neuromapr 0.2.1 has been accepted and published on CRAN!
Very excited to get this out to users in the simplest way possible, and hope the #rstats #neuroimaging community finds it useful!
lcbc-uio.github.io/neuromapr/
New paper out!
We systematically compared how ATN biomarker changes track cognitive decline in AD:
Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not.
Ptau217 = cost-effective proxy for monitoring cognitive changes in AD
doi.org/10.1002/alz....
I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology!
Here's a short thread about the main findings of the paper...
🚨Postdoc position open at @BarcelonaBeta🚨
We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠
Fully funded position!!!
More details: www.imim.cat/media/upload...
Please share!
#Alzheimer's #ENDALZ
I have just dropped a new version of my academicdb project, which helps prolific researchers generate a CV automatically. Now with a web interface! If you are interested, please try it out and let me know what you think - it takes a bit of setup work but then runs easily using Docker.
Out now in Brain: Our new study shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
academic.oup.com/brain/articl...
🔥Recent advances in #neuroimaging of #Alzheimers disease 🧠✨
dx.doi.org/10.1002/alz....
➡️ Valuable resource for both researchers & clinicians!
➡️ ATNIV biomarkers, staging, connectomics & more
➡️ Plus: how are sex & country represented in first/last authorship?
@istaart.bsky.social Neuroimaging PIA
Working Link:
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to co-senior author @matthiasbrendel.bsky.social as well as Günter Höglinger, Johannes Gnörich @sebroemer.bsky.social, Carla Palleis, Anna Dewenter, Anna Steward, Davina Biel, @johanneslevin.bsky.social and many others
The study was motivated by cerebellar 4R tau in PSP potentially confounding conventional cerebellar tau-PET reference regions. Using a data driven approach, we identified temporo-orbital white matter as a suitable reference that may support the biomarker workup in 4R tauopathies
Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
doi.org/10.1007/s002...
Many thanks to co-senior author Günter Höglinger, @matthiasbrendel.bsky.social, @johanneslevin.bsky.social, @sebroemer.bsky.social, Johannes Gnörich, @mauramalpetti.bsky.social and many others!
Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds....
Alzheimer's disease drug development pipeline: 2025 - Cummings - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
A chart showing cancelled NIH grants
“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ
Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.
Apply here👇
shorturl.at/LpCAq
Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory.
www.cell.com/cell/fulltex...
Super excited to announce a PhD position on polypathology in the medial temporal lobe at the Paris Brain Institute together with @nvillain-alz.bsky.social and @robindeflores.bsky.social!
offres.institutducerveau-icm.org/fr/jobs/1935...
Please repost!
When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years.
www.sciencedirect.com/science/arti...
Just out in JAMA Neurol blood biomarkers are powerful—but without cognitive phenotyping, we risk more noise than signal.
Plasma p-tau217 needs clinical context or we’ll end up in a false-positive factory!
Clinico-biological AD is a reality!
👉🏻 jamanetwork.com/journals/jam...
bsky.app/profile/vinc...
The Fredericks Lab! - with deliberately poor photoshopping of lab members who couldn't be there that day.
We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral...
Please share with your circles!
Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich:
Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.
doi.org/10.1007/s002...
Many thanks to @sebroemer.bsky.social, @matthiasbrendel.bsky.social, @johanneslevin.bsky.social, Günter Höglinger and many more
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s130...
Great working with Sujala Ghatamaneni, Val Lowe, and colleagues on this high resolution autoradiography study of MK-6240 and flortaucipir🧠🖥️
link.springer.com/article/10.1...
@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social
The research group of Prof. Dr. Dominik Paquet (https://www.isd-research.de/paquetlab) is looking for a Postdoc. Our research involves the development of human brain tissue models to study the molecular mechanisms of Alzheimer's disease, Frontotemporal dementia, stroke and other related brain diseases and to develop therapeutic approaches. We use state-of-the-art molecular and cell biological methods, such as induced pluripotent stem cells (iPSCs), advanced molecular biology techniques, CRISPR/Cas9 genome editing, brain tissue engineering, scRNAseq, proteomics etc. We offer a highly international, versatile, extremely well equipped and productive work environment. We have received funding by an international research organization for a very interdisciplinary and collaborative project to develop a human iPSC model of the blood brain barrier and apply it to study neurovascular diseases, with a focus on Small vessel disease (SVD). The project will focus on CRISPR genome engineering of SVD-relevant mutations, differentiation of iPSCs into neurovascular cells, microfluidic 3D vascular tissue engineering, and identifying disease-relevant alterations by microscopy and omics techniques. It will be embedded in the highly collaborative and stimulating environment of the PaquetLab, ISD, SyNergy Cluster of Excellence, and our international collaboration network. We are looking for a highly motivated individual with the following skills: -extensive international scientific working experience in vascular biology or a closely related research field (required) -experience in molecular biology, biochemistry and/or omics techniques; cell culture experience is a plus -excellent English skills in speaking, writing about and presenting scientific data -interest in working in collaborative network of friendly scientists around the world A start date soon in 2025 is desired. Join us! dominik.paquet@med.uni-muenchen.de www.isd-research.de/paquetlab www.brenda-leducq.de
Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
www2.daad.de/deutschland/...
Zelensky is a wartime leader watching his people suffer and die under Russian attacks every day. To be lectured and lied to by Trump and Vance, as they defend the war criminal dictator committing these atrocities, is unimaginable agony. An everlasting shame for America.
