Uropathogenic E. coli uses a novel two-gene system, DanRI, to outsmart neutrophils by blocking NETs and ROS. Induced by host nucleosomes, DanRI boosts bacterial survival & persistence. A new twist in immune evasion!
βοΈ @doracerina.bsky.social & coll.
π shorturl.at/cAj05
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Huge thanks to everyone on the team who made this possible!
In our study, we discovered a previously unknown two-gene system in UPEC that we named DanRI (Defense against neutrophil Regulator and Inhibitor). This system is turned on by NETs and helps the bacteria block neutrophil attacks. Without DanRI, UPEC struggles to survive and persist during infections.
The main culprit behind urinary tract infections is a strain of E. coli known as UPEC. To survive in the body, UPEC has to evade our immune system, especially neutrophils, a type of immune cell that traps and kills bacteria using web-like structures called NETs.
The main culprit behind urinary tract infections is a strain of E. coli known as UPEC. To survive in the body, UPEC has to evade our immune system, especially neutrophils, a type of immune cell that traps and kills bacteria using web-like structures called NETs. In our study, we discovered a previously unknown two-gene system in UPEC that we named DanRI (Defense against neutrophil Regulator and Inhibitor). This system is turned on by NETs and helps the bacteria block neutrophil attacks. Without DanRI, UPEC struggles to survive and persist during infections.
We're excited to share our new preprint on bioRxiv! β¨
You can view it here: www.biorxiv.org/content/10.1...
See below for more information π
π¨ Paper alert! Happy to share the new publication by the Zychlinsky Lab (@mpiib.bsky.social) and Torres Lab (@torreslab.bsky.social) with the succinct but effective title "Histone H1 kills MRSA".
You can find the paper here: www.cell.com/cell-reports...
