Gael Cristofari

Interferon Stimulatory DNA activates the DNA damage signaling through ATM and DNA-PK sensing In eukaryotic cells, DNA is normally confined in the nucleus and mitochondria and the presence of DNA in the cytoplasm is a danger signal that activates innate immune responses. Upon detection of cyto...

Happy to share the first research article of our team. We report that foreign DNA, such as ISD, activates DNA damage signaling mainly through DNA-PK.

@ircan.bsky.social @univcotedazur.bsky.social @cnrsbiologie.bsky.social @canceropolesud.bsky.social

www.jbc.org/article/S002...

Definitely ecdysone. But what are the kind of cracked lines and square overlapping with the molecule structure ?

If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️
We are looking for a postdoc to join our team at @imbavienna.bsky.social
More details 👇🏻

Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells Here, we present a workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing guide RNAs (gRNAs) to target ...

Are you interested in achieving efficient silencing of transposable elements using CRISPRi? 🧬 🧫
Go ahead and have a look at this STAR protocols where Adami et al. share all the tips & tricks they use in the Jakobsson lab.

@anitaada.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social

Key findings:

1️⃣ L1s drive large-scale rearrangements including translocations (not just insertions)

2️⃣ Frequency of these events was largely underestimated by short-reads

3️⃣ They occur EARLY, thus potentially acting as drivers

#Genomics #CancerResearch #MobileDNA @nanoporetech.com

Huge congrats to Sonia Zumalave @bernardo-rodriguez.bsky.social @mobilegenomes.bsky.social es.bsky.social Jose Tubio & team!

Happy to have (modestly) contributed!
@inserm.fr @insermpacacorse.bsky.social
@cnrsbiologie.bsky.social @univcotedazur.bsky.social @ircan.bsky.social

Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

Today in
@science.org:
We are pleased to present our last work entitled:
"Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis"
by Zumalave et al.
www.science.org/doi/10.1126/...

😅

Nuclear speckles enable processing of RNA from GC-rich isochores Nuclear speckles are key subnuclear structures that regulate gene expression in GC-rich regions. This work shows that the evolution and expansion of core speckle proteins were crucial for the increase...

The function of nuclear speckles is revealed! This is an incredibly important paper with absolutely beautiful data! Wow! www.cell.com/cell/fulltex...

Define ‘mid-career PI’. Asking for a friend.

A reference-free pipeline for detecting shared transposable elements from pan-genomes to retrace their dynamics in a species - Genome Biology Background The role of transposable elements (TEs) in host adaptation has gained interest in recent years. Individuals of the same species undergo independent TE insertions, providing genetic variabil...

🚨📢📄 Article in press in Genome Biology doi.org/10.1186/s130...
We introduce panREPET, a reference-free pipeline to detect shared transposable element (TE) insertions across pangenomes and retrace their evolutionary dynamics #TEsky 🧵👇

Thanks Josefa !

Thank you and welcome to France !

Thanks !

Plongez dans les projets de recherche azuréens lauréats de l'@agencerecherche.bsky.social au travers de vidéos vulgarisées au format "tableau blanc" à retrouver ici 👇

🎥 www.cote-azur.cnrs.fr/fr/cnrsinfo/...

@univcotedazur.bsky.social @insermpacacorse.bsky.social @cnrsbiologie.bsky.social

Happy new year and 3 more days to apply for Computational biology post doc position in my lab #Paris #transpoosns @inem-necker.bsky.social @institutimagine.bsky.social

🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.

It was fun to write this preview with Larisa Okorokova. Congrats to @jakobssonlab.bsky.social and all coauthors for this nice piece of work !

Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.

➡️ www.cell.com/cell-genomic...

From the archives: When should you stop doing science and start writing a paper? Start writing as soon as you have at least one result.

open.substack.com/pub/clauswil...

Pls. share widely

Calling all transposon fans & lovers of genetic innovation

MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025

→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)

submit abstract by July 29

White Board #1 : L'histoire des gènes sauteurs YouTube video by Université Côte d'Azur

Connaissez-vous l'histoire des gènes sauteurs ?🧬
Dans cette vidéo, Gaël Cristofari, chercheur ( #UniCA, @cnrs.fr, @inserm.fr) explique de manière claire et illustrée comment ces gènes se déplacent et quel rôle essentiel ils jouent dans notre génétique.
➡️https://youtu.be/twtOhB-TPJk?feature=shared

Aedes albopictus (asian tiger mosquito)

🦟 Bioinformatics Research Scientist position open in my lab in Nice (FR) to study Aedes mosquito retrotransposons & their interactions with arboviruses collab w/ @salehlabparis.bsky.social & @lambrechtslab.bsky.social
Apply: euraxess.ec.europa.eu/jobs/359830
Please boost! #ArboRetro #Bioinformatics

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Thrilled to receive @anrs-mie.bsky.social grant with @lambrechtslab.bsky.social & @retrogenomics.bsky.social! Making mosquitoes intolerant to arboviruses. Thanks @pasteur.fr, @inserm.fr & @cnrs.fr for support. Exciting times for #ARBORETRO project! Stay tunned.

Please repost
@cedricfeschotte.bsky.social @aktast.bsky.social @brancolab.bsky.social @emiliebrasset.bsky.social @jakobssonlab.bsky.social @macromomo.bsky.social

CSH-Asia "The Repetitive and Mobile Genome" meeting announcement poster

Don't miss the first edition of the CSH-Asia meeting on "The Repetitive and Mobile Genome" taking place in Suzhou, China.
📅 Abstract submission deadline extended: Feb 21, 2025
👉 www.csh-asia.org?content/2544
#transposon #mobileDNA #TEsky

📣 #EMBOMobileGenome is open for registrations!

Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍

📜 Submit abstract by 29 July!
👉🏼 https://s.embl.org/mge25-01-bl

Very proud of this work led by @sophielanciano.bsky.social
🖥️🧬🧪 #TEsky

I'm so excited to announce that our story on LINE-1 DNA methylation has been published in @CellGenomics 🥳🥳

With @retrogenomics.bsky.social @aurelien-doucet.bsky.social and all other authors.

Enjoy the reading!

www.cell.com/cell-genomic...

See original thread below.