Many thanks to Gilad Levy who led the entire study and the amazing team who made this possible: Asaf Marco, Inna Slutsky, Elior Peles, @myelincentric.bsky.social Hauke Werner, Yaniv Assaf, Noam Shomron

#myelin, #oligodendrocytes, #whitematter, #multiplesclerosis, #gtf2i

This discovery could inspire new treatments for many neurological conditions affected by myelination dysfunction.

Here’s what it looks like 👇

Gtf2i-encoded transcription factor Tfii-i regulates myelination via Sox10 and Mbp regulatory elements - Nature Communications The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.

🚀 Our new paper is out in Nature Communications!

We uncovered a mechanistic switch to boost myelination: deleting Gtf2i in myelinating glia enhances Sox10/Mbp activity → thicker myelin, faster conduction, improved motor coordination.

Open access link:

www.nature.com/articles/s41...

Transcriptional profiles of mouse oligodendrocyte precursor cells across the lifespan - Nature Aging A single-cell transcriptomic profile of oligodendrocyte precursor cells in the brain across the mouse lifespan reveals aging-associated changes that contribute to the decline of oligodendrogenesis in ...

Another great work from the Bergles group. Transcriptional profiles of mouse oligodendrocyte precursor cells across the lifespan | Nature Aging
www.nature.com/articles/s43...

Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior Early life events shape neuronal networks, and prime juvenile and adult behavior. Severely aversive, early experiences can interfere with brain development and enhance the risk for the onset of psychi...

Cool work on the effects of OPC specific deletion of glucocorticoid receptors!

Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior
www.biorxiv.org/content/10.1...

So well deserved! Congrats Wendy! @droligo.bsky.social

If you submit your grants last minute, you're in good company. For the 2005 NIH Pioneer grant, half of the applications were submitted in the last two days. The red bars indicate the awardees. One awardee submitted 8 minutes before the deadline.
bsky.app/profile/jere... @jeremymberg.bsky.social

Thanks Ethan for organizing this. Makes the transfer easier. Would love to be added, please. Thanks! @ethanhugheslab.bsky.social