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Pritish Patil

@iampritishpatil

Neuroscientist (in training). Grad student with Ofer Yizhar and Misha Tsodyks at Weizmann Insititute of Science. Optogenetics, dendritic computation and neural circuits

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16.11.2024
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Latest posts by Pritish Patil @iampritishpatil

I taught an octopus piano (It took 6 months)
I taught an octopus piano (It took 6 months) YouTube video by Mattias Krantz

Youtubers never fail to surprise me! He tried to teach an octopus to play piano!

www.youtube.com/watch?v=PcWn...

14.02.2026 07:38 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

So "is representation drift real" is the "is LTP presynaptic or postsynaptic" of 2020s.

13.02.2026 18:46 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The names random and fixed effects are entirely unhelpful, and confuse the model for reality.

29.01.2026 21:41 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Attention-like regulation of theta sweeps in the brain's spatial navigation circuit Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion β€” without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

The hippocampal map has its own attentional control signal!
Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See πŸ“Ή in post 4/6 and preprint here πŸ‘‰
www.biorxiv.org/content/10.6...
🧡(1/6)

28.01.2026 10:03 πŸ‘ 183 πŸ” 62 πŸ’¬ 4 πŸ“Œ 10
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πŸ“† Mark your calendars: #OptoGRC2026 is headed back to Tuscany, May 10-15, 2026!

We look forward to reuniting with our amazing community for a week of great science, thoughtful discussions & shared time with colleagues.

More details coming soonπŸ‘‡πŸ½
tinyurl.com/esvrabsu

23.05.2025 20:05 πŸ‘ 51 πŸ” 17 πŸ’¬ 0 πŸ“Œ 0
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I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @science.org, where we recorded neurons in bats flying outdoors on an island.

doi.org/10.1126/sci...

With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others

16.10.2025 18:04 πŸ‘ 118 πŸ” 37 πŸ’¬ 6 πŸ“Œ 9
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In 2016, the first Opto GRC was created to bring together scientists pushing the boundaries of optogenetics research 🧠🌟

Join us to celebrate 10 incredible years of collaboration and discoveryβ€”applications for #OptoGRC2026 are now open!

Apply now: www.grc.org/optogenetic-...

10.10.2025 19:19 πŸ‘ 18 πŸ” 10 πŸ’¬ 0 πŸ“Œ 0
Preview
High-entropy nanomaterials by candlelight - Nature Chemistry High-entropy materials offer an exciting realm of possibilities for material discovery and application; however, their nanoscale synthesis is limited by the need for specialized equipment. Now, a simple synthetic strategy employing wax candles enables production of these compositionally complex nanomaterials.

Sometimes the lamppost you’re looking under is a candle β€” and it still gets you Nature Chemistry.

doi.org/10.1038/s415...

26.09.2025 10:00 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).

12.09.2025 15:21 πŸ‘ 106 πŸ” 34 πŸ’¬ 4 πŸ“Œ 1

Loved reading this today!

05.07.2025 09:31 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Can you do a PhD in self-supervised learning without an academic advisor?

06.05.2025 15:29 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

It is true, the world can truly be explained by physics.

05.04.2025 09:48 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

How tariffs are calculated in 2025 is detailed balance.

05.04.2025 09:48 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

The trade in the world follows balance. The total amount of trade by a country with the rest of the world over long terms is balance.

05.04.2025 09:48 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Do you have trouble understanding the difference between balance and detailed balance in statistical physics? Here's a real world example:

05.04.2025 09:48 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Hollywood loves making movies about making movies.

AI folks? We make AIs that help describe other AIs. Or help you talk to an AI through an API.

29.03.2025 20:45 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Sorry to hear what you've been going through Mark, it's tough times.

Glad to hear it's on the positive side of things now. Hope to keep seeing the amazing science coming from your lab.

10.03.2025 04:51 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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How does the brain work in natural scenarios, in multi-animal societies of wild animals? 🧠 πŸ§ͺ πŸ¦‡

doi.org/10.1126/scie...

(1/n)

30.01.2025 19:20 πŸ‘ 69 πŸ” 31 πŸ’¬ 7 πŸ“Œ 6
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Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!

14.01.2025 04:58 πŸ‘ 59 πŸ” 39 πŸ’¬ 2 πŸ“Œ 5

fmov d29, x0
fmul s31, s29, s30
fmul s31, s31, s29
fmov s0, 1.5e+0
fsub s31, s0, s31
fmul s31, s31, s29
fmul s30, s31, s30
fmul s30, s30, s31
fsub s0, s0, s30
fmul s0, s0, s31
add sp, sp, 16
ret

11.01.2025 16:12 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Func(float):
sub sp, sp, #16
fmov s30, 5.0e-1
fmul s30, s0, s30
str s0, [sp, 12]
ldr x0, [sp, 12]
mov x1, 23007
movk x1, 0x5f37, lsl 16
sub x0, x1, x0, asr 1
lsr w0, w0, 0

11.01.2025 16:12 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Can a neuroscientist understand a microcontroller?
OR
Do we have a brain decompiler?
OR
Seeing the following instructions (arm64) being executed, can you figure out the algorithm being implemented? Input a float, output a float. How can you try to understand it?

#Marr3Levels

11.01.2025 16:12 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Glad you liked it! I'm still 3/4th in. Excited for how it ends :)

29.12.2024 13:17 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

If you see someone using the variable name "ii" as the iterator in a for loop, chances are, their first programing language was MATLAB. I find this amusing.

24.12.2024 19:10 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I'm reading "How to Become the Dark Lord and Die Trying" right now, and it's funny and far from depressing.

15.12.2024 11:49 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Congratulations!! πŸŽ‰πŸŽ‰

14.12.2024 17:27 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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High-speed 3D random access two-photon imaging at β‰₯ 300 kHz – with SPARCLS: opg.optica.org/optica/fullt...

By the outstanding @carolineberlage.bsky.social and team, including @urslucasboehm.bsky.social, @andrewplested.bsky.social et al.

10.12.2024 20:17 πŸ‘ 44 πŸ” 11 πŸ’¬ 1 πŸ“Œ 5

Many people have asked me what's the deal with "SIO" in our Addgene vectors (www.addgene.org/Ofer_Yizhar/) - we use these in most of our Cre-dependent AAVs - so here's a brief explanation of how it works.

28.11.2024 18:12 πŸ‘ 58 πŸ” 17 πŸ’¬ 4 πŸ“Œ 1

It should all be neurovoxels really.

20.11.2024 05:33 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

What do sonogenetics and magnetogenetics look like?

19.11.2024 15:23 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0