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Bose Lab Sheffield

@bose-lab

Working on mechanistic enhancer biology at the University of Sheffield, UK. Part of Sheffield Nucleic Acids Institute and Centre for Single Molecule Biology See also @danbose.bsky.social

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15.11.2024
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Latest posts by Bose Lab Sheffield @bose-lab

Exciting new packages!! Very cool ❄️ to see the new microscope (JEMma) added to the cryoEM facility to keep @AvaArctica company @sheffielduni.bsky.social @mcb-sheffield.bsky.social! (Ok, it does look a little bit like a washing machine!) lookout for more details soon!

29.01.2025 15:21 👍 1 🔁 1 💬 0 📌 0
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The conformational space of RNase P RNA in solution - Nature Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution.

Amazing #RNA structural ensembles! Really highlights how important #singlemolecule approaches are for finding mechanism in sustems and models that move! www.nature.com/articles/s41...

20.12.2024 06:28 👍 10 🔁 2 💬 0 📌 0
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Cooperation between Intrinsically Disordered Regions regulates CBP condensate behaviour Creb binding protein (CBP) and EP300 (p300) are transcription coactivators that bind at cis -regulatory elements and regulate gene expression in multicellular organisms. They contain large intrinsical...

Posting this awesome work from the summer led by Katie in our team- currently undergoing some exciting new upgrades :) www.biorxiv.org/content/10.1...

08.11.2024 07:48 👍 9 🔁 2 💬 0 📌 0

With some help from @raduzabet.bsky.social, I've created a starter pack of researchers working on #Epigenetics, Chromatin and Gene Regulation who are active on here:
go.bsky.app/TKp9YAn
I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.

01.11.2024 08:40 👍 117 🔁 69 💬 61 📌 1

Fantastic, well articulated review reconciling how regulatory complexes at the molecular level function in the context of transcriptional condensates.

13.11.2024 20:46 👍 1 🔁 1 💬 0 📌 0
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Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

15.11.2024 17:55 👍 72 🔁 80 💬 0 📌 4
https://www.rug.nl/about-ug/work-with-us/job-opportunities/?details=00347-02S000B06P

Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705

15.11.2024 21:13 👍 35 🔁 49 💬 0 📌 2

Bringing the lab account over too!! Check us out at @bose-lab.bsky.social 🧬🥼🧪⚗️🔬🪴

15.11.2024 20:16 👍 6 🔁 2 💬 0 📌 0