Great work from post-doctoral fellow @joanzone.bsky.social:
New preprint on identifying active structures of protein kinases -- capable of binding ATP, Mg ions & especially substrates -- +modeling all 437 human catalytic protein kinase domains in their active conformation.
doi.org/10.64898/202...
Noice!
How to post about Shoah, but don’t upset your voter base!
The BBC coverage is absolutely terrible.
It leads on "sharply contested narratives"
It has a dramatic skew to the US government
It has posted the video but has failed to report on what it shows: it shows the US govt account is untrue
A classic quod licet bovi, non licet Iovi 😂 (sorry about this, I’ll see myself out)
Being a Nazi and running a company that does child pornography is not a normal level of “a bad person”. Have some honor.
First of all, it’s a huge disgrace he was elected in the first place. Second of all, drawing comparisons to Newton? This is all very embarrassing.
Time to stop writing articles about the "security" or "economic" reasons to capture Greenland, they are irrelevant
Their numbers are cherrypicked. But I have seen first hand. Impressive, really.
Merry Christmas, genetic interaction nerds:
www.biorxiv.org/content/10.6...
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Exciting stuff!
Probably explains why science is better when you do it do fun than when you do it to win.
Figure showing that Src kinase and membrane order contribute to stiffness-dependent EGFR activation.
Aneesa Shaikh, Maddy Parsons and colleagues investigate ligand- and integrin-independent mechano-sensitive EGFR activation in lung cancer cells.
journals.biologists.com/jcs/article/...
Darwin's regrets:
"If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"
The fact that 12% of federal judges are Black shows the corruption of DEI. The fact that 67% of Supreme Court Justices belong to a small legal cult called the Federalist Society shows the power of meritocracy.
Introduce yourself with 5 concerts you’ve seen:
Radiohead
The Rolling Stones
Jack White
Bob Dylan
Hélène Grimaud
New paper “Proteome-wide model for human disease genetics” is now live at Nature Genetics: rdcu.be/eRu7K
popEVE (pop.evemodel.org) finds the needles in the haystacks of human genetic variation:
This is bound to be a great place!
This.
Reading that text I was convinced that this lady is indeed no intellect, just emotions. No facts or math, just gossip. And then she just concluded all women must be like that.
May her memory be a blessing.
The amount of AI generated art in slides at this conference, primarily used by older scientists, is killing me. Scientists please. Don’t use these ai platforms to make your figures or slides. They look bad and I have yet to see them meaningfully improve the message of talks.
Oh, bloody brilliant! Guess what I’m replying next time I don’t care to review something!
Nice work. Thanks for a fantastic skeetorial, always appreciated
The @nytimes.com decided last year what the story was; Trump II was the righteous punishment visited upon their interns and junior staffers and grandchildren for being so annoying about MeToo and BLM, and once they understood that and repented, they could have democracy back.
I wrote a blog post about the future of structural bioinformatics.
Where to go after AlphaFold? How do we avoid the field becoming a load of half-baked LLMs?
Let me know what you think.
jgreener64.github.io/posts/struct...
I’ll let you know if we see anything interesting!
One thing is for sure, fun with RAF never ends! (10/10)
