptoms at all.

Excellent overview in The Washington Post on the systemic impact of sustained hypertension — from LVH to CKD and cognitive decline.

Kudos to Drs. @drwanpen.bsky.social , John B, and @jordybc.bsky.social for evidence base insight.

🔗 www.washingtonpost.com/wellness/202...

#Hypertension #Cardiology

New analysis led by our PhD candidate
@robynwei.bsky.social shows ⬇️ salt substitute use among US adults, Not good for BP. 🚫 real salt
@giaconajohn.bsky.social @jesslin23.bsky.social @utswim.bsky.social @jongarinn.bsky.social
ahajournals.org/doi/10.1161/...

THE EXCRETION OF INULIN, XYLOSE AND UREA BY NORMAL AND PHLORIZINIZED MAN An official website of the United States government

I was looking up the history of SGLT2 inhibitors and found this article on “phlorizinized men” and saw the first paragraph included “this evidence is direct and unequivocal in the case of the aglomerular fish” which made me double check the authors and sure enough there was
Homer W. Smith

Apple Watch for Hypertension Screening | Hypertension

Excited to share our thoughts on the Apple Watch Hypertension alert!
@jordybc.bsky.social @deanpicone.bsky.social @alta-schutte.bsky.social

Apple Watch for Hypertension Screening | Hypertension www.ahajournals.org/doi/10.1161/...

This is far from “game changer” hype they are trying to make it to be. Congrats @jordybc.bsky.social 🎉🎈

Imaging Studies of the Abdomen and Pelvis. A three-dimensional volume-rendered image of the abdominal aorta and iliac arteries (Panel A) shows no evidence of stenosis or renal-artery abnormalities. An axial CT image, obtained in the portovenous phase after the administration of intravenous contrast material (Panel B), reveals a hypoenhancing, partially exophytic mass in the left kidney (arrow). A sagittal image obtained from contrast-enhanced CT in the portovenous phase (Panel C) shows the same lesion (white arrow), with a more hypodense focus along its superior margin (black arrow). An axial T1-weighted MRI, obtained after the administration of intravenous contrast material (Panel D), shows a hypointense, hypoenhancing lesion in the left kidney (arrow). A coronal T2-weighted MRI (Panel E) shows the lesion with predominantly hypointense signal (white arrow) and a small superior cystic component (black arrow).

a young woman with hypertension and hypokalemia, which is not PA! or FMD...

www.nejm.org/doi/full/10.... in @nejm.org

Paul McCartney, Eric Clapton - While My Guitar Gently Weeps (Taken from Concert For George) YouTube video by GeorgeHarrisonVEVO

youtu.be/CrTMc2i6Lzc?...

VA

super interesting mechanistic study

effect of potassium supplement on natriuresis, with and without lisinopril
in patients with and without CKD

academic.oup.com/ndt/article-...

Bruce Springsteen - Streets Of Minneapolis (Official Audio) YouTube video by Bruce Springsteen

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.

Stay free

Our new paper @jesslin23.bsky.social showing low accuracy when eyeballing BP log and more importantly may lead to failure to start or ⬆️BP meds in HTN. Thanks 🙏all faculty&trainees for helping us @utswim.bsky.social www.ahajournals.org/doi/full/10.... @robynwei.bsky.social @giaconajohn.bsky.social

A Battle with My Blood When I was diagnosed with leukemia, my first thought was that this couldn’t be happening to me, to my family.

Hospital lore —which seems to hold up very well— is that the nicest people have the worst cancers.

God bless Tatiana Schlossberg, who while dying wrote to praise nurses and oncologists, defend scientific research, & eviscerate her cousin, RFK Jr, as he deserves

www.newyorker.com/culture/the-...

JAMA study: Spinal manipulation, self-management, and medical care for adults with acute or subacute low back pain (LBP). Results show the number of patients randomized in each therapy with findings on disability and pain.

Among patients with newly diagnosed or recent #LBP at moderate or high risk of chronicity, clinician-supported biopsychosocial self-management produced a greater proportion achieving ≥50% reduction in #disability over 12 months compared to medical care.

ja.ma/4b86EiU

Prognostic Impact of Different Definitions of White-Coat Hypertension AbstractBACKGROUND. Different definitions of white-coat hypertension (WCH) may explain its variable outcome across studies.METHODS. In an Italian study sta

Prognostic Impact of Different Definitions of White-Coat Hypertension

academic.oup.com/ajh/article/...

#OpenAccess #Free

Same to you and your family!

Happy to see our commentary with @jbrianbyrd.bsky.social suggesting that Angiotensin II should be part of the evaluation of primary hyperaldosteronism. @nu-nephrology.bsky.social @nufeinbergmed.bsky.social
www.ahajournals.org/doi/10.1161/...

Cannot decide if I enjoy jogging or post jogging street food binge in Bangkok more with Moo Ping , baked coconut mousse, and Thai beignets 😋

Increased fluid intake and blood pressure in healthy children: a randomized controlled trial. The SPA Project - Pediatric Nephrology Background High sodium intake is a key element in the development of hypertension, but strategies aimed at reducing its consumption have had limited impact at a population level. A potential alternati...

Increased fluid intake and blood pressure in healthy children: a randomized controlled trial. The SPA Project
#nephsky #nephrology
link.springer.com/article/10.1...

Jogging at Lumpini park in Bangkok. Saw the stairs with energy burn going up. Good idea to motivate people, but depressing to see that we burn < 1 kilo calorie per step !

Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet | Hypertension BACKGROUND: The rice diet (RD), a low-sodium (&lt;200 mg/d), low-protein (≈20 g/d), and low-fat (&lt;5 g/d) diet was used to treat patients with malignant hypertension beginning in the 1940s, before a...

Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet
#nephsky #nephrology
www.ahajournals.org/doi/10.1161/...

Fun elephant lab gift exchange. For some reasons, burrito blankets are popular this year! @hkkimphd.bsky.social @giaconajohn.bsky.social @k-bunsawat.bsky.social

Black-and-white photograph of Marie Curie in her Paris laboratory. She stands in a long dark dress with a high collar, carefully holding a glass round-bottom flask, surrounded by early 20th-century scientific equipment including a large glass carboy on the bench behind her. The two-time Nobel laureate is captured mid-experiment, focused and composed.

Black-and-white photograph of Irène Joliot-Curie in a white lab coat at the Radium Institute. Marie Curie’s daughter and 1935 Nobel Chemistry co-winner stands at a workbench lined with beakers, test tubes, and glassware, her expression serious and concentrated amid the tools of radioactivity research.

#OTD in 1903, Marie Curie became the first woman to win a #Nobel Prize (#Physics).

AND

#OTD in 1935, her daughter Irene Joliot-Curie won the Nobel Prize in #Chemistry for the discovery of artificial radioactivity.

They're the only mother–daughter pair to have both won Nobel Prizes. #WomenInSTEM

Also welcome new Honorary JC member @k-bunsawat.bsky.social

Good HTN journal club today by @robynwei.bsky.social discuss effects of ultraprocessed food on cardiometabolic health @giaconajohn.bsky.social @hkkimphd.bsky.social Need to eat less UPF! www.nature.com/articles/s41...

⏳In 7 days an impt discussion on #BloodPressure across Womens #Lifespan coordinated by #NIH #NHLBI

There is still time to register👉🏻
web.cvent.com/event/e7c2bdc3…

Looking fwd to presenting & learning!

Hope you will join #CardioSky #MedSky

Multiple large natural experiments have documented Shingles vaccine is linked with ~20-25% reduced risk of dementia and Alzheimer's disease. A new report today adds to that and extends the to slowing the progression of dementia @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Teens may have come up with a new way to detect, treat Lyme disease using CRISPR gene editing To compete at iGEM, a sort of science Olympics, teens at a Georgia high school set their sights on finding a better way to detect and treat Lyme disease. Their approach uses CRISPR gene editing.

Remarkable story of a Georgia high school team who used CRISPR to make a rapid diagnostic test strip for Lyme disease, speeding dx from 2 weeks to days
www.cbsnews.com/news/teens-m...

Aldo on NEJM

It’s all aldosterone on the @nejm.org right now!

www.nejm.org/browse/speci...

🙌👇👏